Retinoblastoma history and symptoms: Difference between revisions
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History of a patient with retinoblastoma should be focused on the following factors:<ref name="pmid8299091">{{cite journal |vauthors=Shields CL, Shields JA, Baez K, Cater JR, De Potter P |title=Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors |journal=Cancer |volume=73 |issue=3 |pages=692–8 |date=February 1994 |pmid=8299091 |doi= |url=}}</ref> | History of a patient with retinoblastoma should be focused on the following factors:<ref name="pmid8299091">{{cite journal |vauthors=Shields CL, Shields JA, Baez K, Cater JR, De Potter P |title=Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors |journal=Cancer |volume=73 |issue=3 |pages=692–8 |date=February 1994 |pmid=8299091 |doi= |url=}}</ref> | ||
*Complete perinatal history including: | *Complete perinatal history including: | ||
**Pregnancy complications | **[[Pregnancy complications]] | ||
**Prematurity | **[[Prematurity]] | ||
**Birth weight | **Birth weight | ||
**Type of delivery | **Type of [[delivery]] | ||
**Use of oxygen | **Use of oxygen | ||
*Personal history of: | *Personal history of: | ||
**Malformations | **[[Malformations]] | ||
**Exposure to pets | **Exposure to pets | ||
**Recent trauma | **Recent trauma | ||
**Systemic illness | **Systemic illness | ||
*Family history of: | *[[Family history]] of: | ||
**Genetic disease | **[[Genetic diseases|Genetic disease]] | ||
**Blindness | **[[Blindness]] | ||
**Enucleation | **[[Enucleation]] | ||
**Amblyopia | **[[Amblyopia]] | ||
**Retinoblastoma | **[[Retinoblastoma]] | ||
Clinical [[Features (pattern recognition)|features]] of retinoblatoma are approximately the same in variable studies and the common findings are as follow:<ref name="pmid24792399">{{cite journal |vauthors=Chebbi A, Bouguila H, Boussaid S, Ben Aleya N, Zgholi H, Malek I, Zeghal I, Nacef L |title=[Clinical features of retinoblastoma in Tunisia] |language=French |journal=J Fr Ophtalmol |volume=37 |issue=6 |pages=442–8 |date=June 2014 |pmid=24792399 |doi=10.1016/j.jfo.2014.01.009 |url=}}</ref><ref name="pmid14654593">{{cite journal |vauthors=Abramson DH, Beaverson K, Sangani P, Vora RA, Lee TC, Hochberg HM, Kirszrot J, Ranjithan M |title=Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival |journal=Pediatrics |volume=112 |issue=6 Pt 1 |pages=1248–55 |date=December 2003 |pmid=14654593 |doi= |url=}}</ref><ref name="ShifaGezmu2017">{{cite journal|last1=Shifa|first1=Jemal Zeberga|last2=Gezmu|first2=Alemayehu Mekonnen|title=Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia|journal=Pan African Medical Journal|volume=28|year=2017|issn=1937-8688|doi=10.11604/pamj.2017.28.66.11199}}</ref> | Clinical [[Features (pattern recognition)|features]] of retinoblatoma are approximately the same in variable studies and the common findings are as follow:<ref name="pmid24792399">{{cite journal |vauthors=Chebbi A, Bouguila H, Boussaid S, Ben Aleya N, Zgholi H, Malek I, Zeghal I, Nacef L |title=[Clinical features of retinoblastoma in Tunisia] |language=French |journal=J Fr Ophtalmol |volume=37 |issue=6 |pages=442–8 |date=June 2014 |pmid=24792399 |doi=10.1016/j.jfo.2014.01.009 |url=}}</ref><ref name="pmid14654593">{{cite journal |vauthors=Abramson DH, Beaverson K, Sangani P, Vora RA, Lee TC, Hochberg HM, Kirszrot J, Ranjithan M |title=Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival |journal=Pediatrics |volume=112 |issue=6 Pt 1 |pages=1248–55 |date=December 2003 |pmid=14654593 |doi= |url=}}</ref><ref name="ShifaGezmu2017">{{cite journal|last1=Shifa|first1=Jemal Zeberga|last2=Gezmu|first2=Alemayehu Mekonnen|title=Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia|journal=Pan African Medical Journal|volume=28|year=2017|issn=1937-8688|doi=10.11604/pamj.2017.28.66.11199}}</ref> | ||
*[[Leukocoria]] (an abnormal appearance of the [[retina]] as viewed through the [[pupil]], also known as amaurotic cat's [[Red reflex|eye reflex]]), (Please see below). | *[[Leukocoria]] (an abnormal appearance of the [[retina]] as viewed through the [[pupil]], also known as amaurotic cat's [[Red reflex|eye reflex]]), (Please see below). | ||
Revision as of 14:05, 13 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[3] Simrat Sarai, M.D. [4]
Overview
The hallmark of retinoblastoma is leukocoria which is an abnormal appearance of the retina as viewed through the pupil, also known as amaurotic cat's eye reflex. Other common symptoms include strabismus and proptosis. The clinical presentation depends on the stage of the disease.
History and ymptoms
History
History of a patient with retinoblastoma should be focused on the following factors:[1]
- Complete perinatal history including:
- Pregnancy complications
- Prematurity
- Birth weight
- Type of delivery
- Use of oxygen
- Personal history of:
- Malformations
- Exposure to pets
- Recent trauma
- Systemic illness
- Family history of:
Clinical features of retinoblatoma are approximately the same in variable studies and the common findings are as follow:[2][3][4]
- Leukocoria (an abnormal appearance of the retina as viewed through the pupil, also known as amaurotic cat's eye reflex), (Please see below).
- Strabismus (especially when the macula is involved)
- Decreased visual acquity
- Painful red eye
- Anterior scleral staphyloma
- Hyphema
- Buphthalmia
- Loss of vision
Presenting symptoms in adult onset of the tumor are insidious and are such as:[5]
- Dimness of vision
- Perception of floater
- Pain and redness
Advanced and/or metastatic form of the tumor also presents with constitutional symptoms such as:
- Proptosis
- Weight loss
- Vomiting
- Headache
- Neurologic impairement
- Orbital mass
References
- ↑ Shields CL, Shields JA, Baez K, Cater JR, De Potter P (February 1994). "Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors". Cancer. 73 (3): 692–8. PMID 8299091.
- ↑ Chebbi A, Bouguila H, Boussaid S, Ben Aleya N, Zgholi H, Malek I, Zeghal I, Nacef L (June 2014). "[Clinical features of retinoblastoma in Tunisia]". J Fr Ophtalmol (in French). 37 (6): 442–8. doi:10.1016/j.jfo.2014.01.009. PMID 24792399.
- ↑ Abramson DH, Beaverson K, Sangani P, Vora RA, Lee TC, Hochberg HM, Kirszrot J, Ranjithan M (December 2003). "Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival". Pediatrics. 112 (6 Pt 1): 1248–55. PMID 14654593.
- ↑ Shifa, Jemal Zeberga; Gezmu, Alemayehu Mekonnen (2017). "Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia". Pan African Medical Journal. 28. doi:10.11604/pamj.2017.28.66.11199. ISSN 1937-8688.
- ↑ Khetan, Vikas; Sengupta, Sabyasachi; Pan, Utsab (2016). "Adult onset retinoblastoma". Indian Journal of Ophthalmology. 64 (7): 485. doi:10.4103/0301-4738.190099. ISSN 0301-4738.
- ↑ Image courtesy of Dr. Frank Gaillard Radiopaedia (original file [1]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC