Extramammary Paget's disease history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Symptoms of extramammary Paget's disease include [[pruritus]], vulvar pain, vulvar [[bleeding]], and burning sensation.<ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref><ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709 }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912 }} </ref> | [[Symptom|Symptoms]] of extramammary Paget's disease include [[pruritus]], [[Vulva|vulvar]] pain, [[Vulva|vulvar]] [[bleeding]], and burning sensation.<ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref><ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709 }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912 }} </ref> | ||
==History== | ==History== | ||
In any patient with chronic dermatitis of the vulva, groin, or perianal are, the possibility of extramammary Paget disease (EMPD) should be carefully considered. Patients with EMPD usually present with nonresolving eczematous lesions in the genitalia, groin, [[perineum]], or perianal area.<ref name="pmid19846157">{{cite journal| author=Bagby CM, MacLennan GT| title=Extramammary Paget's disease of the penis and scrotum. | journal=J Urol | year= 2009 | volume= 182 | issue= 6 | pages= 2908-9 | pmid=19846157 | doi=10.1016/j.juro.2009.09.027 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19846157 }} </ref> | In any patient with [[Dermatitis|chronic dermatitis]] of the [[vulva]], [[groin]], or perianal are, the possibility of extramammary Paget disease (EMPD) should be carefully considered. Patients with EMPD usually present with nonresolving [[Eczematous Scaling|eczematous]] [[Lesion|lesions]] in the [[genitalia]], [[groin]], [[perineum]], or perianal area.<ref name="pmid19846157">{{cite journal| author=Bagby CM, MacLennan GT| title=Extramammary Paget's disease of the penis and scrotum. | journal=J Urol | year= 2009 | volume= 182 | issue= 6 | pages= 2908-9 | pmid=19846157 | doi=10.1016/j.juro.2009.09.027 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19846157 }} </ref> | ||
==Symptoms== | ==Symptoms== | ||
The disease is asymptomatic in 10% of patients. The average time interval from the onset of symptoms to diagnosis is two years.<ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709 }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912 }} </ref><ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref> | The [[disease]] is [[asymptomatic]] in 10% of patients. The average time interval from the onset of [[Symptom|symptoms]] to [[diagnosis]] is two years.<ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709 }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912 }} </ref><ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref>[[Symptom|Symptoms]] of extramammary Paget's disease include the following:<ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref><ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709 }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912 }} </ref> | ||
Symptoms of extramammary Paget's disease include the following:<ref name="ZolloZeitouni2000">{{cite journal|last1=Zollo|first1=J.D.|last2=Zeitouni|first2=N.C.|title=The Roswell Park Cancer Institute experience with extramammary Paget’s disease|journal=British Journal of Dermatology|volume=142|issue=1|year=2000|pages=59–65|issn=00070963|doi=10.1046/j.1365-2133.2000.03242.x}}</ref><ref name="pmid10739709">{{cite journal| author=Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J et al.| title=Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. | journal=Gynecol Oncol | year= 2000 | volume= 77 | issue= 1 | pages= 183-9 | pmid=10739709 | doi=10.1006/gyno.2000.5741 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10739709 }} </ref><ref name="pmid12193912">{{cite journal| author=Tebes S, Cardosi R, Hoffman M| title=Paget's disease of the vulva. | journal=Am J Obstet Gynecol | year= 2002 | volume= 187 | issue= 2 | pages= 281-3; discussion 283-4 | pmid=12193912 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12193912 }} </ref> | |||
*Pruritis | *Pruritis | ||
**[[Pruritus]] is the most common symptom, occurring in around approximately 70% of patients | **[[Pruritus]] is the most common [[symptom]], occurring in around approximately 70% of [[Patient|patients]] | ||
*Vulvar pain | *[[Vulva|Vulvar]] pain | ||
*Vulvar bleeding | *[[Vulva|Vulvar]] bleeding | ||
*Burning sensation | *Burning sensation | ||
Revision as of 13:22, 10 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Symptoms of extramammary Paget's disease include pruritus, vulvar pain, vulvar bleeding, and burning sensation.[1][2][3]
History
In any patient with chronic dermatitis of the vulva, groin, or perianal are, the possibility of extramammary Paget disease (EMPD) should be carefully considered. Patients with EMPD usually present with nonresolving eczematous lesions in the genitalia, groin, perineum, or perianal area.[4]
Symptoms
The disease is asymptomatic in 10% of patients. The average time interval from the onset of symptoms to diagnosis is two years.[2][3][1]Symptoms of extramammary Paget's disease include the following:[1][2][3]
References
- ↑ 1.0 1.1 1.2 Zollo, J.D.; Zeitouni, N.C. (2000). "The Roswell Park Cancer Institute experience with extramammary Paget's disease". British Journal of Dermatology. 142 (1): 59–65. doi:10.1046/j.1365-2133.2000.03242.x. ISSN 0007-0963.
- ↑ 2.0 2.1 2.2 Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J; et al. (2000). "Paget's disease of the vulva: pathology, pattern of involvement, and prognosis". Gynecol Oncol. 77 (1): 183–9. doi:10.1006/gyno.2000.5741. PMID 10739709.
- ↑ 3.0 3.1 3.2 Tebes S, Cardosi R, Hoffman M (2002). "Paget's disease of the vulva". Am J Obstet Gynecol. 187 (2): 281–3, discussion 283-4. PMID 12193912.
- ↑ Bagby CM, MacLennan GT (2009). "Extramammary Paget's disease of the penis and scrotum". J Urol. 182 (6): 2908–9. doi:10.1016/j.juro.2009.09.027. PMID 19846157.