Ovarian cancer laboratory findings

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• Patients with ovarian cancer can present acutely or sub-acutely
• If there is clinical suspicion of malignancy, the evaluation includes laboratory work, imaging and surgical exploration for the definite diagnosis
• Routine lab work
  • CBC
  • CBP
• Serum biomarkers of epithelial ovarian cancer (EOC):
  • CA 125
    • Considered the best for ovarian cancer detection, therapeutic monitoring, and detection of the tumor recurrence
    • Postmenopausal woman: should be measured
    • Premenopausal woman: should be measured only if US shows highly suspicious malignant mass
  • HE4
  • * A new marker that if tested along with CA125 increases the sensitivity and specificity of ovarian cancer detection
  • OVA1
• **
• Serum biomarkers of the germ cell and sex cord-stromal ovarian cancer:
  • AFP: alpha-fetoprotein
  • hCG: human chorionic gonadotropin
  • LDH: lactate dehydrogenase
  • E2: estradiol
  • Inhibin
  • Testost: testosterone
  • Andro: androstenedione
  • DHEA: dehydroepiandrostenedione
  • AMH: anti-Müllerian hormone