Ovarian cancer causes: Difference between revisions
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* Ovarian cancer etiology is not | * Ovarian cancer etiology is not completely understood but there are multiple factors that can play a role in its occurrence | ||
* Based on multiple studies, the following can be the causes of ovarian cancer: | * Based on multiple studies, the following can be the causes of ovarian cancer: | ||
** Follicle stimulation or fertility drugs as Clomiphene<ref name="SpirtasKaufman1993">{{cite journal|last1=Spirtas|first1=Robert|last2=Kaufman|first2=Steven C.|last3=Alexander|first3=Nancy J.|title=Fertility drugs and ovarian cancer: red alert or red herring?|journal=Fertility and Sterility|volume=59|issue=2|year=1993|pages=291–293|issn=00150282|doi=10.1016/S0015-0282(16)55670-2}}</ref> | ** Follicle stimulation or fertility drugs as Clomiphene<ref name="SpirtasKaufman1993">{{cite journal|last1=Spirtas|first1=Robert|last2=Kaufman|first2=Steven C.|last3=Alexander|first3=Nancy J.|title=Fertility drugs and ovarian cancer: red alert or red herring?|journal=Fertility and Sterility|volume=59|issue=2|year=1993|pages=291–293|issn=00150282|doi=10.1016/S0015-0282(16)55670-2}}</ref> | ||
* Theories: | |||
* *Theory 1: Repeated ovulations lead to injury of the ovarian epithelium and subsequent exposure to the inflammatory cytokine, transformation of the mesenchymal epithelium, alteration of the genes and hence cancer. | |||
* * With increased age, cortical inclusion cysts develop and its ovarian surface epithelium become metaplastic or neoplastic under the effect of accumulated inflammatory cytokines or stromal factors stimulation <ref name="Ottevanger2017">{{cite journal|last1=Ottevanger|first1=Petronella Beatrix|title=Ovarian cancer stem cells more questions than answers|journal=Seminars in Cancer Biology|volume=44|year=2017|pages=67–71|issn=1044579X|doi=10.1016/j.semcancer.2017.04.009}}</ref> | |||
* * Theory 2: | |||
* Theory 3: | |||
* | * | ||
__NOTOC__ | __NOTOC__ | ||
Revision as of 20:06, 3 July 2019
- Ovarian cancer etiology is not completely understood but there are multiple factors that can play a role in its occurrence
- Based on multiple studies, the following can be the causes of ovarian cancer:
- Follicle stimulation or fertility drugs as Clomiphene[1]
- Theories:
- *Theory 1: Repeated ovulations lead to injury of the ovarian epithelium and subsequent exposure to the inflammatory cytokine, transformation of the mesenchymal epithelium, alteration of the genes and hence cancer.
- * With increased age, cortical inclusion cysts develop and its ovarian surface epithelium become metaplastic or neoplastic under the effect of accumulated inflammatory cytokines or stromal factors stimulation [2]
- * Theory 2:
- Theory 3:
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References
- ↑ Spirtas, Robert; Kaufman, Steven C.; Alexander, Nancy J. (1993). "Fertility drugs and ovarian cancer: red alert or red herring?". Fertility and Sterility. 59 (2): 291–293. doi:10.1016/S0015-0282(16)55670-2. ISSN 0015-0282.
- ↑ Ottevanger, Petronella Beatrix (2017). "Ovarian cancer stem cells more questions than answers". Seminars in Cancer Biology. 44: 67–71. doi:10.1016/j.semcancer.2017.04.009. ISSN 1044-579X.