Squamous cell carcinoma of the skin risk factors: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 12: | Line 12: | ||
Common risk factors for the development of the disease inlcude: | Common risk factors for the development of the disease inlcude: | ||
* UV light exposure | * UV light exposure<ref name="pmid11684448">{{cite journal| author=de Gruijl FR, van Kranen HJ, Mullenders LH| title=UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. | journal=J Photochem Photobiol B | year= 2001 | volume= 63 | issue= 1-3 | pages= 19-27 | pmid=11684448 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11684448 }}</ref> | ||
** UV light damages DNA, initiating a series of changes can result in malignant transformation | ** UV light damages DNA, initiating a series of changes can result in malignant transformation | ||
* Having skin that burns easily and does not tan or tans poorly | * Having skin that burns easily and does not tan or tans poorly | ||
| Line 23: | Line 23: | ||
* Northern European ancestry | * Northern European ancestry | ||
* Exposure to PUVA phototherapy | * Exposure to PUVA phototherapy | ||
* Immunosuppressive treatment | * Immunosuppressive treatment<ref name="pmid10025742">{{cite journal| author=Jensen P, Hansen S, Møller B, Leivestad T, Pfeffer P, Geiran O et al.| title=Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 2 Pt 1 | pages= 177-86 | pmid=10025742 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10025742 }}</ref> | ||
* Exposure to ionizing radiation and other industrial carcinogens | * Exposure to ionizing radiation and other industrial carcinogens<ref name="pmid15704092">{{cite journal| author=Yoshinaga S, Hauptmann M, Sigurdson AJ, Doody MM, Freedman DM, Alexander BH et al.| title=Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists. | journal=Int J Cancer | year= 2005 | volume= 115 | issue= 5 | pages= 828-34 | pmid=15704092 | doi=10.1002/ijc.20939 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15704092 }}</ref> | ||
* Chronic inflammation | * Chronic inflammation<ref name="pmid12843850">{{cite journal| author=Jellouli-Elloumi A, Kochbati L, Dhraief S, Ben Romdhane K, Maalej M| title=[Cancers arising from burn scars: 62 cases]. | journal=Ann Dermatol Venereol | year= 2003 | volume= 130 | issue= 4 | pages= 413-6 | pmid=12843850 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12843850 }}</ref> | ||
* Rare inherited disorders | * Rare inherited disorders | ||
** Xeroderma pigmentosum | ** Xeroderma pigmentosum | ||
| Line 33: | Line 33: | ||
** Fanconi's anemia | ** Fanconi's anemia | ||
* Arsenic exposure | * Arsenic exposure | ||
* Genetic alterations | * Genetic alterations<ref name="pmid15468170">{{cite journal| author=Tsai KY, Tsao H| title=The genetics of skin cancer. | journal=Am J Med Genet C Semin Med Genet | year= 2004 | volume= 131C | issue= 1 | pages= 82-92 | pmid=15468170 | doi=10.1002/ajmg.c.30037 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15468170 }}</ref> | ||
* Family history | * Family history<ref name="pmid23257063">{{cite journal| author=Kharazmi E, Fallah M, Sundquist K, Hemminki K| title=Familial risk of early and late onset cancer: nationwide prospective cohort study. | journal=BMJ | year= 2012 | volume= 345 | issue= | pages= e8076 | pmid=23257063 | doi=10.1136/bmj.e8076 | pmc=3527651 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23257063 }}</ref> | ||
* Drugs | * Drugs | ||
** BRAF inhibitors | ** BRAF inhibitors | ||
Revision as of 21:59, 22 May 2019
|
Squamous cell carcinoma of the skin Microchapters |
|
Differentiating Squamous cell carcinoma of the skin from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Squamous cell carcinoma of the skin risk factors On the Web |
|
American Roentgen Ray Society Images of Squamous cell carcinoma of the skin risk factors |
|
Squamous cell carcinoma of the skin risk factors in the news |
|
Directions to Hospitals Treating Squamous cell carcinoma of the skin |
|
Risk calculators and risk factors for Squamous cell carcinoma of the skin risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]
Overview
The risk factors for the Squamous cell carcinoma (SCC) include prolonged sunlight exposure, UV radiation, smoking, drugs etc.
Risk Factors
Common Risk Factors
Common risk factors for the development of the disease inlcude:
- UV light exposure[1]
- UV light damages DNA, initiating a series of changes can result in malignant transformation
- Having skin that burns easily and does not tan or tans poorly
- Light-colored hair
- Older age
- Smoking
Less Common Risk factors
- Northern European ancestry
- Exposure to PUVA phototherapy
- Immunosuppressive treatment[2]
- Exposure to ionizing radiation and other industrial carcinogens[3]
- Chronic inflammation[4]
- Rare inherited disorders
- Xeroderma pigmentosum
- Epidermolysis bullosa
- Albinism
- Epidermodysplasia verruciformis
- Fanconi's anemia
- Arsenic exposure
- Genetic alterations[5]
- Family history[6]
- Drugs
- BRAF inhibitors
- Voriconazole
- Other photosensitizing drugs like ibuprofen and isotretinoin
References
- ↑ de Gruijl FR, van Kranen HJ, Mullenders LH (2001). "UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer". J Photochem Photobiol B. 63 (1–3): 19–27. PMID 11684448.
- ↑ Jensen P, Hansen S, Møller B, Leivestad T, Pfeffer P, Geiran O; et al. (1999). "Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens". J Am Acad Dermatol. 40 (2 Pt 1): 177–86. PMID 10025742.
- ↑ Yoshinaga S, Hauptmann M, Sigurdson AJ, Doody MM, Freedman DM, Alexander BH; et al. (2005). "Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists". Int J Cancer. 115 (5): 828–34. doi:10.1002/ijc.20939. PMID 15704092.
- ↑ Jellouli-Elloumi A, Kochbati L, Dhraief S, Ben Romdhane K, Maalej M (2003). "[Cancers arising from burn scars: 62 cases]". Ann Dermatol Venereol. 130 (4): 413–6. PMID 12843850.
- ↑ Tsai KY, Tsao H (2004). "The genetics of skin cancer". Am J Med Genet C Semin Med Genet. 131C (1): 82–92. doi:10.1002/ajmg.c.30037. PMID 15468170.
- ↑ Kharazmi E, Fallah M, Sundquist K, Hemminki K (2012). "Familial risk of early and late onset cancer: nationwide prospective cohort study". BMJ. 345: e8076. doi:10.1136/bmj.e8076. PMC 3527651. PMID 23257063.