If lesions are present, they are watched closely for changes in size. Prognosis is best when lesions are less than 3 cm in length. Most complications occur when the lesions are greater than 6 cm in size.<ref name=":0">{{cite journal|last1=SINGH|first1=A|last2=RUNDLE|first2=P|last3=RENNIE|first3=I|title=Retinal Vascular Tumors|journal=Ophthalmology Clinics of North America|date=March 2005|volume=18|issue=1|pages=167–176|doi=10.1016/j.ohc.2004.07.005|url=http://www.ophthalmology.theclinics.com/article/S0896-1549(04)00088-4/fulltext}}</ref> Surgical intervention for intracranial lesions has been done successfully. Nonsurgical treatments include [[embolization]], radiation therapy, and continued observation.<ref name=":3">{{cite journal|last1=Dayani|first1=P. N.|last2=Sadun|first2=A. A.|title=A case report of Wyburn-Mason syndrome and review of the literature|journal=Neuroradiology|date=18 January 2007|volume=49|issue=5|pages=445–456|doi=10.1007/s00234-006-0205-x}}</ref> Arterial vascular malformations may be treated with the [[cyberknife]] treatment. Possible treatment for cerebral arterial vascular malformations include stereotactic radiosurgery, endovascular embolization, and microsurgical resection.<ref name=":0" />
When pursuing treatment, it is important to consider the size of the malformations, their locations, and the neurological involvement.<ref name=":6">{{cite journal|last1=Lester|first1=Jacobo|last2=Ruano-Calderon|first2=Luis Angel|last3=Gonzalez-Olhovich|first3=Irene|title=Wyburn-Mason Syndrome|journal=Journal of Neuroimaging|date=July 2005|volume=15|issue=3|pages=284–285|doi=10.1111/j.1552-6569.2005.tb00324.x}}</ref> Because it is a congenital disorder, there are not preventative steps to take aside from regular follow ups with a doctor to keep an eye on the symptoms so that future complications are avoided.
