Ovarian germ cell tumor risk factors: Difference between revisions
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[[Gonadal dysgeneisis]] and androgen insensitivity syndrome are known risk factors for the development of [[ovarian]] [[germ cell]] [[tumors]]. | [[Gonadal dysgeneisis]] and androgen insensitivity syndrome are known risk factors for the development of [[ovarian]] [[germ cell]] [[tumors]]. | ||
==Risk Factors== | ==Risk Factors== | ||
[[Ovarian]] [[germ cell]] [[tumors]] tend to affect individuals with [[gonadal dysgenesis]] at a greater extent.<ref name="PleskacovaHersmus2010">{{cite journal|last1=Pleskacova|first1=J.|last2=Hersmus|first2=R.|last3=Oosterhuis|first3=J.W.|last4=Setyawati|first4=B.A.|last5=Faradz|first5=S.M.|last6=Cools|first6=M.|last7=Wolffenbuttel|first7=K.P.|last8=Lebl|first8=J.|last9=Drop|first9=S.L.|last10=Looijenga|first10=L.H.|title=Tumor Risk in Disorders of Sex Development|journal=Sexual Development|volume=4|issue=4-5|year=2010|pages=259–269|issn=1661-5433|doi=10.1159/000314536}}</ref> | *[[Ovarian]] [[germ cell]] [[tumors]] tend to affect individuals with [[gonadal dysgenesis]] at a greater extent.<ref name="PleskacovaHersmus2010">{{cite journal|last1=Pleskacova|first1=J.|last2=Hersmus|first2=R.|last3=Oosterhuis|first3=J.W.|last4=Setyawati|first4=B.A.|last5=Faradz|first5=S.M.|last6=Cools|first6=M.|last7=Wolffenbuttel|first7=K.P.|last8=Lebl|first8=J.|last9=Drop|first9=S.L.|last10=Looijenga|first10=L.H.|title=Tumor Risk in Disorders of Sex Development|journal=Sexual Development|volume=4|issue=4-5|year=2010|pages=259–269|issn=1661-5433|doi=10.1159/000314536}}</ref> | ||
*Maternal hormonal factors are another things associated with the increased rissk of the development of ovarian germ cell tumors in daughters. These factors include:<ref name="SharpeSkakkebaek2008">{{cite journal|last1=Sharpe|first1=Richard M.|last2=Skakkebaek|first2=Niels E.|title=Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects|journal=Fertility and Sterility|volume=89|issue=2|year=2008|pages=e33–e38|issn=00150282|doi=10.1016/j.fertnstert.2007.12.026}}</ref><ref name="SkakkebækRajpert-De Meyts2001">{{cite journal|last1=Skakkebæk|first1=N.E.|last2=Rajpert-De Meyts|first2=E.|last3=Main|first3=K.M.|title=Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects: Opinion|journal=Human Reproduction|volume=16|issue=5|year=2001|pages=972–978|issn=1460-2350|doi=10.1093/humrep/16.5.972}}</ref><ref name="pmid3390378">{{cite journal |vauthors=Walker AH, Ross RK, Haile RW, Henderson BE |title=Hormonal factors and risk of ovarian germ cell cancer in young women |journal=Br. J. Cancer |volume=57 |issue=4 |pages=418–22 |date=April 1988 |pmid=3390378 |pmc=2246577 |doi= |url=}}</ref> | |||
**Maternal use of exogenous hormones (ie, supportive hormones or oral contraceptives) | |||
**Maternal high body mass index | |||
*Other reproductive factors also has been observed to be associated with the development of these tumors such as: | |||
**Parity | |||
**Oral contraceptive use | |||
**Age at first and last births | |||
===Mature teratoma=== | ===Mature teratoma=== | ||
*Common risk factors in the malignant transformation of mature teratoma include: | *Common risk factors in the malignant transformation of mature teratoma include: | ||
| Line 13: | Line 20: | ||
===Dysgerminoma=== | ===Dysgerminoma=== | ||
*Common risk factors in the development of dysgerminoma are [[gonadal dysgenesis]], [[androgen insensitivity syndrome]] and [[gonadoblastoma]].<ref name= wqd>{{cite book | last = Kliegman | first = Robert | title = Nelson textbook of pediatrics | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2011 | isbn = 978-1-4377-0755-7 }}</ref> | *Common risk factors in the development of dysgerminoma are [[gonadal dysgenesis]], [[androgen insensitivity syndrome]] and [[gonadoblastoma]].<ref name= wqd>{{cite book | last = Kliegman | first = Robert | title = Nelson textbook of pediatrics | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2011 | isbn = 978-1-4377-0755-7 }}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Monalisa Dmello, M.B,B.S., M.D. [3]
Overview
Gonadal dysgeneisis and androgen insensitivity syndrome are known risk factors for the development of ovarian germ cell tumors.
Risk Factors
- Ovarian germ cell tumors tend to affect individuals with gonadal dysgenesis at a greater extent.[1]
- Maternal hormonal factors are another things associated with the increased rissk of the development of ovarian germ cell tumors in daughters. These factors include:[2][3][4]
- Maternal use of exogenous hormones (ie, supportive hormones or oral contraceptives)
- Maternal high body mass index
- Other reproductive factors also has been observed to be associated with the development of these tumors such as:
- Parity
- Oral contraceptive use
- Age at first and last births
Mature teratoma
- Common risk factors in the malignant transformation of mature teratoma include:
Dysgerminoma
- Common risk factors in the development of dysgerminoma are gonadal dysgenesis, androgen insensitivity syndrome and gonadoblastoma.[7]
References
- ↑ Pleskacova, J.; Hersmus, R.; Oosterhuis, J.W.; Setyawati, B.A.; Faradz, S.M.; Cools, M.; Wolffenbuttel, K.P.; Lebl, J.; Drop, S.L.; Looijenga, L.H. (2010). "Tumor Risk in Disorders of Sex Development". Sexual Development. 4 (4–5): 259–269. doi:10.1159/000314536. ISSN 1661-5433.
- ↑ Sharpe, Richard M.; Skakkebaek, Niels E. (2008). "Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects". Fertility and Sterility. 89 (2): e33–e38. doi:10.1016/j.fertnstert.2007.12.026. ISSN 0015-0282.
- ↑ Skakkebæk, N.E.; Rajpert-De Meyts, E.; Main, K.M. (2001). "Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects: Opinion". Human Reproduction. 16 (5): 972–978. doi:10.1093/humrep/16.5.972. ISSN 1460-2350.
- ↑ Walker AH, Ross RK, Haile RW, Henderson BE (April 1988). "Hormonal factors and risk of ovarian germ cell cancer in young women". Br. J. Cancer. 57 (4): 418–22. PMC 2246577. PMID 3390378.
- ↑ Hackethal A, Brueggmann D, Bohlmann MK, Franke FE, Tinneberg HR, Münstedt K (December 2008). "Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data". Lancet Oncol. 9 (12): 1173–80. doi:10.1016/S1470-2045(08)70306-1. PMID 19038764.
- ↑ Park, Jeong-Yeol; Kim, Dae-Yeon; Kim, Jong-Hyeok; Kim, Yong-Man; Kim, Young-Tak; Nam, Joo-Hyun (2008). "Malignant transformation of mature cystic teratoma of the ovary: Experience at a single institution". European Journal of Obstetrics & Gynecology and Reproductive Biology. 141 (2): 173–178. doi:10.1016/j.ejogrb.2008.07.032. ISSN 0301-2115.
- ↑ Kliegman, Robert (2011). Nelson textbook of pediatrics. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4377-0755-7.