Oligodendroglioma other diagnostic studies: Difference between revisions
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Biopsy=== | ===Biopsy=== | ||
*[[Biopsy]] may be [[Performance status|performed]] to help [[Confirmatory factor analysis|confirm]] the [[diagnosis]] of [[oligodendroglioma]] | *[[Biopsy]] may be [[Performance status|performed]] to help [[Confirmatory factor analysis|confirm]] the [[diagnosis]] of [[oligodendroglioma]]. | ||
*On [[biopsy]], [[oligodendroglioma]] is characterized by [[homogeneous]], [[Compact tissue|compact]], rounded [[Cell (biology)|cells]] with [[Distinctive feature|distinct]] borders and clear [[cytoplasm]] surrounding a [[dense]] [[central]] [[nucleus]] and [[Perinuclear space|perinuclear]] [[Halo (medicine)|halo]], giving it the characteristic “''fried [[Egg (biology)|egg]]''” [[appearance]]<ref name="pmid25943885">{{cite journal| author=Wesseling P, van den Bent M, Perry A| title=Oligodendroglioma: pathology, molecular mechanisms and markers. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 6 | pages= 809-27 | pmid=25943885 | doi=10.1007/s00401-015-1424-1 | pmc=PMC4436696 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25943885 }} </ref> | *On [[biopsy]], [[oligodendroglioma]] is characterized by [[homogeneous]], [[Compact tissue|compact]], rounded [[Cell (biology)|cells]] with [[Distinctive feature|distinct]] borders and clear [[cytoplasm]] surrounding a [[dense]] [[central]] [[nucleus]] and [[Perinuclear space|perinuclear]] [[Halo (medicine)|halo]], giving it the characteristic “''fried [[Egg (biology)|egg]]''” [[appearance|appearance.]]<ref name="pmid25943885">{{cite journal| author=Wesseling P, van den Bent M, Perry A| title=Oligodendroglioma: pathology, molecular mechanisms and markers. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 6 | pages= 809-27 | pmid=25943885 | doi=10.1007/s00401-015-1424-1 | pmc=PMC4436696 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25943885 }} </ref> | ||
*[[Biopsy]] may be done at the [[Time series|time]] of [[surgical resection]] of [[oligodendroglioma]] | *[[Biopsy]] may be done at the [[Time series|time]] of [[surgical resection]] of [[oligodendroglioma]]. | ||
*[[Biopsy]] may be of two types: | *[[Biopsy]] may be of two types: | ||
**Open [[biopsy]] | **Open [[biopsy]] | ||
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*[[Surgery|Surgically]] [[Resection|resectable]] [[Mass|masses]] | *[[Surgery|Surgically]] [[Resection|resectable]] [[Mass|masses]] | ||
*[[Lesions]] in [[Accessible image|accessible]] and [[Relatively compact|relatively]] “[[Silent News|silent]]” [[Area|areas]] of the [[brain]] or in [[Area|areas]] of the [[brain]] with a mild postoperative [[Neurological|neurologic]] deficit | *[[Lesions]] in [[Accessible image|accessible]] and [[Relatively compact|relatively]] “[[Silent News|silent]]” [[Area|areas]] of the [[brain]] or in [[Area|areas]] of the [[brain]] with a mild [[Post operative complications|postoperative]] [[Neurological|neurologic]] deficit | ||
*[[Appearance]] consistent with [[tumor]] on the [[MRI]] | *[[Appearance]] consistent with [[tumor]] on the [[MRI]] | ||
*Large [[tumors]] exerting [[mass effect]] | *Large [[tumors]] exerting [[mass effect]] | ||
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===Fluorescent in-situ hybridization (FISH) technique=== | ===Fluorescent in-situ hybridization (FISH) technique=== | ||
*[[FISH]] demonstrates [[Deletion (genetics)|deletions]] of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]]<ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref> | *[[FISH]] demonstrates [[Deletion (genetics)|deletions]] of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q.]]<ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=9 October, 2015 }}</ref> | ||
==References== | ==References== | ||
Latest revision as of 21:03, 4 June 2019
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Oligodendroglioma Microchapters |
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Oligodendroglioma other diagnostic studies On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]
Overview
Other diagnostic studies for oligodendroglioma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).
Other Diagnostic Studies
Biopsy
- Biopsy may be performed to help confirm the diagnosis of oligodendroglioma.
- On biopsy, oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.[1]
- Biopsy may be done at the time of surgical resection of oligodendroglioma.
- Biopsy may be of two types:
- Indications for open biopsy and stereotactic biopsy are described below:[2]
| Type of biopsy | Indications |
|---|---|
| |
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Fluorescent in-situ hybridization (FISH) technique
- FISH demonstrates deletions of chromosome 1p and 19q.[3]
References
- ↑ Wesseling P, van den Bent M, Perry A (2015). "Oligodendroglioma: pathology, molecular mechanisms and markers". Acta Neuropathol. 129 (6): 809–27. doi:10.1007/s00401-015-1424-1. PMC 4436696. PMID 25943885.
- ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 9 October, 2015 Check date values in:
|accessdate=(help)