Friedreich's ataxia electrocardiogram: Difference between revisions
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==Electrocardiogram== | ==Electrocardiogram== | ||
An ECG may be helpful in the diagnosis of Friedreich's ataxia. Findings on an ECG suggestive of Friedreich's ataxia include:<ref name="pmid30705738">{{cite journal |vauthors=Hanson E, Sheldon M, Pacheco B, Alkubeysi M, Raizada V |title=Heart disease in Friedreich's ataxia |journal=World J Cardiol |volume=11 |issue=1 |pages=1–12 |date=January 2019 |pmid=30705738 |pmc=6354072 |doi=10.4330/wjc.v11.i1.1 |url=}}</ref><ref name="pmid22764179">{{cite journal |vauthors=Payne RM, Wagner GR |title=Cardiomyopathy in Friedreich ataxia: clinical findings and research |journal=J. Child Neurol. |volume=27 |issue=9 |pages=1179–86 |date=September 2012 |pmid=22764179 |pmc=3674565 |doi=10.1177/0883073812448535 |url=}}</ref><ref name="pmid26414159">{{cite journal |vauthors=Pousset F, Legrand L, Monin ML, Ewenczyk C, Charles P, Komajda M, Brice A, Pandolfo M, Isnard R, Tezenas du Montcel S, Durr A |title=A 22-Year Follow-up Study of Long-term Cardiac Outcome and Predictors of Survival in Friedreich Ataxia |journal=JAMA Neurol |volume=72 |issue=11 |pages=1334–41 |date=November 2015 |pmid=26414159 |doi=10.1001/jamaneurol.2015.1855 |url=}}</ref><ref name="pmid22373590">{{cite journal |vauthors=Payne RM, Peverill RE |title=Cardiomyopathy of Friedreich's ataxia (FRDA) |journal=Ir J Med Sci |volume=181 |issue=4 |pages=569–70 |date=December 2012 |pmid=22373590 |doi=10.1007/s11845-012-0808-7 |url=}}</ref><ref name="pmid23859344">{{cite journal |vauthors=Weidemann F, Störk S, Liu D, Hu K, Herrmann S, Ertl G, Niemann M |title=Cardiomyopathy of Friedreich ataxia |journal=J. Neurochem. |volume=126 Suppl 1 |issue= |pages=88–93 |date=August 2013 |pmid=23859344 |doi=10.1111/jnc.12217 |url=}}</ref> | An ECG may be helpful in the diagnosis of Friedreich's ataxia. Findings on an ECG suggestive of Friedreich's ataxia include:<ref name="pmid30705738">{{cite journal |vauthors=Hanson E, Sheldon M, Pacheco B, Alkubeysi M, Raizada V |title=Heart disease in Friedreich's ataxia |journal=World J Cardiol |volume=11 |issue=1 |pages=1–12 |date=January 2019 |pmid=30705738 |pmc=6354072 |doi=10.4330/wjc.v11.i1.1 |url=}}</ref><ref name="pmid22764179">{{cite journal |vauthors=Payne RM, Wagner GR |title=Cardiomyopathy in Friedreich ataxia: clinical findings and research |journal=J. Child Neurol. |volume=27 |issue=9 |pages=1179–86 |date=September 2012 |pmid=22764179 |pmc=3674565 |doi=10.1177/0883073812448535 |url=}}</ref><ref name="pmid26414159">{{cite journal |vauthors=Pousset F, Legrand L, Monin ML, Ewenczyk C, Charles P, Komajda M, Brice A, Pandolfo M, Isnard R, Tezenas du Montcel S, Durr A |title=A 22-Year Follow-up Study of Long-term Cardiac Outcome and Predictors of Survival in Friedreich Ataxia |journal=JAMA Neurol |volume=72 |issue=11 |pages=1334–41 |date=November 2015 |pmid=26414159 |doi=10.1001/jamaneurol.2015.1855 |url=}}</ref><ref name="pmid22373590">{{cite journal |vauthors=Payne RM, Peverill RE |title=Cardiomyopathy of Friedreich's ataxia (FRDA) |journal=Ir J Med Sci |volume=181 |issue=4 |pages=569–70 |date=December 2012 |pmid=22373590 |doi=10.1007/s11845-012-0808-7 |url=}}</ref><ref name="pmid23859344">{{cite journal |vauthors=Weidemann