Carcinoma of the penis differential diagnosis: Difference between revisions
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:**PeIN on the [[glans]] ([[Penis|head]]) or [[foreskin]] of the [[penis]] is also called [[erythroplasia of Queyrat]] | :**PeIN on the [[glans]] ([[Penis|head]]) or [[foreskin]] of the [[penis]] is also called [[erythroplasia of Queyrat]] | ||
:**PeIN on the [[shaft]] of the [[penis]] is also called [[Bowen’s disease]] | :**PeIN on the [[shaft]] of the [[penis]] is also called [[Bowen’s disease]] | ||
:* [[Balanitis xerotica obliterans]] (BXO) also known as [[Lichen sclerosus|lichen sclerosis]] | :* [[Balanitis xerotica obliterans]] ([[Balanitis xerotica obliterans|BXO]]) also known as [[Lichen sclerosus|lichen sclerosis]] | ||
:**A [[precancerous]] [[skin]] [[condition]] localized to the [[glans]] and the [[prepuce]] | :**A [[precancerous]] [[skin]] [[condition]] localized to the [[glans]] and the [[prepuce]] | ||
:**Presents as white [[atrophic]] patches | :**Presents as white [[atrophic]] patches | ||
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:**A radical [[Circumcised|circumcision]] should therefore be performed for this [[disease]] | :**A radical [[Circumcised|circumcision]] should therefore be performed for this [[disease]] | ||
:* Buschke-Lowenstein tumour | :* Buschke-Lowenstein tumour | ||
:**A slow-growing, locally destructive verrucous plaque | :**A [[slow]]-[[Growth|growing]], [[Local|locally]] destructive [[Verrucous carcinoma|verrucous]] [[plaque]] | ||
:**Cauliflower-like mass | :**Cauliflower-like [[mass]] | ||
:**A regional variant of verrucous carcinoma, also known as giant condyloma acuminate | :**A regional variant of [[verrucous carcinoma]], also known as giant [[condyloma]] acuminate | ||
:**Can involve the penis, vulva, scrotum, bladder, and perianal or anorectal regions | :**Can involve the [[penis]], [[vulva]], [[scrotum]], [[bladder]], and perianal or [[anorectal]] regions | ||
:**Rare | :**[[Rare]] | ||
:*Bowen's Disease | :*[[Bowen's disease|Bowen's Disease]] | ||
:**Undifferentiated PeIN | :**[[Undifferentiated]] PeIN | ||
:**Manifests as a solitary, pigmented, scaly or scab-covered area | :**Manifests as a [[solitary]], [[Pigmented lesions|pigmented]], scaly or [[scab]]-covered [[area]] | ||
:**Affects the penis shaft, scrotum, perineum, and the suprapubic area | :**Affects the [[penis]] shaft, [[scrotum]], [[perineum]], and the suprapubic [[area]] | ||
:* [[Bowenoid papulosis]] | :* [[Bowenoid papulosis]] | ||
:**Multiple, slightly elevated, red to violet or brownish papules, on the penis shaft and scrotum | :**Multiple, slightly elevated, red to violet or brownish papules, on the penis shaft and scrotum | ||
Revision as of 12:11, 10 April 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Swathi Venkatesan, M.B.B.S.[2]
Overview
Carcinoma of the penis must be differentiated from condyloma acuminata, penile intraepithelial neoplasia (PeIN), balanitis xerotica obliterans, buschke-Lowenstein tumour, bowenoid papulosis, and leukoplakia.
Differential Diagnosis
Carcinoma of the penis must be differentiated from:[1][2]
- Noncancerous conditions
- Condyloma acuminata
- A common sexually transmitted disease caused by a virus belonging to the human papilloma virus (HPV) group
- Lesions normally grow as a papilloma and are usually found on the glans, prepuce, or shaft of the penis
- Lesions are benign, caused by low-risk HPV 6/11
- Mixed infections with high-risk HPV types are relatively common
- Progression to malignancy is rare.
- Condyloma acuminata
- Precancerous conditions [3]
- Penile intraepithelial neoplasia (PeIN)
- most common precancerous condition of the penis
- General term used to describe precancerous conditions of the penis that may develop into invasive squamous cell carcinoma (SCC) if they are not treated
- Refers to abnormal cell changes, called carcinoma in situ, that occur on the skin surface of the penis
- PeIN on the glans (head) or foreskin of the penis is also called erythroplasia of Queyrat
- PeIN on the shaft of the penis is also called Bowen’s disease
- Balanitis xerotica obliterans (BXO) also known as lichen sclerosis
- A precancerous skin condition localized to the glans and the prepuce
- Presents as white atrophic patches
- The secondary development of phimosis inhibits washing and prevents early diagnostics of possible malignancy development on the glans or inside of the prepuce
- A radical circumcision should therefore be performed for this disease
- Buschke-Lowenstein tumour
- Bowen's Disease
- Bowenoid papulosis
- Multiple, slightly elevated, red to violet or brownish papules, on the penis shaft and scrotum
- Very rare, is preferably seen young men
- May regress without treatment
- Caused by high-risk HPV, most commonly HPV 16
- Histologically cannot be separated from undifferentiated PeIN
- Leukoplakia
- Rare
- Appear as a white hypertrophic or atrophic patch and usually occur secondary to chronic irritation
- Develops in the meatus
- Biopsy is necessary to exclude cancer and intraepithelial neoplasia (PeIN)
- Erythroplasia of Queyrat
- Grows on the glans and the prepuce
- Presents as a well-defined, red patch
- Undifferentiated PeIN
- Penile intraepithelial neoplasia (PeIN)
References
- ↑ Precancerous conditions of the penis. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/penile/penile-cancer/precancerous-conditions/?region=ab Accessed on September, 30 2015
- ↑ Differential diagnoses of penile cancer. Oncology Encyclopedia 2015.http://oncolex.org/penile-cancer/background/differentialdiagnoses Accessed on September, 30 2015
- ↑ "Differential diagnoses of penile cancer".