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==Overview==
==Overview==
Extamammary Paget's disease (EMPD) is a rare non-melanocytic intraepidermal skin lesion. It usually involves the [[epidermis]], but occasionally extends into the underlying dermis. It has predilection for [[apocrine gland]]-bearing areas: mostly the [[perineum]], [[vulva]], [[axilla]], [[scrotum]] and [[penis]]. Extramammary Paget's disease may be classified into two groups based on the origin of the [[Paget's cells]]. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected.<ref name="pmid12094382">{{cite journal| author=Wilkinson EJ, Brown HM| title=Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. | journal=Hum Pathol | year= 2002 | volume= 33 | issue= 5 | pages= 549-54 | pmid=12094382 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12094382  }} </ref> On gross pathology, plaque with an irregular border and [[erythematous]] or white lesion are characteristic findings of extramammary Paget's disease. On microscopic histopathological analysis, The presence of Paget's cells (large cells with abundant amphophilic or [[basophilic]], finely granular cytoplasm and a large, centrally-located nucleus and prominent nucleolus) and signet ring cells are characteristic findings of extramammary Paget's disease. Extramammary Paget's disease is usually associated with adnexal apocrine carcinoma, which represents infiltration of the deeper adnexa by epidermal Paget cells.<ref name="pmid19888952">{{cite journal| author=Roy J, Mirnezami A, Gatt M, Sasapu KK, Scott N, Sagar PM| title=A rare case of Paget's disease in a retrorectal dermoid cyst. | journal=Colorectal Dis | year= 2010 | volume= 12 | issue= 9 | pages= 946-7 | pmid=19888952 | doi=10.1111/j.1463-1318.2009.02102.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19888952  }} </ref><ref name="librepathology">Ameloblastoma. Libre pathology(2015) http://librepathology.org/wiki/index.php/Extramammary_Paget_disease#Microscopic Accessed on January 30, 2016</ref> Neither the direct cause nor a prominent risk factor of extramammary Paget's disease has been identified.<ref>Lever, Walter F., and David E. Elder. Lever's histopathology of the skin. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009.</ref><ref name="pmid11064666">{{cite journal| author=Lloyd J, Flanagan AM| title=Mammary and extramammary Paget's disease. | journal=J Clin Pathol | year= 2000 | volume= 53 | issue= 10 | pages= 742-9 | pmid=11064666 | doi= | pmc=PMC1731095 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11064666  }} </ref><ref>Mehregan, Amir H., and Hermann Pinkus. Pinkus' guide to dermatohistopathology. Norwalk, Conn: Appleton-Century-Crofts, 1986. Print.</ref><ref name="OrlandiPiccione2001">{{cite journal|last1=Orlandi|first1=A.|last2=Piccione|first2=E.|last3=Francesconi|first3=A.|last4=Spagnoli|first4=L. G.|title=Simultaneous vulvar intraepithelial neoplasia and Paget's disease: Report of two cases|journal=International Journal of Gynecological Cancer|volume=11|issue=3|year=2001|pages=224–228|issn=1048-891X|doi=10.1046/j.1525-1438.2001.01016.x}}</ref> Extramammary Paget's disease is rare and the exact incidence is unknown. Extramammary Paget's disease commonly affects individuals 50-60 years of age. Females are more commonly affected with the disease than males. The female to male ratio is approximately 3-4.5 to 1. It usually affects individuals of the Caucasian race, but it may occur in other races.<ref name="pmid3001158">{{cite journal| author=Chanda JJ| title=Extramammary Paget's disease: prognosis and relationship to internal malignancy. | journal=J Am Acad Dermatol | year= 1985 | volume= 13 | issue= 6 | pages= 1009-14 | pmid=3001158 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3001158  }} </ref> Symptoms of extramammary Paget's disease include [[pruritis]], vulvar pain, vulvar bleeding, and burning sensation.<ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref><ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709  }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912  }} </ref> Biopsy is diagnostic of extramammary Paget's disease. Other diagnostic studies for extramammary Paget's disease include [[fine needle aspirate]] and [[PAP]] smear. Treatment depends on the stage at diagnosis. Treatment often includes surgery and chemotherapy with either 5-fluorouracil, imiquimod, or combination of paclitaxel and trastuzumab.
