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* Karzinoide or “[[carcinoma]]-like” describes the unique feature of behaving like a [[benign]] [[tumor]] despite resembling a [[carcinoma]] microscopically. | * Karzinoide or “[[carcinoma]]-like” describes the unique feature of behaving like a [[benign]] [[tumor]] despite resembling a [[carcinoma]] microscopically. | ||
* Rapport and colleagues isolated and named [[serotonin]] [[5-HT|(5-HT]]), initially identified as a [[vasoconstrictor]] [[substance]] in the [[serum]].<ref name="pmid18100415">{{cite journal |vauthors=RAPPORT MM, GREEN AA, PAGE IH |title=Serum vasoconstrictor, serotonin; isolation and characterization |journal=J. Biol. Chem. |volume=176 |issue=3 |pages=1243–51 |date=December 1948 |pmid=18100415 |doi= |url=}}</ref> | * Rapport and colleagues isolated and named [[serotonin]] [[5-HT|(5-HT]]), initially identified as a [[vasoconstrictor]] [[substance]] in the [[serum]].<ref name="pmid18100415">{{cite journal |vauthors=RAPPORT MM, GREEN AA, PAGE IH |title=Serum vasoconstrictor, serotonin; isolation and characterization |journal=J. Biol. Chem. |volume=176 |issue=3 |pages=1243–51 |date=December 1948 |pmid=18100415 |doi= |url=}}</ref> | ||
* [[Enterochromaffin]] [[Cell|cel]]<nowiki/>l,the [[cell]] of origin of [[carcinoid tumour]] had been identified as early as 1897 by N. Kulchitsky (1856-1925). | *<nowiki/>[[Enterochromaffin]] [[Cell|cel]]<nowiki/>l,the [[cell]] of origin of [[carcinoid tumour]] had been identified as early as 1897 by N. Kulchitsky (1856-1925). | ||
* F. Lembeck | * In 1953, F. Lembeck <nowiki/>established that [[enterochromaffin]] [[cells]] synthesizes and secretes [[serotonin]], the major [[hormone]] responsible for [[Carcinoid Syndrome|carcinoid syndrome.]]<ref name="pmid14941051">{{cite journal |vauthors=ERSPAMER V, ASERO B |title=Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine |journal=Nature |volume=169 |issue=4306 |pages=800–1 |date=May 1952 |pmid=14941051 |doi= |url=}}</ref><ref name="pmid16882492">{{cite journal |vauthors=Sippel RS, Chen H |title=Carcinoid tumors |journal=Surg. Oncol. Clin. N. Am. |volume=15 |issue=3 |pages=463–78 |date=July 2006 |pmid=16882492 |doi=10.1016/j.soc.2006.05.002 |url=}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 20:55, 30 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
The term Carcinoid was given by Siegfried Oberndorfer, a German pathologist at the University of Munich in 1907. Enterochromaffin cell, the cell of origin of carcinoid tumour had been identified as early as 1897 by N. Kulchitsky.
Historical Perspective
- Theodor Langhans (1839–1915) was the first to describe the histology of a carcinoid tumor in 1867.
- The term Carcinoid was given by Siegfried Oberndorfer, a German pathologist at the University of Munich in 1907.
- Siegfried Oberndorfer referred the carcinoid tumor as "benign carcinomas" as they had distinct clinical entities and named them "karzinoide"(carcinoma-like).
- Karzinoide or “carcinoma-like” describes the unique feature of behaving like a benign tumor despite resembling a carcinoma microscopically.
- Rapport and colleagues isolated and named serotonin (5-HT), initially identified as a vasoconstrictor substance in the serum.[1]
- Enterochromaffin cell,the cell of origin of carcinoid tumour had been identified as early as 1897 by N. Kulchitsky (1856-1925).
- In 1953, F. Lembeck established that enterochromaffin cells synthesizes and secretes serotonin, the major hormone responsible for carcinoid syndrome.[2][3]
References
- ↑ RAPPORT MM, GREEN AA, PAGE IH (December 1948). "Serum vasoconstrictor, serotonin; isolation and characterization". J. Biol. Chem. 176 (3): 1243–51. PMID 18100415.
- ↑ ERSPAMER V, ASERO B (May 1952). "Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine". Nature. 169 (4306): 800–1. PMID 14941051.
- ↑ Sippel RS, Chen H (July 2006). "Carcinoid tumors". Surg. Oncol. Clin. N. Am. 15 (3): 463–78. doi:10.1016/j.soc.2006.05.002. PMID 16882492.