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==Risk Factors==
==Risk Factors==
The most common risk factors for osteosarcoma include:
The most common risk factors for osteosarcoma include:
 
* Teenage growth spurts
Teenage growth spurts
* Being tall
 
* Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
Being tall for a specific age
* Drugs: past treatment with anticancer drugs called [[alkylating antineoplastic agents]]
 
* Presence of certain benign (noncancerous) bone diseases, such as:
Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
#[[Paget disease]] of bone
 
#Multiple hereditary [[osteochondromas]]
Presence of certain benign (noncancerous) bone diseases
#[[Fibrous dysplasia]]
 
#Enchondromtosis
Presence of certain rare, inherited disorders, such as the following:
* Presence of certain rare, inherited disorders, such as:
 
# [[Bloom syndrome]]
Li-Fraumeni syndrome. A rare family predisposition to multiple types of cancers, including soft tissue sarcomas, breast cancer, brain tumors and osteosarcoma. This condition is caused by a mutation in the p53 tumor-suppressor gene, which normally curbs cancer growth.
#[[Diamond-Blackfan anemia]]
 
#[[Familial adenomatous polyposis]]
Rothmund-Thomson syndrome. A rare, inherited syndrome that includes skeletal problems, rashes, short stature and an increased risk of developing osteosarcoma. It is caused by an abnormality in the RECQL4 gene. 
#[[Li-Fraumeni syndrome]]
 
#[[Retinoblastoma|Hereditary retinoblastoma]]
Hereditary retinoblastoma. A cancer of the eye that usually happens in children under age 4.
#[[Rothmund-Thomson syndrome]]
 
#[[Werner syndrome]]
Common risk factors in development of osteosarcoma are:
*[[Age]] and [[height]]: data suggest that the risk of osteosarcoma is highest during the teenage "[[growth spurt]]." Children with osteosarcoma are usually tall for their age
*[[Radiation therapy|Radiation]] to bones: people who were treated with [[radiation]] for another cancer have a higher risk of later developing post-radiation (after radiation) osteosarcoma
*Drugs: past treatment with anticancer drugs called [[alkylating antineoplastic agents]]
*Certain bone diseases:
:*[[Paget disease]] of bone
:*Multiple hereditary [[osteochondromas]]
:*[[Fibrous dysplasia]]
:*Enchondromtosis
*Inherited cancer syndromes: Genetic diseases that predispose to osteosarcoma are:<ref name="radio2">Osteosarcoma. Dr Amir Rezaee ◉ and Dr Frank Gaillard ◉ et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/osteosarcoma</ref>
:*[[Bloom syndrome]]
:*[[Diamond-Blackfan anemia]]
:*[[Familial adenomatous polyposis]]
:*[[Li-Fraumeni syndrome]]
:*[[Retinoblastoma|Hereditary retinoblastoma]]
:*[[Rothmund-Thomson syndrome]]
:*[[Werner syndrome]]


==References==
==References==

Revision as of 21:49, 2 April 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

Overview

Common risk factors in the development of osteosarcoma are radiation to bones, alkylating antineoplastic agents, Paget disease, multiple hereditary osteochondromas, fibrous dysplasia, Bloom syndrome,Rothmund-Thomson syndrome, and Li-Fraumeni syndrome.

Risk Factors

The most common risk factors for osteosarcoma include:

  • Teenage growth spurts
  • Being tall
  • Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
  • Drugs: past treatment with anticancer drugs called alkylating antineoplastic agents
  • Presence of certain benign (noncancerous) bone diseases, such as:
  1. Paget disease of bone
  2. Multiple hereditary osteochondromas
  3. Fibrous dysplasia
  4. Enchondromtosis
  • Presence of certain rare, inherited disorders, such as:
  1. Bloom syndrome
  2. Diamond-Blackfan anemia
  3. Familial adenomatous polyposis
  4. Li-Fraumeni syndrome
  5. Hereditary retinoblastoma
  6. Rothmund-Thomson syndrome
  7. Werner syndrome

References

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