Extamammary Paget's disease (EMPD) is a rare non-melanocytic [[Epidermal|intraepidermal]] skin lesion. It usually involves the [[epidermis]], but occasionally extends into the underlying dermis. It has predilection for [[apocrine gland]]-bearing areas: mostly the [[perineum]], [[vulva]], [[axilla]], [[scrotum]] and [[penis]]. Extramammary Paget's disease may be classified into two groups based on the origin of the [[Paget's cells]]. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected.<ref name="pmid12094382">{{cite journal| author=Wilkinson EJ, Brown HM| title=Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. | journal=Hum Pathol | year= 2002 | volume= 33 | issue= 5 | pages= 549-54 | pmid=12094382 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12094382  }} </ref> On gross pathology, plaque with an irregular border and [[erythematous]] or white lesion are characteristic findings of extramammary Paget's disease. On microscopic histopathological analysis, The presence of Paget's cells (large cells with abundant amphophilic or [[basophilic]], finely granular cytoplasm and a large, centrally-located nucleus and prominent nucleolus) and signet ring cells are characteristic findings of extramammary Paget's disease. Extramammary Paget's disease is usually associated with adnexal apocrine carcinoma, which represents infiltration of the deeper adnexa by epidermal Paget cells.<ref name="pmid19888952">{{cite journal| author=Roy J, Mirnezami A, Gatt M, Sasapu KK, Scott N, Sagar PM| title=A rare case of Paget's disease in a retrorectal dermoid cyst. | journal=Colorectal Dis | year= 2010 | volume= 12 | issue= 9 | pages= 946-7 | pmid=19888952 | doi=10.1111/j.1463-1318.2009.02102.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19888952  }} </ref><ref name="librepathology">Ameloblastoma. Libre pathology(2015) http://librepathology.org/wiki/index.php/Extramammary_Paget_disease#Microscopic Accessed on January 30, 2016</ref> Neither the direct cause nor a prominent risk factor of extramammary Paget's disease has been identified.<ref>Lever, Walter F., and David E. Elder. Lever's histopathology of the skin. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009.</ref><ref name="pmid11064666">{{cite journal| author=Lloyd J, Flanagan AM| title=Mammary and extramammary Paget's disease. | journal=J Clin Pathol | year= 2000 | volume= 53 | issue= 10 | pages= 742-9 | pmid=11064666 | doi= | pmc=PMC1731095 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11064666  }} </ref><ref>Mehregan, Amir H., and Hermann Pinkus. Pinkus' guide to dermatohistopathology. Norwalk, Conn: Appleton-Century-Crofts, 1986. Print.</ref><ref name="OrlandiPiccione2001">{{cite journal|last1=Orlandi|first1=A.|last2=Piccione|first2=E.|last3=Francesconi|first3=A.|last4=Spagnoli|first4=L. G.|title=Simultaneous vulvar intraepithelial neoplasia and Paget's disease: Report of two cases|journal=International Journal of Gynecological Cancer|volume=11|issue=3|year=2001|pages=224–228|issn=1048-891X|doi=10.1046/j.1525-1438.2001.01016.x}}</ref> Extramammary Paget's disease is rare and the exact incidence is unknown. Extramammary Paget's disease commonly affects individuals 50-60 years of age. Females are more commonly affected with the disease than males. The female to male ratio is approximately 3-4.5 to 1. It usually affects individuals of the Caucasian race, but it may occur in other races.<ref name="pmid3001158">{{cite journal| author=Chanda JJ| title=Extramammary Paget's disease: prognosis and relationship to internal malignancy. | journal=J Am Acad Dermatol | year= 1985 | volume= 13 | issue= 6 | pages= 1009-14 | pmid=3001158 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3001158  }} </ref> Symptoms of extramammary Paget's disease include [[pruritis]], vulvar pain, vulvar bleeding, and burning sensation.<ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref><ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709  }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912  }} </ref> Biopsy is diagnostic of extramammary Paget's disease. Other diagnostic studies for extramammary Paget's disease include [[fine needle aspirate]] and [[PAP]] smear. Treatment depends on the stage at diagnosis. Treatment often includes surgery and chemotherapy with either 5-fluorouracil, imiquimod, or combination of paclitaxel and trastuzumab.


