Erythema gyratum repens

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Gammel's disease.

Historical Perspective

• Erythema gyratum repens was first described by Dr. John A Gammel, the dermatologist, who was trained to link bizarre or recalcitrant dermatoses to internal diseases, In 1952, in a 55-year-old patient who had been complaining of pruritic scaly skin eruption and diagnosed nine months later with poorly differentiated adenocarcinoma of the breast with metastasis to axillary lymph nodes
• In 1950, Dr. Gammel presented his case before the Cleveland Dermatological Society as Erythema gyratum migrans then he changed the term to erythema gyratum repens because the eruption does not "migrate" from one place to another but "crawls" constantly in the areas involved, like ants on an anthill
• The association between cutaneous manifestations and systemic malignancies was first studied in 1925 by Rothman, the Hungarian investigative dermatologist, who wrote a comprehensive review on this subject and since then, cases were added to proof for the relationship between internal neoplasm and some skin lesions
• In 1973, 45 year old man was diagnosed with erythema gyratum repens associated with metastatic, undifferentiated adenocarcinoma which was removed following a right- sided craniotomy. The patient was misdiagnosed with erythema perstans and the malignancy was discovered after 8 months of the skin manifestations.
• Up to 1992, there were only 49 cases in the literature, 41 of which (84%) were associated with a neoplasm
• Between 1990 and 2010, a literature review was done by collecting data from the medical records of patients form dermatology department in University of Genoa and from databases as pubmed and medline, to conclude that erythema gyratum repens is no longer considered as an obligate paraneoplastic syndrome. More than expected cases of EGR were found with no neoplasm association

Classification

• Erythema gyratum repens has no established system for the classification. However, we can classify erythema gyratum repens based on its association with systemic malignancy as:
  • Paraneoplastic EGR
    • Erythema gyratum repens is associated with internal malignancy in 82% of cases
  • Non-paraneoplastic EGR could be:
    • Idiopathic EGR
    • EGR-like eruptions (different dermatologic lesions that mimic EGR)
    • EGR with concomittant skin disease as:
      • pityriasis rubra pilaris, psoriasis, ichthyosis, CREST, rheumatoid arthritis, tuberculosis, bullous pemphigoid, linear IgA disease, and hypereosinophilic syndrome
    • Drug-induced EGR examples are:
      • Azathioprine with type I autoimmune hepatitis
      • Interferon given for hepatitis C virus–related chronic hepatitis

Erythema Gyratum Repens classification
Paraneoplastic erythema gyratum repens	Erythema gyratum repens is associated with internal malignancy in 82% of cases
Non-paraneoplastic erythema gyratum repens
Idiopathic EGR
EGR-like eruptions
EGR with concomittant skin disease	pityriasis rubra pilaris, psoriasis, ichthyosis, CREST, rheumatoid arthritis, tuberculosis, bullous pemphigoid, linear IgA disease, and hypereosinophilic syndrome
Drug-induced EGR	Azathioprine with type I autoimmune hepatitis Interferon given for hepatitis C virus–related chronic hepatitis

Pathophysiology

• The pathogenesis of erythema gyratum repens is unclear
• Many immunologic theories have been implicated in its pathogenesis
• The immunologic mechanism theory is evidenced by the observed immunofluorescence patterns of IgG, C3, and C4 at the basement membrane:
  • Theory 1: the tumor induces antibodies that cross-react with the basement membrane of skin
  • Theory 2: the tumor produces polypeptides that bind skin antigens and render them immunogenic 
  • Theory 3: deposition of tumor antigen-antibody complexes onto the basement membrane causes reactive dermatitis seen in EGR
• The gross appearance of the unique eruptions are:
  • Wavy erythematous concentric bands that can be figurate, gyrate, or annular
  • The bands are arranged in parallel rings and lined by a fine trailing edge of scales, a pattern often described as “wood grained”
  • The distinctive wood grain appearance of the eruption is pathognomonic
  • The rash typically involves large areas of the body but tends to spare the face, hands, and feet and it can expand as fast as 1 cm a day.
  • Bullae can also form from within the areas of erythema
• The microscopic histologic features of erythema gratum repens are not characteristics but the following are the biopsy specimen findings that are compatible with the diagnosis:
  • The epidermis has thin atrophic patches with areas of acanthosis, focal parakeratotic horny layers, and spongiosis
  • The dermis contains a moderate perivascular mononuclear, lymphocytic, and histiocytic infiltrate in the superficial plexus as well as mild focal spongiosis and parakeratosis
  • Eosinophils and melanophages have also been reported in the dermal infiltrate
  • Diffuse to moderate edema of the connective tissue can be seen

