Eye neoplasm: Difference between revisions
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==Diagnosis== | ==Diagnosis== | ||
* [[Melanomas]] ([[choroidal]], [[ciliary body]] and [[uveal]]) - In the early stages there may be no symptoms (the person does not know there is a tumor until an [[ophthalmologist]] or [[optometrist]] looks into the eye with an [[ophthalmoscope]] during a routine test). As the tumor grows, symptoms can be blurred vision, decreased vision, [[double vision]], eventual vision loss and if they continue to grow the [[tumor]] can break past the [[retina]] causing [[retinal detachment]]. Sometimes the tumor can be visible through the [[pupil]]. | |||
* [[Nevus]] - Are [[benign]], [[freckle]] in the eye. These should be checked out and regular checks on the eye done to ensure it hasn't turned into a [[melanoma]]. | |||
* [[Iris]] and [[conjuctival]] tumors (melanomas) - Presents as a dark spot. Any spot which continues to grow on the iris and the conjunctiva should be checked out. | |||
* [[Retinoblastoma]] - [[Strabismus]] (crossed eyes), a whitish or yellowish glow through the pupil, decreasing/loss of vision, sometimes the eye may be red and painful. Retinoblastoma can occur in one or both eyes. This tumor occurs in babies and young children. It is called RB for short. Check photographs, normal healthy eyes would have the [[red eye reflex]], but a white/yellow dot instead of the red eye reflex can indicate a tumor or some other kind of eye disease. Any photos of a child/children which have a white/yellow dot instead of the red eye reflex should be checked out. | |||
==Treatment== | ==Treatment== | ||
Revision as of 19:07, 31 July 2019
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Eye Neoplasm Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Eye neoplasm; eye cancer
Overview
Ocular oncology is the branch of medicine dealing with tumors relating to the eye and its adnexa. Eye cancer can affect all parts of the eye.
Classification
Choroidal tumors
- Choroidal hemangioma
- Choroidal melanoma
- Choroidal metastasis
- Choroidal nevus
- Choroidal osteoma
- Ciliary body melanoma
- The nevus of Ota
Conjunctival tumors
- Conjunctival Kaposi's sarcoma
- Epibulbar dermoid
- Lymphoma of the conjunctiva
- Squamous carcinoma and intraepithelial neoplasia of the conjunctiva
Epidemiology and Demographics
Origin and location
Eye cancers can be primary (starts within the eye) and metastatic cancer (spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer and lung cancer. Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow.
Types
Tumors in the eye and orbit can be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma.
Malignant
The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other parts of the body. Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common orbital malignancy is orbital lymphoma. This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis. Most patients with orbital lymphoma can be offered chemotherapy or radiation therapy.
Adults
- The most common malignant primary intraocular tumor in adults is uveal melanoma. These tumors can occur in the choroid, iris and ciliary body. The latter are sometimes called iris or ciliary body melanoma.
- The next most common is primary intraocular lymphoma (PIOL) which is usually non-Hodgkin’s, large cell lymphoma of the B-cell type, although T cell lymphomas have also been described.
Children
- The most common malignant intraocular tumor in children is retinoblastoma, affecting approximately 325 children per year in North America. Early detection has allowed for cures exceeding 95%.
- The second most common is medulloepithelioma (also called diktyoma) which can occur in the ciliary body and the uvea of the eye.
Benign
Orbital dermoid cysts are benign choristomas which are typically found at the junction of sutures, most commonly at the fronto-zygomatic suture. Large deep orbital dermoid cysts can cause pressure effects on the muscles and optic nerve, leading to diplopia and loss of vision.
Diagnosis
- Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is a tumor until an ophthalmologist or optometrist looks into the eye with an ophthalmoscope during a routine test). As the tumor grows, symptoms can be blurred vision, decreased vision, double vision, eventual vision loss and if they continue to grow the tumor can break past the retina causing retinal detachment. Sometimes the tumor can be visible through the pupil.
- Nevus - Are benign, freckle in the eye. These should be checked out and regular checks on the eye done to ensure it hasn't turned into a melanoma.
- Iris and conjuctival tumors (melanomas) - Presents as a dark spot. Any spot which continues to grow on the iris and the conjunctiva should be checked out.
- Retinoblastoma - Strabismus (crossed eyes), a whitish or yellowish glow through the pupil, decreasing/loss of vision, sometimes the eye may be red and painful. Retinoblastoma can occur in one or both eyes. This tumor occurs in babies and young children. It is called RB for short. Check photographs, normal healthy eyes would have the red eye reflex, but a white/yellow dot instead of the red eye reflex can indicate a tumor or some other kind of eye disease. Any photos of a child/children which have a white/yellow dot instead of the red eye reflex should be checked out.
Treatment
Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Related Chapters