Neurofibroma surgery: Difference between revisions
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{{CMG}}; {{AE}}{{S.M.}} {{SC}} | {{CMG}}; {{AE}}{{S.M.}} {{SC}} | ||
==Overview== | ==Overview== | ||
[[Surgery]] is the mainstay of treatment for neurofibroma. | [[Surgery]] is the mainstay of treatment for neurofibroma. Localized and diffuse lesions usually be treated surgically. Neurofibromas that infiltrate between [[nerve]] fascicles are unable to be separated from the parent nerve, therefore, deep-seated lesions are often managed conservatively. Local recurrence after excision is uncommon .and [[malignant transformation]] is rare | ||
==Surgery== | ==Surgery== | ||
'''Localised neurofibroma and Diffuse neurofibroma (not associated with NF-1)''' | '''Localised neurofibroma and Diffuse neurofibroma (not associated with NF-1)''' | ||
* | * Localized and diffuse lesions usually be treated surgically.<ref name="radio">Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015 </ref> | ||
* Neurofibromas that infiltrate between [[nerve]] fascicles are unable to be separated from the parent nerve, therefore, deep-seated lesions are often managed conservatively | * Neurofibromas that infiltrate between [[nerve]] fascicles are unable to be separated from the parent [[nerve]], therefore, deep-seated lesions are often managed conservatively. | ||
* Local recurrence after excision is uncommon and [[malignant transformation]] is rare | * Local recurrence after excision is uncommon and [[malignant transformation]] is rare. | ||
'''Plexiform neurofibroma (NF-1 associated)''' | '''Plexiform neurofibroma (NF-1 associated)''' | ||
* The primary treatment option for [[plexiform neurofibroma]] is not [[surgery|surgery,]]<ref>{{cite journal |vauthors=Packer RJ, Gutmann DH, Rubenstein A, etal |title=Plexiform neurofibromas in NF1: toward biologic-based therapy |journal=Neurology |volume=58 |issue=10 |pages=1461–70 |date=May 2002 |pmid=12041525 |url=http://www.neurology.org/cgi/pmidlookup?view=long&pmid=12041525 |doi=10.1212/wnl.58.10.1461}}</ref><ref name="radio" /> | * The primary treatment option for [[plexiform neurofibroma]] is not [[surgery|surgery,]] until and unless debilitating symptoms are present and if there is a possibility of malignant transformation.<ref>{{cite journal |vauthors=Packer RJ, Gutmann DH, Rubenstein A, etal |title=Plexiform neurofibromas in NF1: toward biologic-based therapy |journal=Neurology |volume=58 |issue=10 |pages=1461–70 |date=May 2002 |pmid=12041525 |url=http://www.neurology.org/cgi/pmidlookup?view=long&pmid=12041525 |doi=10.1212/wnl.58.10.1461}}</ref><ref name="radio" /> | ||
* Removal of [[plexiform neurofibroma]]s is difficult because they can be large and cross [[tissue]] boundaries hence, leading to incomplete resection | * Removal of [[plexiform neurofibroma]]s is difficult because they can be large and cross [[tissue]] boundaries hence, leading to incomplete resection. | ||
* Recurrence after resection is frequent | * Recurrence after resection is frequent. | ||
==References== | ==References== | ||
Revision as of 20:31, 17 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]
Overview
Surgery is the mainstay of treatment for neurofibroma. Localized and diffuse lesions usually be treated surgically. Neurofibromas that infiltrate between nerve fascicles are unable to be separated from the parent nerve, therefore, deep-seated lesions are often managed conservatively. Local recurrence after excision is uncommon .and malignant transformation is rare
Surgery
Localised neurofibroma and Diffuse neurofibroma (not associated with NF-1)
- Localized and diffuse lesions usually be treated surgically.[1]
- Neurofibromas that infiltrate between nerve fascicles are unable to be separated from the parent nerve, therefore, deep-seated lesions are often managed conservatively.
- Local recurrence after excision is uncommon and malignant transformation is rare.
Plexiform neurofibroma (NF-1 associated)
- The primary treatment option for plexiform neurofibroma is not surgery, until and unless debilitating symptoms are present and if there is a possibility of malignant transformation.[2][1]
- Removal of plexiform neurofibromas is difficult because they can be large and cross tissue boundaries hence, leading to incomplete resection.
- Recurrence after resection is frequent.
References
- ↑ 1.0 1.1 Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015
- ↑ Packer RJ, Gutmann DH, Rubenstein A, et al. (May 2002). "Plexiform neurofibromas in NF1: toward biologic-based therapy". Neurology. 58 (10): 1461–70. doi:10.1212/wnl.58.10.1461. PMID 12041525.