Causes

• The exact cause of EGR is unknown
• Various immunologic mechanisms suggest that EGR etiology is stemmed from an immunologic reaction.
• The association between erythema gyratum repens and systemic malignancy is evidenced by the disappearance of the pruritic eruptions after the treatment of the underlying neoplasm.
• The association doesn't necessarily mean causation.

Differentiating Erythema Gyratum Repens from Other Diseases

• EGR has a narrow differential diagnosis. It has to be differentiated from Reactive gyrate erythematous eruptions, such as:
  • Reactive (figurate or gyrate) erythemas that are associated with malignancy include:
    • Erythema annulare centrifugum (EAC)
    • Necrolytic migratory erythema (NME)
  • Reactive (figurate or gyrate) erythemas that are not associated with malignancy include:
    • Erythema marginatum rheumaticum
    • Erythema chronicum migrans   
    • Familial annular erythema
    • The carrier state of chronic granulomatous disease
    • Subacute cutaneous lupus erythematosus
    • Neonatal lupus erythematosus

                                                                                                     Reactive (figurate or gyrate) erythemas with underlying malignancy  

Disease	Erythema Characteristics	Signs and Symptoms	Associated Conditions	Histopathology	Lab finding & Other evaluation	prognosis
Erythema gyratum repens (EGR)	Migratory annular and configurate erythematous bands that form concentric rings Wood grain scaly appearance scales follows the leading edge of the bands Eruption migrates more rapidly, 1cm/d	Skin eruptions severe Generalized itching (pruritus) scaly erythematous patches over trunk and proximal extremities, sparing the hands, feet, and face. Can eventually involve the face    weight loss Malaise and fatigue fever anorexia Lymphadenopathy Headache and convulsion (intracranial metastasis) Shortness of breath (bronchogenic carcinoma)	Dermatologic conditions: ichthyosis palmar/plantar hyperkeratosis Less frequently EGR copresent with: pityriusis rubru piluris, bullous pemphigoid, pemphigus vulgaris, discoid lupus eythemutosus, psoriusiform lesions, and nonspecific vesicles and bullae. Tuberculosis CREST syndrome (calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia).	The epidermis: Acanthosis Focal parakeratotosis and spongiosis The dermis: Mild focal spongiosis and parakeratosis Moderate perivascular mononuclear, lymphocytic, and histiocytic infiltrate Eosinophils and melanophages have also been reported in the infiltrate Diffuse to moderate edema of the connective tissue can be seen	No specific laboratory changes Eosinophilia has been reported Decreased T lymphocytes and increased B lymphocytes observed in an EGR patient with increased luteinizing hormone and follicle-stimulating hormone as well as decreased serum levels of C3    Normal percentages of B and T lymphocytes and normal T-cell function were reported in an EGR patient without cancer Extensive evaluation for possible cancer CBC,CMP, imaging as CT chest or abdomen	Skin manifestations can be improved within 48 hours of the resection of the underlying tumor The improvement sometimes can be temporary with recurrence of the skin lesions specially in cases of metastasis Death can occur any time depending on the type and location of tumor and the timing of its discovery
Erythema annulare centrifugum (EAC)	Migratory annular and configurate erythematous or polycyclic lesions Urticarial in appearance, ringed, arcuate figures Eruption migrate at a slower rate (2 -3 mm/d) reaching up to 10 cm in diameter with central clearing. Cover only a small percentage of the total body surface	annular or polycyclic lesions which may begin as urticaria-like papules Eventually old lesions can spontaneously resolve in several days to a few weeks while new eruptions develop. The deep form of EAC has a firm, indurated border, is rarely pruritic, and has no scale. The superficial type of EAC has an indistinct scaly border and is usually pruritic	Infections Allergic reactions to drugs	Deep form: Mononuclear, perivascular infiltrate in the middle and lower portions of the dermis (coat sleeve-like configuration) Infiltrate is primarily of lymphocytes, but eosinophils are occasionally presen Extravasation of erythrocytes is associated with endothelial swelling    No epidermal changes    Superficial: more non-specific slight superficial perivascular lymphohistiocytic infiltrate    Focal parakeratosis and mild spongiosis with microvesiculation	No specific laboratory changes Eosinophilia of the peripheral blood, as well as tissue, can be observed in EAC associated with a drug reaction or parasitic infection    Evaluation for possible infection or drug reaction (prescribed and non-prescribed) complete blood count, urinalysis, and routine serum liver and kidney function tests.	Lesions disappears after the underlying etiology is managed (allergy, infection, malignancy) if no underlying cause, lesions can recur after discontinuation of the supportive treatment.
Necrolytic migratory erythema (NME)	Migratory circinate erythema/plaques with areas of necrosis and sloughing (3) Crusted  Erythematous scaly plaques with centrifugal growth	Red erythematous scaly plaques over Perineum, distal extremities, lower abdomen, and face Spontaneous exacerbation and remission periods without knowing what the trigger is Weight loss anemia diabetes diarrhea stomatitis.	No other association can be misdiagnosed as contact dermatitis or intertrigo, inverse psoriasis, zinc deficiency, and other nutritional deficiencies	Paleness and spongiosis of the upper layer of the epidermis. A perivascular lymphocytic and histiocytic infiltrate Necrotic keratinocytes are common and can lead to erosions, crusting and scaling	Increased glucagon level (3) Evaluation of the associated tumor: CT or MRI abdomen Selective visceral angiography to localize the tumor Positron Emission tomography (PET) Octreotide scintigraphy	Due to the difficulty of NME recognition, and its association with glucagonoma, diagnosis is usually delayed(3) NME usually resolved after the resection and treatment of the pancreatic tumor, eg 10 days after tumor resection Early recognition is crucial for better diagnosis and prognosis

