Hepatopulmonary syndrome differential diagnosis: Difference between revisions

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! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|Histopathology
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|Histopathology
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|-  
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Respiratory symptoms including, shortness of breath, clubbed fingers, and cyanosis.
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Respiratory symptoms  
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Chronic liver disease symptoms including,
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Chronic liver disease symptoms  
Itching, easy bruising, abdominal fullness, decreased libido, abdominal distension, and fatigue.
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Platypnea
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Platypnea
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Orthodeoxia
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Orthodeoxia
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!Diseases
!Diseases
!Respiratory symptoms including, shortness of breath, clubbed fingers, and cyanosis.
!
! colspan="1" rowspan="1" |Chronic liver disease symptoms including,
! colspan="1" rowspan="1" |
Itching, easy bruising, abdominal fullness, decreased libido, abdominal distension, and fatigue.
!
!Platypnea
!
!Orthodeoxia
!
!Chronic liver disease signs
including,
 
spider angioma, red palms, edema, gynecomastia
!Lab 1
!Lab 1
!Lab 2
!Lab 2
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Platypnea (increased shortness of breath when the body is in a vertical position) and orthodeoxia (3-10 mmHg reduction in РаО2 in capillary blood during transition from horizontal to vertical position)


<nowiki>*</nowiki>99mTc scan: lung perfusion scintigraphy with technetium 99mTc labeled macro aggregated albumin
* '''Platypnea''' (increased shortness of breath when the body is in a vertical position) and '''orthodeoxia''' (3-10 mmHg reduction in РаО2 in capillary blood during transition from horizontal to vertical position)
 
* '''99mTc scan''': lung perfusion scintigraphy with technetium 99mTc labeled macro aggregated albumin
 
* '''Chronic liver disease symptoms including,''' Itching, easy bruising, abdominal fullness, decreased libido, abdominal distension, and fatigue.
* '''Chronic liver disease signs''' including, spider angioma, red palms, edema, gynecomastia
* '''Respiratory symptoms''' including, shortness of breath, clubbed fingers, and cyanosis.
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category: (name of the system)]]
[[Category: (name of the system)]]

Revision as of 16:50, 8 July 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]

Overview

Hepatopulmonary syndrome (HPS) must be differentiated from portopulmonary hypertension (PPH) and hereditary hemorrhagic telangiectasia (HHT).

Differentiating Hepatopulmonary Syndrome from other Diseases

Hepatopulmonary syndrome (HPS) must be differentiated from portopulmonary hypertension (PPH) and hereditary hemorrhagic telangiectasia (HHT).

Differentiating hepatopulmonary syndrome from other diseases on the basis of pulse oximetry, arterial blood gas (ABG) analysis , contrast enhanced echocardiography; 99mTc scan: lung perfusion scintigraphy with technetium 99mTc labeled macro aggregated albumin, chest CT scan , pulmonary angiography, and pulmonary function test.

On the basis pulse oximetry, arterial blood gas (ABG) analysis , contrast enhanced echocardiography; 99mTc scan: lung perfusion scintigraphy with technetium 99mTc labeled macro aggregated albumin, chest CT scan , pulmonary angiography, and pulmonary function test, hepatopulmonary syndrome (HPS) must be differentiated from portopulmonary hypertension (PPH) and hereditary hemorrhagic telangiectasia (HHT).[1]

Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Histopathology
Respiratory symptoms Chronic liver disease symptoms Platypnea Orthodeoxia Chronic liver disease signs

including,

spider angioma, red palms, edema, gynecomastia

Pulse oximetry Arterial blood gas (ABG) analysis Pulmonary function test Chest CT scan/Pulmonary angiography 99mTc scan Contrast enhanced echocardiography
Differential Diagnosis 1
Differential Diagnosis 2
Differential Diagnosis 3
Diseases Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3 Histopathology Gold standard Additional findings
Differential Diagnosis 4
Differential Diagnosis 5
Differential Diagnosis 6
  • Platypnea (increased shortness of breath when the body is in a vertical position) and orthodeoxia (3-10 mmHg reduction in РаО2 in capillary blood during transition from horizontal to vertical position)
  • 99mTc scan: lung perfusion scintigraphy with technetium 99mTc labeled macro aggregated albumin
  • Chronic liver disease symptoms including, Itching, easy bruising, abdominal fullness, decreased libido, abdominal distension, and fatigue.
  • Chronic liver disease signs including, spider angioma, red palms, edema, gynecomastia
  • Respiratory symptoms including, shortness of breath, clubbed fingers, and cyanosis.

References

  1. Krynytska I, Marushchak M, Mikolenko A, Bob A, Smachylo I, Radetska L et al. (2017) Differential diagnosis of hepatopulmonary syndrome (HPS): Portopulmonary hypertension (PPH) and hereditary hemorrhagic telangiectasia (HHT). Bosn J Basic Med Sci 17 (4):276-285. DOI:10.17305/bjbms.2017.2020 PMID: 28759737