Loefflers syndrome differential diagnosis: Difference between revisions
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{{CMG}}; {{AE}} {{Soroush}} | {{CMG}}; {{AE}} {{Soroush}} | ||
==Overview== | ==Overview== | ||
Loeffler syndrome must be differentiated from other diseases that cause pulmonary eosinophilia, such as Churg-Strauss, drug and toxin-induced eosinophilic lung diseases, other helminthic and fungal infection related eosinophilic lung diseases, and nonhelminthic infections such as Coccidioidomycosis, and Mycobacterium tuberculosis | Loeffler syndrome must be differentiated from other diseases that cause pulmonary eosinophilia, such as Churg-Strauss, drug and toxin-induced eosinophilic lung diseases, other helminthic and fungal infection related eosinophilic lung diseases, and nonhelminthic infections such as Coccidioidomycosis, and Mycobacterium tuberculosis. | ||
===Differentiating Loeffler syndrome from other pulmonary [[eosinophilia]] syndromes on the basis of etiology.=== | ===Differentiating Loeffler syndrome from other pulmonary [[eosinophilia]] syndromes on the basis of etiology.=== |
Revision as of 14:54, 16 May 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]
Overview
Loeffler syndrome must be differentiated from other diseases that cause pulmonary eosinophilia, such as Churg-Strauss, drug and toxin-induced eosinophilic lung diseases, other helminthic and fungal infection related eosinophilic lung diseases, and nonhelminthic infections such as Coccidioidomycosis, and Mycobacterium tuberculosis.
Differentiating Loeffler syndrome from other pulmonary eosinophilia syndromes on the basis of etiology.
Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Physical examination | |||||||||||||||
Lab Findings | Imaging | Histopathology | ||||||||||||||
Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Increased Eosinophil count
(High) |
Increased Eosinophil count
(Mild to moderate) |
Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | |||||
Helminthic
and fungal infection-related eosinophilic lung diseases |
Transpulmonary
passage of larvae (Loffler's syndrome) |
| ||||||||||||||
Tropical
pulmonary eosinophilia |
40 to 70 percent |
| ||||||||||||||
Allergic bronchopulmonary aspergillosis | * | |||||||||||||||
Heavy
hematogenous seeding with helminths |
| |||||||||||||||
Pulmonary parenchymal invasion |
| |||||||||||||||
Nonhelminthic infections | Coccidioidomycosis | |||||||||||||||
Mycobacterium tuberculosis | ||||||||||||||||
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) | * | |||||||||||||||
Drug- and toxin-induced eosinophilic lung diseases | * |
| ||||||||||||||
Acute eosinophilic pneumonia | ||||||||||||||||
Chronic eosinophilic pneumonia | ≥40 percent | |||||||||||||||
Idiopathic acute eosinophilic pneumonia | ≥25 percent | |||||||||||||||
Diseases | Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Increased Eosinophil count
(High) |
Increased Eosinophil count
(Mild to moderate) |
Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | Histopathology | Gold standard | Additional findings | |
Sarcoidosis | * | |||||||||||||||
Pulmonary Langerhans cell histiocytosis (Histiocytosis X) | * | |||||||||||||||
Idiopathic pulmonary fibrosis | <10 percent | |||||||||||||||
Differential Diagnosis 7 |