Epidemiology and Demographics

• EGR is a rare, characteristic, and paraneoplastic syndrome with the following demographics:

Age

• The average age of onset of EGR is in the seventh decade of life (65 years old)

Gender

• The male to female ratio is 2:1

Race

• EGR commonly affects Caucasians

Risk Factors

• There are no established risk factors for EGR
• Many patients with EGR and malignancy had a history of tobacco smoking
• some patients with EGR and malignancy have a family history of neoplasm

Screening

• There are no screening tests for EGR.
• Screening for internal malignancy should be done immediately after EGR is diagnosed.

Natural History, Complications, and Prognosis

• The majority of patients with EGR presents with severely pruritic erythematous skin lesions that appear several months prior to the malignancy diagnosis
• If the underlying malignancy left untreated, the debilitating pruritus could persist until the patient dies
• Prognosis depends on the type of the underlying tumor and the probability of its treatment. It depends on the time of the EGR onset and the neoplasm discovery. The course and prognosis of EGR can be one of the following:
  • Complete cure of the skin eruption and pruritus after removal and treatment of the internal neoplasm
  • Temporary improvement then recurrence of the eruption (specially in cases of metastasis)
  • No effect of the tumor treatment on the course of EGR
  • Death can occur few weeks after the discovery of the malignancy, few months, or four years as in Gammel's patient.

Diagnosis

Diagnostic Study of Choice

• EGR is mainly diagnosed clinically by its characteristic skin lesions.
• It is considered as a cutaneous marker of malignancy with high specificity so physicians shouldn't miss its unique clinical skin presentation.