==Historical Perspective==
==Historical Perspective==

Revision as of 13:28, 9 April 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Extamammary Paget's disease (EMPD) is a rare non-melanocytic intraepidermal skin lesion. It usually involves the epidermis, but occasionally extends into the underlying dermis. It has predilection for apocrine gland-bearing areas: mostly the perineum, vulva, axilla, scrotum and penis. Extramammary Paget's disease may be classified into two groups based on the origin of the Paget's cells. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected.[1] On gross pathology, plaque with an irregular border and erythematous or white lesion are characteristic findings of extramammary Paget's disease. On microscopic histopathological analysis, The presence of Paget's cells (large cells with abundant amphophilic or basophilic, finely granular cytoplasm and a large, centrally-located nucleus and prominent nucleolus) and signet ring cells are characteristic findings of extramammary Paget's disease. Extramammary Paget's disease is usually associated with adnexal apocrine carcinoma, which represents infiltration of the deeper adnexa by epidermal Paget cells.[2][3] Neither the direct cause nor a prominent risk factor of extramammary Paget's disease has been identified.[4][5][6][7] Extramammary Paget's disease is rare and the exact incidence is unknown. Extramammary Paget's disease commonly affects individuals 50-60 years of age. Females are more commonly affected with the disease than males. The female to male ratio is approximately 3-4.5 to 1. It usually affects individuals of the Caucasian race, but it may occur in other races.[8] Symptoms of extramammary Paget's disease include pruritis, vulvar pain, vulvar bleeding, and burning sensation.[9][10][11] Biopsy is diagnostic of extramammary Paget's disease. Other diagnostic studies for extramammary Paget's disease include fine needle aspirate and PAP smear. Treatment depends on the stage at diagnosis. Treatment often includes surgery and chemotherapy with either 5-fluorouracil, imiquimod, or combination of paclitaxel and trastuzumab.

Historical Perspective

Extramammary Paget's disease was first discovered by Radcliffe Crocker in 1889.[12]

Classification

Extramammary Paget's disease may be classified into two groups based on the origin of the Paget's cells. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected.[1]

Pathophysiology

On gross pathology, plaque with an irregular border and erythematous or white lesion are characteristic findings of extramammary Paget's disease. On microscopic histopathological analysis, Paget's cells which are large cells with abundant amphophilic or basophilic, finely granular cytoplasm, the nucleus which is usually large, centrally situated, and sometimes contains a prominent nucleolus, and signet ring cells are characteristic findings of extramammary Paget's disease. Extramammary Paget's disease arises from keratinocytic stem cells or from apocrine gland ducts. Approximately 25% (range 9-32%) of the cases of extramammary Paget's disease are associated with an underlying in situ or invasive neoplasm. Extramammary Paget's disease is usually associated with adnexal apocrine carcinoma, which represents infiltration of the deeper adnexa by epidermal Paget cells.

Causes

The cause of extramammary Paget's disease has not been identified.[13][5][14][7]

Differential Diagnosis

Extramammary Paget's disease must be differentiated from basal cell carcinoma, Bowen's disease, cutaneous candidiasis, intertrigo, irritant contact dermatitis, lichen simplex chronicus, plaque psoriasis, tinea cruris, seborrhoeic dermatitis, lichen sclerosis, anogenital intraepithelial neoplasia, melanoma, histiocytosis, mycosis fungoides, leukoplakia, squamous cell carcinoma, condylomata accuminata, Crohn's disease, and hidradenitis suppurativa.[15]

Epidemiology and Demographics

Extramammary Paget's disease is rare, and its exact incidence is unknown. Extramammary Paget's disease commonly affects individuals 50-60 years of age. Females are more commonly affected with the disease than males. The female to male ratio is approximately 3-4.5 to 1. It usually affects individuals of the Caucasian race, but it may occur in other races.[8]

Risk Factors

There are no established risk factors for extramammary Paget's disease.

