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==Overview== | ==Overview== | ||
The cause of most parathyroid adenomas is unknown. However, about 10% are said to be [[hereditary]]. It can be the result of multiple genetic mutations in genes such as the calcium-sensing receptor gene, HRPT2 gene (CDC73 gene), Cyclin D1 gene (CCND1)/PRAD1 gene, MEN1 gene, and RET gene. | |||
The | |||
==Causes== | ==Causes== | ||
Solitary parathyroid adenoma is the leading cause of [[primary hyperparathyroidism]] in 80% to 85% of cases.<ref name="pmid26163537">{{cite journal |vauthors=Duan K, Gomez Hernandez K, Mete O |title=Clinicopathological correlates of hyperparathyroidism |journal=J. Clin. Pathol. |volume=68 |issue=10 |pages=771–87 |date=October 2015 |pmid=26163537 |doi=10.1136/jclinpath-2015-203186 |url=}}</ref> | |||
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===Genetic Causes=== | ===Genetic Causes=== | ||
* | *Parathyroid adenoma can be caused by a mutation of the following genes. | ||
:*Calcium-sensing receptor gene | |||
:*HRPT2 gene (CDC73 gene) | |||
:*[[Cyclin D1 gene]] (CCND1)/PRAD1 gene | |||
:*[[MEN1 gene]] | |||
:*[[RET gene]] | |||
Revision as of 00:11, 25 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
The cause of most parathyroid adenomas is unknown. However, about 10% are said to be hereditary. It can be the result of multiple genetic mutations in genes such as the calcium-sensing receptor gene, HRPT2 gene (CDC73 gene), Cyclin D1 gene (CCND1)/PRAD1 gene, MEN1 gene, and RET gene.
Causes
Solitary parathyroid adenoma is the leading cause of primary hyperparathyroidism in 80% to 85% of cases.[1]
Genetic Causes
- Parathyroid adenoma can be caused by a mutation of the following genes.
- Calcium-sensing receptor gene
- HRPT2 gene (CDC73 gene)
- Cyclin D1 gene (CCND1)/PRAD1 gene
- MEN1 gene
- RET gene
- ↑ Duan K, Gomez Hernandez K, Mete O (October 2015). "Clinicopathological correlates of hyperparathyroidism". J. Clin. Pathol. 68 (10): 771–87. doi:10.1136/jclinpath-2015-203186. PMID 26163537.