History and Symptoms

• The universal symptoms of erythema gyratum repens are:
  • Skin eruptions
  • Intense pruritus
• Other symptoms related to the associated internal malignancy may include:
  • Weight loss
  • Fatigue
  • Anorexia
  • Vomiting
  • Fever
  • Headache
  • Convulsion
  • Shortness of breath
  • Abdominal distention

Physical Examination

• Patients with EGR usually are ill-appearing and lethargic
• Physical examination may be remarkable for:
  • Wood-grain erythematous scaly skin eruption
  • Bullae can also form within the areas of erythema
  • Typically involves large areas of the body but tends to spare the face, hands, and feet and it can expands as fast as 1 cm a day
  • Signs of malignancy can be seen based on the neoplasm location such as:
    • Lymphadenopathy
    • Palpable mass
    • abdominal ascites
    • pleural effusion
    • papilloedema

Laboratory Findings

• There are no diagnostic laboratory findings associated with erythema gyratum repens
• Eosinophilia is observed in 60% of cases
• Decreased T lymphocytes and increased B lymphocytes observed in an EGR patient with increased luteinizing hormone and follicle-stimulating hormone
• Decreased serum levels of C3  
• Normal percentages of B and T lymphocytes and normal T-cell function were reported in an EGR patient without cancer

Imaging Findings

• There are no imaging findings associated with EGR
• Imaging to look for systemic neoplasms are:
• * Computed tomography of the head, neck, chest, abdomen, and pelvis
  • Positron emission tomography/computed tomography
  • Upper and lower gastrointestinal endoscopy
• The abnormal findings that heightened concern for systemic or widespread malignancy are:
  • Brain, chest, lung, abdominal, peritoneal, or pelvic mass
  • Lymphadenopathy
  • Enhanced bone lucencies suggestive of diffuse metastasis

Other Diagnostic Studies

• The histopathologic features of EGR is non-specific.
• Biopsy specimens show the following:
  • Acanthosis, mild hyperkeratosis, focal parakeratosis, and spongiosis confined to the epidermis and superficial dermis
  • Mononuclear, lymphocytic, and histiocytic perivascular infiltrate in the superficial plexus can also be seen
  • Eosinophils and melanophages have also been reported in the dermal infiltrate
  • Diffuse to moderate edema of the connective tissue can be seen
  • Direct immunofluorescence can show patterns of IgG, C3, and C4 at the basement membrane
• Thorough paraneoplastic and systemic workup includes:
  • Computed tomography of head, neck, chest, abdomen, and pelvis
  • Positron emission tomography/computed tomography
  • Upper and lower gastrointestinal endoscopy
  • Complete blood chemistry (CBC)
  • Comprehensive metabolic panel (CMP)
  • Urinanalysis
  • Rapid plasma reagin test [to exclude syphilis]
  • Anti-nuclear antibody test [to exclude autoimmune disorders as systemic lupus erythematosus (SLE)]
  • Guaiac stool test
  • Serum protein electrophoresis [to exclude cancers as multiple myeloma]
  • Lactate dehydrogenase [tissue damage, kidney disease, liver disease]
  • QuantiFERON [to exclude tuberculosis]
  • Tumor markers

Treatment

Medical Therapy

• Treatment of erythema gyratum repens, and its associated intense pruritus depends on the recognition and treatment of the underlying malignancy
• Symptomatic management:
  • Hydroxyzine for itching, ibuprofen and oxycodone for pain, and triamcinolone 0.1% cream for the rash
• Management of the neoplasm depends on its type, location, stage, and time of its discovery and on patient preference:
  • Surgical removal
  • Chemotherapy
  • Conservative palliative management
• Various dermatologic and immunosuppressive therapies have been used to treat EGR.
• Systemic steroids are frequently ineffective.
• Topical steroids, vitamin A, and azathioprine have also failed to relieve skin manifestations

Surgery

• Surgical resection of the discovered malignancy could be recommended as part of the management of EGR

Prevention

• Primary prevention:
  • There are no primary preventive measures available for erythema gyratum repens
• Secondary Prevention:
  • If the thorough screening after EGR diagnosis detected the malignancy in its earliest stages
• Tertiary prevention:
  • If the thorough screening after EGR diagnosis detected the malignancy in its late stages or with widespread metastasis
  • Tertiary prevention aims to improve the quality of life and life expectancy.