Friedreich's ataxia epidemiology and demographics: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 6: | Line 6: | ||
==Epidemiology and demographics== | ==Epidemiology and demographics== | ||
=== Incidence === | === Incidence === | ||
* The incidence of Friedreich’s ataxia is approximately 2-4 per 100,000 individuals worldwide. | * The incidence of Friedreich’s ataxia is approximately 2-4 per 100,000 individuals worldwide.<ref name="pmid20301458">{{cite journal |vauthors=Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, Bidichandani SI, Delatycki MB |title= |journal= |volume= |issue= |pages= |date= |pmid=20301458 |doi= |url=}}</ref> | ||
=== Prevalence === | === Prevalence === | ||
* The prevalence of Friedreich’s ataxia is approximately 2-4 per 100,000 individuals worldwide. | * The prevalence of Friedreich’s ataxia is approximately 2-4 per 100,000 individuals worldwide.<ref name="pmid20301458">{{cite journal |vauthors=Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, Bidichandani SI, Delatycki MB |title= |journal= |volume= |issue= |pages= |date= |pmid=20301458 |doi= |url=}}</ref> | ||
=== Age === | === Age === | ||
* Friedreich’s Ataxia commonly affects individuals from early childhood through to early adulthood, starting with poor balance when walking, followed by slurred speech and upper-limb ataxia. | * Friedreich’s Ataxia commonly affects individuals from early childhood through to early adulthood, starting with poor balance when walking, followed by slurred speech and upper-limb ataxia.<ref name="pmid20301458">{{cite journal |vauthors=Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, Bidichandani SI, Delatycki MB |title= |journal= |volume= |issue= |pages= |date= |pmid=20301458 |doi= |url=}}</ref> | ||
* Friedreich’s Ataxia is usually first diagnosed at age 10 to 15 years but onset of disease may be as early as age 2 years and as late as the 8th decade. | * Friedreich’s Ataxia is usually first diagnosed at age 10 to 15 years but onset of disease may be as early as age 2 years and as late as the 8th decade.<ref name="pmid20301458">{{cite journal |vauthors=Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, Bidichandani SI, Delatycki MB |title= |journal= |volume= |issue= |pages= |date= |pmid=20301458 |doi= |url=}}</ref> | ||
=== Race and Region === | === Race and Region === | ||
*The GAA triplet repeat expansion that causes Friedreich’s Ataxia usually affects only individuals of the European, North African, Middle Eastern, or Indian origin (Indo-European and Afro-Asiatic speakers). | *The GAA triplet repeat expansion that causes Friedreich’s Ataxia usually affects only individuals of the European, North African, Middle Eastern, or Indian origin (Indo-European and Afro-Asiatic speakers).<ref name="pmid1376805">{{cite journal |vauthors=Grichois ML, Blanc J, Deckert V, Elghozi JL |title=Differential effects of enalapril and hydralazine on short-term variability of blood pressure and heart rate in rats |journal=J. Cardiovasc. Pharmacol. |volume=19 |issue=6 |pages=863–9 |date=June 1992 |pmid=1376805 |doi= |url=}}</ref> | ||
*Sub-Saharan Africans, Amerindians, and individuals from China, Japan, and Southeast Asia are less likely to develop Friedreich’s Ataxia. | *Sub-Saharan Africans, Amerindians, and individuals from China, Japan, and Southeast Asia are less likely to develop Friedreich’s Ataxia.<ref name="pmid4768799">{{cite journal |vauthors=Escudero E, Moreyra A, Iveli C, Lardani H, Cingolani HE |title=[Myocardial contractility: an experimental analysis of various proposed indices] |language=Spanish; Castilian |journal=Acta Physiol Lat Am |volume=23 |issue=4 |pages=250–69 |date=April 1973 |pmid=4768799 |doi= |url=}}</ref> | ||
=== Gender === | === Gender === | ||
* Friedreich’s Ataxia affects men and women equally. | * Friedreich’s Ataxia affects men and women equally. | ||
* Female are more commonly affected by clinical fractures than male. | * Female are more commonly affected by clinical fractures than male.<ref name="pmid20301458">{{cite journal |vauthors=Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, Bidichandani SI, Delatycki MB |title= |journal= |volume= |issue= |pages= |date= |pmid=20301458 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 17:00, 19 April 2019
|
Friedreich's ataxia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Friedreich's ataxia epidemiology and demographics On the Web |
|
American Roentgen Ray Society Images of Friedreich's ataxia epidemiology and demographics |
|
Friedreich's ataxia epidemiology and demographics in the news |
|
Risk calculators and risk factors for Friedreich's ataxia epidemiology and demographics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[[2]]
Overview
Epidemiology and demographics
Incidence
- The incidence of Friedreich’s ataxia is approximately 2-4 per 100,000 individuals worldwide.[1]
Prevalence
- The prevalence of Friedreich’s ataxia is approximately 2-4 per 100,000 individuals worldwide.[1]
Age
- Friedreich’s Ataxia commonly affects individuals from early childhood through to early adulthood, starting with poor balance when walking, followed by slurred speech and upper-limb ataxia.[1]
- Friedreich’s Ataxia is usually first diagnosed at age 10 to 15 years but onset of disease may be as early as age 2 years and as late as the 8th decade.[1]
Race and Region
- The GAA triplet repeat expansion that causes Friedreich’s Ataxia usually affects only individuals of the European, North African, Middle Eastern, or Indian origin (Indo-European and Afro-Asiatic speakers).[2]
- Sub-Saharan Africans, Amerindians, and individuals from China, Japan, and Southeast Asia are less likely to develop Friedreich’s Ataxia.[3]
Gender
- Friedreich’s Ataxia affects men and women equally.
- Female are more commonly affected by clinical fractures than male.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean L, Stephens K, Amemiya A, Bidichandani SI, Delatycki MB. PMID 20301458. Vancouver style error: initials (help); Missing or empty
|title=(help) - ↑ Grichois ML, Blanc J, Deckert V, Elghozi JL (June 1992). "Differential effects of enalapril and hydralazine on short-term variability of blood pressure and heart rate in rats". J. Cardiovasc. Pharmacol. 19 (6): 863–9. PMID 1376805.
- ↑ Escudero E, Moreyra A, Iveli C, Lardani H, Cingolani HE (April 1973). "[Myocardial contractility: an experimental analysis of various proposed indices]". Acta Physiol Lat Am (in Spanish; Castilian). 23 (4): 250–69. PMID 4768799.