Neurofibroma classification: Difference between revisions
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* Most common | * Most common | ||
* | * Occurs as lumps or bumps on skin | ||
* Painless | * Painless | ||
* Slowly growing | * Slowly growing | ||
* < 5cm diameter | * < 5cm diameter | ||
* Starts in teenage years or young adults and rarely starts in childhood | |||
* Increase in size and number over the years | |||
* Clearly defined borders hence, can be removed if necessary | |||
* Number of skin tumors in each patient varies tremendously | |||
* Mostly solitary and sporadic, not associated with NF1 | * Mostly solitary and sporadic, not associated with NF1 | ||
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* Uncommon | * Uncommon | ||
* | * Feels soft and squishy | ||
* | * Usually involves scalp or trunk (often protruding out, like a “love handle”) | ||
* Runs through the full [[skin]] thickness | * Ill defined margins, can't tell where tumor stops | ||
* | * Runs through the full [[skin]] thickness (from the surface all the way down to the base of the skin (subcutaneous fascia/fat) | ||
* | * Doesn't go deeper than fascia | ||
* Usually seen in early childhood and young adults | |||
* Usually associated with diffuse hyperpigmentation, so looks like a very large squishy café au lait spot | |||
* Solitary lesions and not related to any inherited condition | * Solitary lesions and not related to any inherited condition | ||
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* Common | * Common | ||
* Usually isolated [[tumors]] in the [[muscle]] | * Usually isolated [[tumors]] in the [[muscle]] | ||
* Sometimes can occur | * Growths along very small nerves | ||
* Causes pain sometimes | |||
* Can be removed (leaves a scar behind) | |||
* Sometimes can occur as [[Plexiform neurofibroma|plexiform neurofibromas]] in form of chains or networks | |||
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| style="background:#DCDCDC;" align="center" + |[[Plexiform neurofibroma|Plexiform]]/Intraneural | | style="background:#DCDCDC;" align="center" + |[[Plexiform neurofibroma|Plexiform]]/Intraneural | ||
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* Associated with NF1 | * Associated with NF1 | ||
* Diffuse involvement along a | * Diffuse involvement along a large nerve and its branches | ||
* Have more [[connective tissue]] that separates the [[nerve fibers]] | * Mostly internal/ intraneural | ||
* Can also involve small nerves and superficial skin | |||
* Have more [[connective tissue]]/extracellular matrix than cutaneous neurofibromas, that separates the [[nerve fibers]] | |||
* Gross enlargement of the nerve with nodular tumor development results in the gross pathologic appearance referred to as “bag of worms” | * Gross enlargement of the nerve with nodular tumor development results in the gross pathologic appearance referred to as “bag of worms” | ||
* Generally believed to be present at [[birth]] | * Generally believed to be present at [[birth]] (congenital) | ||
* Disfiguring | * Disfiguring | ||
* Affects function due to sheer size as well as neurovascular compromise | * Affects function due to sheer size as well as neurovascular compromise | ||
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* It extends through the [[skin]] into [[fascia]] and [[muscle]] | * It extends through the [[skin]] into [[fascia]] and [[muscle]] | ||
* Lacks clear margins | |||
* Has “little [[fingers]]” that invade [[muscle]] or other [[Tissue (biology)|tissue]] | * Has “little [[fingers]]” that invade [[muscle]] or other [[Tissue (biology)|tissue]] | ||
* May not be easy to see in infants | |||
* May have a large [[café au lait spot]] “above” it | * May have a large [[café au lait spot]] “above” it | ||
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| style="background:#DCDCDC;" align="center" + |[[Nodular]] [[Plexiform neurofibroma|Plexiform]] | | style="background:#DCDCDC;" align="center" + |[[Nodular]] [[Plexiform neurofibroma|Plexiform]] | ||
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* Usually involves [[nerves]] coming off the [[spinal cord]] or off of larger [[nerves]] | * Usually involves [[nerves]] coming off the [[spinal cord]] or off of larger [[nerves]] (such as [[sciatic nerve]]) | ||
* Usually enlarges or thickens the [[nerve]] | * Usually enlarges or thickens the [[nerve]] | ||
* Looks like little [[Cluster (epidemiology)|clusters]] of [[tumors]] along the [[nerve]] | * Looks like little [[Cluster (epidemiology)|clusters]] of [[tumors]] along the [[nerve]] | ||
Revision as of 15:41, 26 March 2019
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Neurofibroma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Neurofibroma classification On the Web |
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American Roentgen Ray Society Images of Neurofibroma classification |
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Risk calculators and risk factors for Neurofibroma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]
Overview
Neurofibroma may be classified into 5 subtypes: cutaneous/dermal/localized, subcutaneous, diffuse, intramuscular, and plexiform neurofibroma. Plexiform neurofibromas may be further sub-classified into diffuse and nodular plexiform.
Classification
Neurofibroma may be classified into following 5 subtypes:[1][2]
| Types of neurofibromas | Characteristics/Description |
|---|---|
| Cutaneous/Dermal/Localized (90%) |
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| Subcutaneous |
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| Diffuse |
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| Intramuscular |
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| Plexiform/Intraneural |
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Plexiform neurofibromas can be further subclassified into following:[3]
| Types of neurofibromas | Characteristics/Description |
|---|---|
| Diffuse Plexiform | |
| Nodular Plexiform |
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References
- ↑ Neurofibroma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Neurofibroma#cite_note-pmid15486243-2 Accessed on November 17, 2015
- ↑ https://www.nfmidwest.org/
- ↑ https://www.nfmidwest.org/