Friedreich's ataxia natural history, complications and prognosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
Line 9: | Line 9: | ||
=== Complications === | === Complications === | ||
* Common complications of Friedreich’s Ataxia include: | * Common complications of Friedreich’s Ataxia include: | ||
** [[Aspiration pneumonia]] | ** [[Aspiration pneumonia]]<ref name="pmid28803513">{{cite journal |vauthors=Byard RW, Gilbert JD |title=Mechanisms of unexpected death and autopsy findings in Friedreich ataxia |journal=Med Sci Law |volume=57 |issue=4 |pages=192–196 |date=October 2017 |pmid=28803513 |doi=10.1177/0025802417723809 |url=}}</ref> | ||
** [[Hypertrophic cardiomyopathy]] | ** [[Hypertrophic cardiomyopathy]]<ref name="pmid23859344">{{cite journal |vauthors=Weidemann F, Störk S, Liu D, Hu K, Herrmann S, Ertl G, Niemann M |title=Cardiomyopathy of Friedreich ataxia |journal=J. Neurochem. |volume=126 Suppl 1 |issue= |pages=88–93 |date=August 2013 |pmid=23859344 |doi=10.1111/jnc.12217 |url=}}</ref> | ||
** [[Diabetic coma]] | ** [[Diabetic coma]]<ref name="pmid6224121">{{cite journal |vauthors=Körner A, Barta L |title=[Association of diabetes mellitus with Friedreich's ataxia] |language=Hungarian |journal=Orv Hetil |volume=124 |issue=23 |pages=1391–2 |date=June 1983 |pmid=6224121 |doi= |url=}}</ref> | ||
** [[Embolic stroke]] | ** [[Embolic stroke]]<ref name="pmid3062632">{{cite journal |vauthors=Marcus AJ, Safier LB, Ullman HL, Islam N, Broekman MJ, Falck JR, Fischer S, von Schacky C |title=Cell-cell interactions in the eicosanoid pathways |journal=Prog. Clin. Biol. Res. |volume=283 |issue= |pages=559–67 |date=1988 |pmid=3062632 |doi= |url=}}</ref> | ||
** [[Cerebral haemorrhage]] | ** [[Cerebral haemorrhage]]<ref name="pmid28803513">{{cite journal |vauthors=Byard RW, Gilbert JD |title=Mechanisms of unexpected death and autopsy findings in Friedreich ataxia |journal=Med Sci Law |volume=57 |issue=4 |pages=192–196 |date=October 2017 |pmid=28803513 |doi=10.1177/0025802417723809 |url=}}</ref> | ||
** [[Trauma]] sequelae | ** [[Trauma]] sequelae<ref name="pmid13501109">{{cite journal |vauthors=FRIEDMAN JH, ARENGO A |title=Friedreich's ataxia ascribed to trauma; case report |journal=Dis Nerv Syst |volume=19 |issue=1 |pages=35–6 |date=January 1958 |pmid=13501109 |doi= |url=}}</ref><ref name="pmid8155012">{{cite journal |vauthors=Junck L, Gilman S, Gebarski SS, Koeppe RA, Kluin KJ, Markel DS |title=Structural and functional brain imaging in Friedreich's ataxia |journal=Arch. Neurol. |volume=51 |issue=4 |pages=349–55 |date=April 1994 |pmid=8155012 |doi= |url=}}</ref> | ||
** [[Renal failure]] | ** [[Renal failure]]<ref name="pmid3062632">{{cite journal |vauthors=Marcus AJ, Safier LB, Ullman HL, Islam N, Broekman MJ, Falck JR, Fischer S, von Schacky C |title=Cell-cell interactions in the eicosanoid pathways |journal=Prog. Clin. Biol. Res. |volume=283 |issue= |pages=559–67 |date=1988 |pmid=3062632 |doi= |url=}}</ref> | ||
*The presence of [[diabetes]] and [[dilated cardiomyopathy]] has a negative impact on survival of patients with Friedreich’s Ataxia. | *The presence of [[diabetes]] and [[dilated cardiomyopathy]] has a negative impact on survival of patients with Friedreich’s Ataxia.<ref name="pmid3062632">{{cite journal |vauthors=Marcus AJ, Safier LB, Ullman HL, Islam N, Broekman MJ, Falck JR, Fischer S, von Schacky C |title=Cell-cell interactions in the eicosanoid pathways |journal=Prog. Clin. Biol. Res. |volume=283 |issue= |pages=559–67 |date=1988 |pmid=3062632 |doi= |url=}}</ref> | ||
=== Prognosis === | === Prognosis === |
Revision as of 16:39, 22 April 2019
Friedreich's ataxia Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Friedreich's ataxia natural history, complications and prognosis On the Web |
American Roentgen Ray Society Images of Friedreich's ataxia natural history, complications and prognosis |
FDA on Friedreich's ataxia natural history, complications and prognosis |
CDC on Friedreich's ataxia natural history, complications and prognosis |
Friedreich's ataxia natural history, complications and prognosis in the news |
Blogs on Friedreich's ataxia natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[[2]]
Overview
Natural History
- The symptoms of Friedreich’s Ataxia usually develop in the second decade of life but onset of disease may be as early as age 2 years and as late as the 8th decade, and start with progressive ataxiae.
Complications
- Common complications of Friedreich’s Ataxia include:
- The presence of diabetes and dilated cardiomyopathy has a negative impact on survival of patients with Friedreich’s Ataxia.[4]
Prognosis
- The average age of death of patients with Friedreich’s Ataxia is at 37.5 years.
- Depending on the extent of the disease progression at the time of diagnosis, the prognosis may vary.
- The presence of hypertrophic cardiomyopathy is associated with a particularly poor prognosis among patients with Friedreich’s Ataxia.
References
- ↑ 1.0 1.1 Byard RW, Gilbert JD (October 2017). "Mechanisms of unexpected death and autopsy findings in Friedreich ataxia". Med Sci Law. 57 (4): 192–196. doi:10.1177/0025802417723809. PMID 28803513.
- ↑ Weidemann F, Störk S, Liu D, Hu K, Herrmann S, Ertl G, Niemann M (August 2013). "Cardiomyopathy of Friedreich ataxia". J. Neurochem. 126 Suppl 1: 88–93. doi:10.1111/jnc.12217. PMID 23859344.
- ↑ Körner A, Barta L (June 1983). "[Association of diabetes mellitus with Friedreich's ataxia]". Orv Hetil (in Hungarian). 124 (23): 1391–2. PMID 6224121.
- ↑ 4.0 4.1 4.2 Marcus AJ, Safier LB, Ullman HL, Islam N, Broekman MJ, Falck JR, Fischer S, von Schacky C (1988). "Cell-cell interactions in the eicosanoid pathways". Prog. Clin. Biol. Res. 283: 559–67. PMID 3062632.
- ↑ FRIEDMAN JH, ARENGO A (January 1958). "Friedreich's ataxia ascribed to trauma; case report". Dis Nerv Syst. 19 (1): 35–6. PMID 13501109.
- ↑ Junck L, Gilman S, Gebarski SS, Koeppe RA, Kluin KJ, Markel DS (April 1994). "Structural and functional brain imaging in Friedreich's ataxia". Arch. Neurol. 51 (4): 349–55. PMID 8155012.