Retinoblastoma medical therapy: Difference between revisions
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===Management options of Retinoblastoma=== | |||
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! colspan="2" |Treatment options for Intraocular tumor<ref name="urlRetinoblastoma Treatment (PDQ®)—Health Professional Version - National Cancer Institute">{{cite web |url=https://www.cancer.gov/types/retinoblastoma/hp/retinoblastoma-treatment-pdq#_13 |title=Retinoblastoma Treatment (PDQ®)—Health Professional Version - National Cancer Institute |format= |work= |accessdate=}}</ref> | |||
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|Unilateral retinoblastoma | |||
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* Enucleation followed by chemotherapy | |||
*Conservative ocular salvage approaches: | |||
**Chemoreduction with either systemic or ophthalmic artery infusion chemotherapy with or without intravitreal chemotherapy | |||
**Local treatments (cryotherapy, thermotherapy, and plaque radiation therapy) | |||
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|Bilateral retinoblastoma | |||
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* Enucleation for large intraocular tumors, followed by risk-adapted chemotherapy when the eye and vision cannot be saved | |||
* Conservative ocular salvage approaches when the eye and vision can be saved: | |||
**Chemoreduction with either systemic or ophthalmic artery infusion chemotherapy with or without intravitreal chemotherapy | |||
**Local treatments (cryotherapy, thermotherapy, and plaque radiation therapy) | |||
**EBRT | |||
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|Cavitary retinoblastoma | |||
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* Systemic and/or intra-arterial chemotherapy | |||
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|Progressive or recurrent intraocular retinoblastoma | |||
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* Enucleation | |||
* Radiation therapy (EBRT or plaque radiation therapy) | |||
* Local treatments (cryotherapy or thermotherapy) | |||
* Salvage chemotherapy (systemic or intra-arterial) | |||
* Intravitreal chemotherapy | |||
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! colspan="2" |Treatment options for Extraocular tumor<ref name="urlRetinoblastoma Treatment (PDQ®)—Health Professional Version - National Cancer Institute">{{cite web |url=https://www.cancer.gov/types/retinoblastoma/hp/retinoblastoma-treatment-pdq#_13 |title=Retinoblastoma Treatment (PDQ®)—Health Professional Version - National Cancer Institute |format= |work= |accessdate=}}</ref> | |||
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|Orbital and locoregional retinoblastoma | |||
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* Chemotherapy | |||
* Radiation therapy | |||
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|CNS disease | |||
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* Systemic chemotherapy and CNS-directed therapy | |||
* Systemic chemotherapy followed by myeloablative chemotherapy and stem cell rescue | |||
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|Trilateral retinoblastoma | |||
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* Systemic chemotherapy followed by surgery and myeloablative chemotherapy with stem cell rescue | |||
* Systemic chemotherapy followed by surgery and radiation therapy | |||
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|Extracranial metastatic retinoblastoma | |||
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* Systemic chemotherapy followed by myeloablative chemotherapy with stem cell rescue and radiation therapy | |||
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|Progressive or recurrent extraocular retinoblastoma | |||
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* Systemic chemotherapy and radiation therapy for orbital disease | |||
* Systemic chemotherapy followed by myeloablative chemotherapy with stem cell rescue, and radiation therapy for extraorbital disease | |||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 15:36, 3 May 2019
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Retinoblastoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Retinoblastoma medical therapy On the Web |
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American Roentgen Ray Society Images of Retinoblastoma medical therapy |
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Risk calculators and risk factors for Retinoblastoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
The optimal therapy for retinoblastoma depends on several factors such as tumor size, tumor location, presence or absence of vitreous or subretinal seeds, age of the patient age. The various treatment modalities for retinoblastoma include enucleation, external beam radiation therapy, radioactive plaques (I-125 brachytherapy), cryotherapy, laser photocoagulation, thermotherapy, and chemotherapy (which includes systemic, intra-arterial, and intravitreal).[1]
Medical therapy for intraocular tumors
The priority of retinoblastoma treatment is to preserve the life of the child, then to preserve vision, and then to minimize complications or side effects of treatment. The exact course of treatment will depend on the individual case and will be decided by the ophthalmologist in discussion with the paediatric oncologist. Children with involvement of both eyes at diagnosis usually require multimodality therapy (chemotherapy and local therapies).[1] The goals of therapy are the following:[2]
- Eradicate the disease to save the patient's life
- Preserve as much vision as possible
- Decrease risk of late sequelae from treatment, particularly subsequent neoplasms
The choice of therapy depends upon several factors such as:[3]
The various treatment modalities for retinoblastoma include:
Enucleation of the eye
Most patients with unilateral disease present with advanced intraocular disease and therefore usually undergo enucleation, which results in a cure rate of 95%. In bilateral retinoblastoma, enucleation is usually reserved for eyes that have failed all known effective therapies or without useful vision.