Screening

According to the United States Preventive Services Task Force, screening for extramammary Paget's disease is not recommended among the general population.[16]

Natural History, Complications and Prognosis

If left untreated, the disease is usually progressive. Common complications of extramammary Paget's disease include recurrence of the tumor and metastasis. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. The prognosis for primary Extramammary Pagets's disease confined to the epidermis is excellent. However, invasive primary extramammary Paget's disease carries a poor prognosis, particularly if lymphovascular invasion is present.[17][18][19][5][20][21]

Diagnosis

History and Symptoms

Symptoms of extramammary Paget's disease include pruritis, vulvar pain, vulvar bleeding, and burning sensation.[9][10][11]

Physical Examination

Common physical examination findings of extramammary Paget's disease include well demarcated, erythematous or leucoplakic plaques present on the skin, characteristic ‘cake-icing’ appearance of vulval extramammary Paget's disease (erythematous changes associated with white islands and bridges of hyperkeratotic epithelium), and lymphadenopathy.[22][23]

Chest X Ray

Chest x-rays may be performed to detect metastases of extramammary Paget's disease to the lungs.

CT

Chest, abdomen, and pelvic CT scan may be helpful in the diagnosis of extramammary Paget's disease. CT scan can confirm the exact location of the cancer and show the organs nearby, as well as lymph nodes and distant organs where the cancer might have spread.

MRI

Chest, abdomen, and pelvic MRI scan may be helpful in the diagnosis of EMPD.

Other Imaging Findings

Other imaging studies for EMPD include bone scan, ultrasound scan, PET scan, cystoscopy, sigmoidoscopy, colonoscopy, mammography, and colposcopy, which demonstrates metastases and underlying invasive carcinomas.[8][24]

Other Diagnostic Studies

Biopsy is diagnostic of extramammary Paget's disease. Other diagnostic studies for extramammary Paget's disease include fine needle aspirate and PAP smear.

Treatment

Medical Therapy

Treatment depends on the stage at diagnosis. Chemotherapy with either 5-fluorouracil, imiquimod, or combination of paclitaxel and trastuzumab has been evaluated for the treatment of extramammary Paget's disease.

Surgery

Surgery is the first line treatment for extramammary Paget's disease.

Primary Prevention

There are no primary preventive measures against extramammary Paget's disease.

Secondary Prevention

Secondary prevention strategies following extramammary Paget's disease include an annual complete physical examination, proctosigmoidoscopy and punch biopsy of any new lesion. Colonoscopy should be carried out at every two to three year intervals.[25]

