Parathyroid adenoma causes: Difference between revisions
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==Causes== | ==Causes== | ||
Solitary parathyroid adenoma is the leading cause of [[primary hyperparathyroidism]] in 80% to 85% of cases.<ref name="pmid26163537">{{cite journal |vauthors=Duan K, Gomez Hernandez K, Mete O |title=Clinicopathological correlates of hyperparathyroidism |journal=J. Clin. Pathol. |volume=68 |issue=10 |pages=771–87 |date=October 2015 |pmid=26163537 |doi=10.1136/jclinpath-2015-203186 |url=}}</ref> | Solitary parathyroid adenoma is the leading cause of [[primary hyperparathyroidism]] in 80% to 85% of cases. However, parathyroid adenoma is idiopathic in approximately 90% of the individuals.<ref name="pmid26163537">{{cite journal |vauthors=Duan K, Gomez Hernandez K, Mete O |title=Clinicopathological correlates of hyperparathyroidism |journal=J. Clin. Pathol. |volume=68 |issue=10 |pages=771–87 |date=October 2015 |pmid=26163537 |doi=10.1136/jclinpath-2015-203186 |url=}}</ref> | ||
===Genetic Causes=== | ===Genetic Causes=== | ||
Revision as of 12:22, 26 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
The cause of most parathyroid adenomas is unknown. However, about 10% are said to be hereditary. It can be the result of multiple genetic mutations in genes such as the calcium-sensing receptor gene, HRPT2 gene (CDC73 gene), Cyclin D1 gene (CCND1)/PRAD1 gene, MEN1 gene, and RET gene.
Causes
Solitary parathyroid adenoma is the leading cause of primary hyperparathyroidism in 80% to 85% of cases. However, parathyroid adenoma is idiopathic in approximately 90% of the individuals.[1]
Genetic Causes
- Parathyroid adenoma can be caused by a mutation of the following genes.
- Calcium-sensing receptor gene
- HRPT2 gene (CDC73 gene)
- Cyclin D1 gene (CCND1)/PRAD1 gene
- MEN1 gene
- RET gene
References
- ↑ Duan K, Gomez Hernandez K, Mete O (October 2015). "Clinicopathological correlates of hyperparathyroidism". J. Clin. Pathol. 68 (10): 771–87. doi:10.1136/jclinpath-2015-203186. PMID 26163537.