External beam radiotherapy (EBR)
The most common indication for EBR is for the eye in a young child with bilateral retinoblastoma who has active or recurrent disease after completion of chemotherapy and local therapies. However, patients with hereditary disease who received EBR therapy are reported to have a 35% increased risk of recurrence.
Brachytherapy
Brachytherapy involves the placement of a radioactive implant (plaque), usually on the sclera adjacent to the base of a tumor. It is used as the primary treatment or, more frequently, in patients with small tumors or in those who had failed initial therapy including previous EBR therapy.
Thermotherapy
Thermotherapy involves the application of heat directly to the tumor, usually in the form of infrared radiation. It is also used for small tumors.
Laser photocoagulation
Laser photocoagulation is recommended only for small posterior tumors. An argon or diode laser or a xenon arc is used to coagulate all the blood supply to the tumor.
Cryotherapy
Cryotherapy induces damage to the vascular endothelium with secondary thrombosis and infarction of the tumor tissue by rapidly freezing it. Cryotherapy may be used as primary therapy for small peripheral tumors or small recurrent tumors previously treated with other methods.
Systemic chemotherapy
Systemic chemotherapy has become forefront of treatment in the past decade, in search of globe preserving measures and to avoid the adverse effects of EBR therapy. The common indications for chemotherapy for intraocular retinoblastoma include:
- Large tumors
- Tumors that cannot be treated with local therapies alone
- Bilateral tumors
- Invasion into the choroid, optic nerve, sclera, orbit, or anterior chamber
Intra-arterial chemotherapy
Chemotherapeutic drugs are administered locally via a thin catheter threaded through the groin, aorta, and the neck directly into the optic vessels.
| Patient Group | Treatment Line | Treatment |
|---|---|---|
| With vitreous seeding | ||
| With gross anterior chamber involvement or neovascular glaucoma or orbital inflammation | First | Enucleation |
| Adjunct | Postoperative systemic chemotherapy | |
| Without gross anterior chamber involvement or neovascular glaucoma or orbital inlammation | First | Systemic or intra-arterial chemotherapy |
| Plus | Concurrent laser ablation or chemotherapy | |
| Second | External beam radiation therapy | |
| Third | Periocular carboplatin therapy | |
| Fourth | Enucleation | |
| Without vitreous seeding | ||
| Tumor >2 disc diameters in size | First | Systemic or intra-arterial chemotherapy |
| Plus | Concurrent laser ablation or cryotherapy | |
| Second | External beam radiation therapy | |
| Third | Periocular carboplatin therapy | |
| Fourth | Enucleation | |
| Tumor 2 disc diameters or less in size | First | Focal laser ablation alone |
| Second | Systemic or intra-arterial chemotherapy | |
| Plus | Concurrent laser ablation or cryotherapy | |
| Third | External beam radiation therapy | |
| Fourth | Periocular carboplatin therapy | |
| Fifth | Enucleation | |
| Metastatic disease | First | Multimodal therapy |
| Recurrence | ||
| Post globe-salvaging therapy | First | Brachytherapy |
| Post enucleation | First | External beam radiation therapy |
| Adjunct | Systemic chemotherapy | |
Management options of Retinoblastoma
| Treatment options for Intraocular tumor[4] | |
|---|---|
| Unilateral retinoblastoma |
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| Bilateral retinoblastoma |
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| Cavitary retinoblastoma |
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| Progressive or recurrent intraocular retinoblastoma |
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| Treatment options for Extraocular tumor[4] | |
| Orbital and locoregional retinoblastoma |
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| CNS disease |
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| Trilateral retinoblastoma |
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| Extracranial metastatic retinoblastoma |
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| Progressive or recurrent extraocular retinoblastoma |
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References
- ↑ 1.0 1.1 Retinoblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Retinoblastoma Accessed on October 10, 2015
- ↑ Retinoblastoma Treatment. National Cancer Institute(2015) http://www.cancer.gov/types/retinoblastoma/hp/retinoblastoma-treatment-pdq#section/_53 Accessed on October 13, 2015
- ↑ Shields CL, Shields JA (1999). "Recent developments in the management of retinoblastoma". J Pediatr Ophthalmol Strabismus. 36 (1): 8–18, quiz 35-6. PMID 9972509.
- ↑ 4.0 4.1 "Retinoblastoma Treatment (PDQ®)—Health Professional Version - National Cancer Institute".