Neurofibroma laboratory findings: Difference between revisions
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{{CMG}}; {{AE}}{{S.M.}} | {{CMG}}; {{AE}}{{S.M.}} | ||
==Overview== | ==Overview== | ||
[[Immunohistochemistry]] | On [[Immunohistochemistry]], [[neurofibroma]] stains positive for [[S100A1|S100]], SOX10, [[CD34]], factor XIIIa, [[Neurofilament]] (and Bielshowsky), [[GFAP]] and [[Calretinin]] and negative for EMA, [[Keratin]], smooth muscle actin, [[Desmin]], [[Calponin]], [[Caldesmon]] and [[P53]]. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
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*Positive for: | *Positive for: | ||
**[[S100A1|S100]] | **[[S100A1|S100]] | ||
** | **SOX10 | ||
**[[CD34]] (focal) | **[[CD34]] (focal) | ||
**Factor XIIIa (focal) | **Factor XIIIa (focal) | ||
Revision as of 01:16, 25 April 2019
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Neurofibroma Microchapters |
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Neurofibroma laboratory findings On the Web |
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American Roentgen Ray Society Images of Neurofibroma laboratory findings |
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Risk calculators and risk factors for Neurofibroma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
On Immunohistochemistry, neurofibroma stains positive for S100, SOX10, CD34, factor XIIIa, Neurofilament (and Bielshowsky), GFAP and Calretinin and negative for EMA, Keratin, smooth muscle actin, Desmin, Calponin, Caldesmon and P53.
Laboratory Findings
Immunohistochemistry of neurofibroma is as follows:
- Positive for:
- S100
- SOX10
- CD34 (focal)
- Factor XIIIa (focal)
- Neurofilament (and Bielshowsky)
- GFAP
- Calretinin (focal)
- Negative for:
| Immunohistochemical stain | Neurofibroma | Schwannoma |
|---|---|---|
| S-100 and SOX10 | Moderate positivity | Strong, diffuse positivity |
| CD34 | Moderate | Scattered cells in Antoni B areas |
| Neurofilament (and Bielshowsky) | Stains entrapped axons within lesion | Stains peripherally located axons of parent nerve |
| Factor XIIIa | Moderate | Negative to focal |
| Calretinin | Negative to focal | Moderate |
| GFAP | Variable, weak | Variable, moderate |