Osteosarcoma risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
The most common risk factors for osteosarcoma include: | |||
Teenage growth spurts | |||
Being tall for a specific age | |||
Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation | |||
Presence of certain benign (noncancerous) bone diseases | |||
Presence of certain rare, inherited disorders, such as the following: | |||
Li-Fraumeni syndrome. A rare family predisposition to multiple types of cancers, including soft tissue sarcomas, breast cancer, brain tumors and osteosarcoma. This condition is caused by a mutation in the p53 tumor-suppressor gene, which normally curbs cancer growth. | |||
Rothmund-Thomson syndrome. A rare, inherited syndrome that includes skeletal problems, rashes, short stature and an increased risk of developing osteosarcoma. It is caused by an abnormality in the RECQL4 gene. | |||
Hereditary retinoblastoma. A cancer of the eye that usually happens in children under age 4. | |||
Common risk factors in development of osteosarcoma are: | Common risk factors in development of osteosarcoma are: | ||
*[[Age]] and [[height]]: data suggest that the risk of osteosarcoma is highest during the teenage "[[growth spurt]]." Children with osteosarcoma are usually tall for their age | *[[Age]] and [[height]]: data suggest that the risk of osteosarcoma is highest during the teenage "[[growth spurt]]." Children with osteosarcoma are usually tall for their age | ||
Revision as of 21:45, 2 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
Overview
Common risk factors in the development of osteosarcoma are radiation to bones, alkylating antineoplastic agents, Paget disease, multiple hereditary osteochondromas, fibrous dysplasia, Bloom syndrome,Rothmund-Thomson syndrome, and Li-Fraumeni syndrome.
Risk Factors
The most common risk factors for osteosarcoma include:
Teenage growth spurts
Being tall for a specific age
Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
Presence of certain benign (noncancerous) bone diseases
Presence of certain rare, inherited disorders, such as the following:
Li-Fraumeni syndrome. A rare family predisposition to multiple types of cancers, including soft tissue sarcomas, breast cancer, brain tumors and osteosarcoma. This condition is caused by a mutation in the p53 tumor-suppressor gene, which normally curbs cancer growth.
Rothmund-Thomson syndrome. A rare, inherited syndrome that includes skeletal problems, rashes, short stature and an increased risk of developing osteosarcoma. It is caused by an abnormality in the RECQL4 gene.
Hereditary retinoblastoma. A cancer of the eye that usually happens in children under age 4.
Common risk factors in development of osteosarcoma are:
- Age and height: data suggest that the risk of osteosarcoma is highest during the teenage "growth spurt." Children with osteosarcoma are usually tall for their age
- Radiation to bones: people who were treated with radiation for another cancer have a higher risk of later developing post-radiation (after radiation) osteosarcoma
- Drugs: past treatment with anticancer drugs called alkylating antineoplastic agents
- Certain bone diseases:
- Paget disease of bone
- Multiple hereditary osteochondromas
- Fibrous dysplasia
- Enchondromtosis
- Inherited cancer syndromes: Genetic diseases that predispose to osteosarcoma are:[1]
References
- ↑ Osteosarcoma. Dr Amir Rezaee ◉ and Dr Frank Gaillard ◉ et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/osteosarcoma