Morton's neuroma pathophysiology: Difference between revisions

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**[[Thrombosis]]
**[[Thrombosis]]
**Arterial thickening
**Arterial thickening
*On histopathology, it is comprised of:
**Degenerated/demyelinated axons
**Vascular hyalinization
**Fibrosis
[[File:Morton neuroma -- low mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, low magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_low_mag.jpg]]]
{|
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[[File:Morton neuroma - alt -- high mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, High magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_-_alt_--_high_mag.jpg]]]
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[[File:Morton neuroma - alt 1 -- intermed mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, Intermediate magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_-_alt_1_--_intermed_mag.jpg]]]
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[[File:Morton neuroma - alt 2 -- intermed mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, Intermediate magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_-_alt_2_--_intermed_mag.jpg]]]
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[[File:Morton neuroma -- high mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, High magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_high_mag.jpg]]]
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[[File:Morton neuroma -- very high mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, very high magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_very_high_mag.jpg]]]
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[[File:Morton neuroma -- intermed mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, Intermediate magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_intermed_mag.jpg]]]
|}


==References==
==References==

Revision as of 19:48, 31 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [8]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[9]

Overview

Neuroma

Pathogenesis

  • The pathogenesis of neuroma is characterized by neural degeneration with epineural and endoneural vascular hyalinization, and perineural fibrosis[1]
  • Morton neuroma is characterized by being located in the 3rd web-space, between 3rd and 4th metatarsal heads,[2] or sometimes in the second or fourth interspaces
  • On gross pathology, characteristic findings of neuroma, include:[3][4]
  • On microscopic histopathological analysis, characteristic findings of neuroma, include:[3][4]
    • Extensive fibrosis around and within the nerve
    • Digital artery
    • Thrombosis
    • Arterial thickening
  • On histopathology, it is comprised of:
    • Degenerated/demyelinated axons
    • Vascular hyalinization
    • Fibrosis
H&E stain of Morton's neuroma, low magnification [1]
H&E stain of Morton's neuroma, very high magnification [6]
H&E stain of Morton's neuroma, High magnification [2]
H&E stain of Morton's neuroma, Intermediate magnification [3]
H&E stain of Morton's neuroma, Intermediate magnification [4]
H&E stain of Morton's neuroma, High magnification [5]
H&E stain of Morton's neuroma, Intermediate magnification [7]

References

  1. ↑ Neuroma. Radiopedia http://radiopaedia.org/cases/morton-neuroma-2 Accessed on April 21, 2016
  2. ↑ Perry, Arie (2010). Practical surgical neuropathology : a diagnostic approach. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 978-0443069826.
  3. ↑ 3.0 3.1 Neuroma. Wikipedia. https://en.wikipedia.org/wiki/Neuroma Accessed on April 21, 2016
  4. ↑ 4.0 4.1 Wu J, Chiu DT (1999). "Painful neuromas: a review of treatment modalities". Ann Plast Surg. 43 (6): 661–7. PMID 10597831.

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