Loefflers syndrome differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Loeffler syndrome must be differentiated from other diseases that cause pulmonary eosinophilia, such as Churg-Strauss, drug and toxin-induced eosinophilic lung diseases, other helminthic and fungal infection related eosinophilic lung diseases, and nonhelminthic infections such as Coccidioidomycosis, and Mycobacterium tuberculosis, .

Differentiating Loeffler syndrome from other pulmonary eosinophilia syndromes on the basis of etiology.

Diseases		Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
		Symptoms			Physical examination
								Lab Findings			Imaging			Histopathology
		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3
Helminthic and fungal infection-related eosinophilic lung diseases	Transpulmonary passage of larvae (Loffler's syndrome)															Ascaris lumbricoides Hookworms such as: Ancylostoma duodenale Necator americanus) Strongyloides stercoralis
	Tropical pulmonary eosinophilia
	Allergic bronchopulmonary aspergillosis
	Heavy hematogenous seeding with helminths
	Pulmonary parenchymal invasion
Nonhelminthic infections	Coccidioidomycosis
	Mycobacterium tuberculosis
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
Drug- and toxin-induced eosinophilic lung diseases																Nonsteroidal antiinflammatory drugs Phenytoin L-tryptophan Antibiotics (nitrofurantoin, minocycline, sulfonamides, ampicillin, daptomycin)
	Acute eosinophilic pneumonia
	Chronic eosinophilic pneumonia
Diseases		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3	Histopathology	Gold standard	Additional findings
	Differential Diagnosis 7
	Differential Diagnosis 7
	Differential Diagnosis 7
	Differential Diagnosis 7