Neurofibroma laboratory findings: Difference between revisions
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*Positive for: | *Positive for: | ||
**[[S100A1|S100]] | **[[S100A1|S100]] | ||
**Sox10 | |||
**[[CD34]] (focal) | **[[CD34]] (focal) | ||
**Factor XIIIa (focal) | **Factor XIIIa (focal) | ||
**Neurofilament (and Bielshowsky) | |||
**GFAP | |||
**Calretinin (focal) | |||
*Negative for: | *Negative for: | ||
**EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]]) | **EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]]) | ||
| Line 19: | Line 23: | ||
**Caldesmon | **Caldesmon | ||
**p53 | **p53 | ||
{| class="wikitable" | |||
|+Immunohistochemical differences between Neurofibroma and Schwannoma | |||
!Immunohistochemical stain | |||
!Neurofibroma | |||
!Schwannoma | |||
|- | |||
|'''S-100 and Sox10''' | |||
|Moderate positivity | |||
|Strong, diffuse positivity | |||
|- | |||
|'''CD34''' | |||
|Moderate | |||
|Scattered cells in Antoni B areas | |||
|- | |||
|'''Neurofilament (and Bielshowsky)''' | |||
|Stains entrapped axons within lesion | |||
|Stains peripherally located axons of parent nerve | |||
|- | |||
|'''Factor XIIIa''' | |||
|Moderate | |||
|Negative to focal | |||
|- | |||
|'''Calretinin''' | |||
|Negative to focal | |||
|Moderate | |||
|- | |||
|'''GFAP''' | |||
|Variable, weak | |||
|Variable, moderate | |||
|} | |||
==References== | ==References== | ||
Revision as of 16:38, 29 March 2019
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Neurofibroma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Neurofibroma laboratory findings On the Web |
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American Roentgen Ray Society Images of Neurofibroma laboratory findings |
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Risk calculators and risk factors for Neurofibroma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Immunohistochemistry of neurofibroma shows positivity for S100, CD34, and factor XIIIa and negativity for EMA (except in plexiform neurofibromas).
Laboratory Findings
Immunohistochemistry of neurofibroma is as follows:
- Positive for:
- Negative for:
- EMA (except in plexiform neurofibromas)
- Keratin
- Smooth muscle actin
- Desmin
- Calponin
- Caldesmon
- p53
| Immunohistochemical stain | Neurofibroma | Schwannoma |
|---|---|---|
| S-100 and Sox10 | Moderate positivity | Strong, diffuse positivity |
| CD34 | Moderate | Scattered cells in Antoni B areas |
| Neurofilament (and Bielshowsky) | Stains entrapped axons within lesion | Stains peripherally located axons of parent nerve |
| Factor XIIIa | Moderate | Negative to focal |
| Calretinin | Negative to focal | Moderate |
| GFAP | Variable, weak | Variable, moderate |