References

  1. ↑ 1.0 1.1 Wilkinson EJ, Brown HM (2002). "Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease". Hum Pathol. 33 (5): 549–54. PMID 12094382.
  2. ↑ Roy J, Mirnezami A, Gatt M, Sasapu KK, Scott N, Sagar PM (2010). "A rare case of Paget's disease in a retrorectal dermoid cyst". Colorectal Dis. 12 (9): 946–7. doi:10.1111/j.1463-1318.2009.02102.x. PMID 19888952.
  3. ↑ Ameloblastoma. Libre pathology(2015) http://librepathology.org/wiki/index.php/Extramammary_Paget_disease#Microscopic Accessed on January 30, 2016
  4. ↑ Lever, Walter F., and David E. Elder. Lever's histopathology of the skin. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009.
  5. ↑ 5.0 5.1 5.2 Lloyd J, Flanagan AM (2000). "Mammary and extramammary Paget's disease". J Clin Pathol. 53 (10): 742–9. PMC 1731095. PMID 11064666.
  6. ↑ Mehregan, Amir H., and Hermann Pinkus. Pinkus' guide to dermatohistopathology. Norwalk, Conn: Appleton-Century-Crofts, 1986. Print.
  7. ↑ 7.0 7.1 Orlandi, A.; Piccione, E.; Francesconi, A.; Spagnoli, L. G. (2001). "Simultaneous vulvar intraepithelial neoplasia and Paget's disease: Report of two cases". International Journal of Gynecological Cancer. 11 (3): 224–228. doi:10.1046/j.1525-1438.2001.01016.x. ISSN 1048-891X.
  8. ↑ 8.0 8.1 8.2 Chanda JJ (1985). "Extramammary Paget's disease: prognosis and relationship to internal malignancy". J Am Acad Dermatol. 13 (6): 1009–14. PMID 3001158.
  9. ↑ 9.0 9.1 Zollo, J.D.; Zeitouni, N.C. (2000). "The Roswell Park Cancer Institute experience with extramammary Paget's disease". British Journal of Dermatology. 142 (1): 59–65. doi:10.1046/j.1365-2133.2000.03242.x. ISSN 0007-0963.
  10. ↑ 10.0 10.1 Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J; et al. (2000). "Paget's disease of the vulva: pathology, pattern of involvement, and prognosis". Gynecol Oncol. 77 (1): 183–9. doi:10.1006/gyno.2000.5741. PMID 10739709.
  11. ↑ 11.0 11.1 Tebes S, Cardosi R, Hoffman M (2002). "Paget's disease of the vulva". Am J Obstet Gynecol. 187 (2): 281–3, discussion 283-4. PMID 12193912.
  12. ↑ extramammary Paget's disease. Wikipedia(2015) https://en.wikipedia.org/wiki/Extramammary_Paget%27s_disease Accessed on January 26, 2016
  13. ↑ Lever, Walter F., and David E. Elder. Lever's histopathology of the skin. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009.
  14. ↑ Mehregan, Amir H., and Hermann Pinkus. Pinkus' guide to dermatohistopathology. Norwalk, Conn: Appleton-Century-Crofts, 1986. Print.
  15. ↑ Balducci L, Crawford ED, Smith GF, Lambuth B, McGehee R, Hardy C (1988). "Extramammary Paget's disease: an annotated review". Cancer Invest. 6 (3): 293–303. PMID 2844363.
  16. ↑ http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=extramammary+pagets+disease Accessed on January 26, 2016.
  17. ↑ Goldblum JR, Hart WR (1997). "Vulvar Paget's disease: a clinicopathologic and immunohistochemical study of 19 cases". Am J Surg Pathol. 21 (10): 1178–87. PMID 9331290.
  18. ↑ Goldblum JR, Hart WR (1998). "Perianal Paget's disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma". Am J Surg Pathol. 22 (2): 170–9. PMID 9500217.
  19. ↑ DeVita, Vincent T., Theodore S. Lawrence, and Steven A. Rosenberg. DeVita, Hellman, and Rosenberg's cancer : principles & practice of oncology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2011. Print.
  20. ↑ Mann, J.; Lavaf, A.; Tejwani, A.; Ross, P.; Ashamalla, H. (2012). "Perianal Paget disease treated definitively with radiotherapy". Current Oncology. 19 (6). doi:10.3747/co.19.1144. ISSN 1198-0052.
  21. ↑ Moretto, P.; Nair, V.J.; El Hallani, S.; Malone, S.; Belanger, E.; Morash, C.; Canil, C.M. (2013). "Management of penoscrotal extramammary Paget disease: case series and review of the literature". Current Oncology. 20 (4): 311. doi:10.3747/co.20.1353. ISSN 1718-7729.
  22. ↑ Heymann WR (1993). "Extramammary Paget's disease". Clin Dermatol. 11 (1): 83–7. PMID 8393362.
  23. ↑ Silverberg, Steven G., and Ronald A. DeLellis. Silverberg's principles and practice of surgical pathology and cytopathology. Edinburgh: Churchill Livingstone/Elsevier, 2006. Print.
  24. ↑ Cho SB, Yun M, Lee MG, Chung KY (2005). "Variable patterns of positron emission tomography in the assessment of patients with extramammary Paget's disease". J Am Acad Dermatol. 52 (2): 353–5. doi:10.1016/j.jaad.2004.10.864. PMID 15692486.
  25. ↑ Sarmiento JM, Wolff BG, Burgart LJ, Frizelle FA, Ilstrup DM (1997). "Paget's disease of the perianal region--an aggressive disease?". Dis Colon Rectum. 40 (10): 1187–94. PMID [ 9336114 [ Check |pmid= value (help).


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