Ovarian cancer historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.

Overview

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Historical Perspective

• In the 16th and 17th centuries, Dr. Lusitani and Dr. Tulp from Holand, believed that cancers are contagious after they noticed the presence of breast cancers in the same household members.
• In 1990, Dr. Mary-Claire King, the professor of genome sciences from Chicago, was the first one to link the single gene on chromosome 17 to many breast and ovarian cancers, after many years of research to find evidence that there is a genetic pattern linked to the incidence of complex diseases.
• In 1991, King named the gene that is linked to many breast and ovarian cancers as BRCA1.
• In 1994, King also found and named the second gene, BRCA2 on chromosome 13.
• 1996, King and the Breast Cancer research foundation, conducted a study on women of Ashkenazi Jewish ancestry in NYC and also on Palestinian women, which lead to the definitive confirmation that mutations in BRCAa and BRCA2 is linked to the incidence of ovarian and breast cancer.