Seminoma laboratory findings: Difference between revisions
Jump to navigation
Jump to search
| Line 6: | Line 6: | ||
Common laboratory tests performed in seminoma include complete blood count and blood chemistry tests. Laboratory findings consistent with the diagnosis of seminoma include abnormal serum tumor marker levels ([[LDH]], [[HCG]]). | Common laboratory tests performed in seminoma include complete blood count and blood chemistry tests. Laboratory findings consistent with the diagnosis of seminoma include abnormal serum tumor marker levels ([[LDH]], [[HCG]]). | ||
Laboratory findings consistent with the diagnosis of seminoma include [[Complete blood count]] ([[Complete blood count|CBC]]), [[white blood cells]], [[Red blood cell|red blood cells]], and [[platelets]]. Kidney function tests is used before and after [[orchiectomy]]. | Laboratory findings consistent with the diagnosis of seminoma include [[Complete blood count]] ([[Complete blood count|CBC]]), [[white blood cells]], [[Red blood cell|red blood cells]], and [[platelets]]. Kidney function tests is used before and after [[orchiectomy]]. [[tumor marker|Serum tumor marker]] tests are generally used to check the response to cancer treatment. The following tumor markers may be measured for testicular seminoma. | ||
[ | |||
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication]. | Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication]. | ||
| Line 27: | Line 23: | ||
===Tumor Marker Tests=== | ===Tumor Marker Tests=== | ||
*[[tumor marker|Serum tumor marker]] tests are generally used to check the response to cancer treatment. | *[[tumor marker|Serum tumor marker]] tests are generally used to check the response to cancer treatment. The following tumor markers may be measured for testicular seminoma. | ||
:*Classical or pure seminoma do not cause an elevated [[AFP|serum alpha fetoprotein]]. | :*Classical or pure seminoma do not cause an elevated [[AFP|serum alpha fetoprotein]]. | ||
:*[[LDH|Lactate dehydrogenase (LDH)]] may be the only marker that is elevated in some seminomas. The degree of elevation in the serum LDH has ''prognostic value'' in advanced seminoma. High LDH levels can indicate that the tumor is large, there is a large amount of cancer in the body, or the cancer is growing quickly. High levels can also mean that a man has advanced seminoma. LDH may also be high with some non-cancerous conditions. | :*[[LDH|Lactate dehydrogenase (LDH)]] may be the only marker that is elevated in some seminomas. The degree of elevation in the serum LDH has ''prognostic value'' in advanced seminoma. High LDH levels can indicate that the tumor is large, there is a large amount of cancer in the body, or the cancer is growing quickly. High levels can also mean that a man has advanced seminoma. LDH may also be high with some non-cancerous conditions. | ||
Revision as of 15:29, 7 May 2019
|
Seminoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Seminoma laboratory findings On the Web |
|
American Roentgen Ray Society Images of Seminoma laboratory findings |
|
Risk calculators and risk factors for Seminoma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Common laboratory tests performed in seminoma include complete blood count and blood chemistry tests. Laboratory findings consistent with the diagnosis of seminoma include abnormal serum tumor marker levels (LDH, HCG).
Laboratory findings consistent with the diagnosis of seminoma include Complete blood count (CBC), white blood cells, red blood cells, and platelets. Kidney function tests is used before and after orchiectomy. Serum tumor marker tests are generally used to check the response to cancer treatment. The following tumor markers may be measured for testicular seminoma.
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
Laboratory Findings
Complete Blood Count
Complete blood count (CBC) measures the number and quality of white blood cells, red blood cells, and platelets.
Blood Chemistry Tests
- Blood chemistry tests that are used to diagnose testicular seminoma include the following:
- Liver function tests:
- High levels of certain substances in the blood may mean that seminoma has spread to the liver.
- Kidney function tests:
- It is used before and after orchiectomy.
- Blood chemistry test are often done in preparation for testicular cancer treatments where they create a baseline, used to compare future levels.
Tumor Marker Tests
- Serum tumor marker tests are generally used to check the response to cancer treatment. The following tumor markers may be measured for testicular seminoma.
- Classical or pure seminoma do not cause an elevated serum alpha fetoprotein.
- Lactate dehydrogenase (LDH) may be the only marker that is elevated in some seminomas. The degree of elevation in the serum LDH has prognostic value in advanced seminoma. High LDH levels can indicate that the tumor is large, there is a large amount of cancer in the body, or the cancer is growing quickly. High levels can also mean that a man has advanced seminoma. LDH may also be high with some non-cancerous conditions.
- Human chorionic gonadotropin (hCG) may be elevated in some cases, but this correlates more to the presence of trophoblast cells within the tumor. HCG can also be high, if the man has liver disease.
- Blood tests may detect the presence of placental alkaline phosphatase (PLAP) in 50% of cases. However, PLAP cannot usefully stand alone as a marker for seminoma and contributes little to follow-up, due to its rise with smoking.