F, Störk S, Liu D, Hu K, Herrmann S, Ertl G, Niemann M |title=Cardiomyopathy of Friedreich ataxia |journal=J. Neurochem. |volume=126 Suppl 1 |issue= |pages=88–93 |date=August 2013 |pmid=23859344 |doi=10.1111/jnc.12217 |url=}}</ref><ref name="pmid22752487">{{cite journal |vauthors=Schadt KA, Friedman LS, Regner SR, Mark GE, Lynch DR, Lin KY |title=Cross-sectional analysis of electrocardiograms in a large heterogeneous cohort of Friedreich ataxia subjects |journal=J. Child Neurol. |volume=27 |issue=9 |pages=1187–92 |date=September 2012 |pmid=22752487 |pmc=3674639 |doi=10.1177/0883073812448461 |url=}}</ref> | ||
*[[T-wave]] [[repolarization]] abnormalities, especially in the inferior and lateral leads, is the most common abnormalities seen on the electrocardiogram (ECG) of patients with Friedreich's ataxia(approximately 85%). | *[[T-wave]] [[repolarization]] abnormalities, especially in the inferior and lateral leads, is the most common abnormalities seen on the electrocardiogram (ECG) of patients with Friedreich's ataxia(approximately 85%). | ||
*[[Bundle branch block]]s is found in 15% of patients with Friedreich's ataxia | *[[Bundle branch block]]s is found in 15% of patients with Friedreich's ataxia | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: MMJ
Overview
Electrocardiogram
An ECG may be helpful in the diagnosis of Friedreich's ataxia. Findings on an ECG suggestive of Friedreich's ataxia include:[1][2][3][4][5][6]
- T-wave repolarization abnormalities, especially in the inferior and lateral leads, is the most common abnormalities seen on the electrocardiogram (ECG) of patients with Friedreich's ataxia(approximately 85%).
- Bundle branch blocks is found in 15% of patients with Friedreich's ataxia
- Ventricular hypertrophy, or right axis deviation
- Short PR interval in up to 24% of patients
- Interatrial block in up to 48% of patients
- Left atrial enlargement
- Right atrial enlargement
References
- ↑ Hanson E, Sheldon M, Pacheco B, Alkubeysi M, Raizada V (January 2019). "Heart disease in Friedreich's ataxia". World J Cardiol. 11 (1): 1–12. doi:10.4330/wjc.v11.i1.1. PMC 6354072. PMID 30705738.
- ↑ Payne RM, Wagner GR (September 2012). "Cardiomyopathy in Friedreich ataxia: clinical findings and research". J. Child Neurol. 27 (9): 1179–86. doi:10.1177/0883073812448535. PMC 3674565. PMID 22764179.
- ↑ Pousset F, Legrand L, Monin ML, Ewenczyk C, Charles P, Komajda M, Brice A, Pandolfo M, Isnard R, Tezenas du Montcel S, Durr A (November 2015). "A 22-Year Follow-up Study of Long-term Cardiac Outcome and Predictors of Survival in Friedreich Ataxia". JAMA Neurol. 72 (11): 1334–41. doi:10.1001/jamaneurol.2015.1855. PMID 26414159.
- ↑ Payne RM, Peverill RE (December 2012). "Cardiomyopathy of Friedreich's ataxia (FRDA)". Ir J Med Sci. 181 (4): 569–70. doi:10.1007/s11845-012-0808-7. PMID 22373590.
- ↑ Weidemann F, Störk S, Liu D, Hu K, Herrmann S, Ertl G, Niemann M (August 2013). "Cardiomyopathy of Friedreich ataxia". J. Neurochem. 126 Suppl 1: 88–93. doi:10.1111/jnc.12217. PMID 23859344.
- ↑ Schadt KA, Friedman LS, Regner SR, Mark GE, Lynch DR, Lin KY (September 2012). "Cross-sectional analysis of electrocardiograms in a large heterogeneous cohort of Friedreich ataxia subjects". J. Child Neurol. 27 (9): 1187–92. doi:10.1177/0883073812448461. PMC 3674639. PMID 22752487.