Proteus syndrome: Difference between revisions
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=== Discovery === | === Discovery === | ||
* Proteus syndrome was first discovered by Frederick Treves, a British surgeon, in 1884. | * Proteus syndrome was first discovered by Frederick Treves, a British surgeon, in 1884. | ||
* Frederick Treves showed the proteus syndrome on Joseph Merrick, who used to be called as the famous Elephant Man, to the Pathological Society of London. | * Frederick Treves showed the proteus syndrome on Joseph Merrick, who used to be called as the famous Elephant Man, to the Pathological Society of London. | ||
* | * | ||
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==[[Proteus syndromeclassification|Classification]]== | ==[[Proteus syndromeclassification|Classification]]== | ||
* Proteus syndrome is one of the syndromes which falls under [[PTEN (gene)|PTEN]] [[hamartoma]] [[tumor]] syndromes (PHTS). PHTS are due to [[Germline mutation|germline mutations]] in [[PTEN (gene)|PTEN]] gene. | * Proteus syndrome is one of the syndromes which falls under [[PTEN (gene)|PTEN]] [[hamartoma]] [[tumor]] syndromes (PHTS). PHTS are due to [[Germline mutation|germline mutations]] in [[PTEN (gene)|PTEN]] gene. | ||
* PTEN hamartoma tumor syndromes (PHTS) which include the following: | * PTEN hamartoma tumor syndromes (PHTS) which include the following:<ref name="pmid30929792">{{cite journal |vauthors=Tibbles JA, Cohen MM |title=The Proteus syndrome: the Elephant Man diagnosed |journal=Br Med J (Clin Res Ed) |volume=293 |issue=6548 |pages=683–5 |date=September 1986 |pmid=3092979 |pmc=1341524 |doi= |url=}}</ref> | ||
** Proteus syndrome | ** Proteus syndrome | ||
** [[Cowden syndrome]] | ** [[Cowden syndrome]] | ||
Revision as of 13:02, 28 March 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Synonyms and keywords:PS
Overview
Proteus syndrome is an exceedingly rare disorder which falls under the category of hamartomatous disorder. Proteus syndrome is a very complex disorder which involves multiple organ systems in the body.
Historical Perspective
Discovery
- Proteus syndrome was first discovered by Frederick Treves, a British surgeon, in 1884.
- Frederick Treves showed the proteus syndrome on Joseph Merrick, who used to be called as the famous Elephant Man, to the Pathological Society of London.
Classification
- Proteus syndrome is one of the syndromes which falls under PTEN hamartoma tumor syndromes (PHTS). PHTS are due to germline mutations in PTEN gene.
- PTEN hamartoma tumor syndromes (PHTS) which include the following:[1]