Dermatofibroma history and symptoms: Difference between revisions

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==Overview==
==Overview==
Although typical dermatofibromas cause little or no discomfort, [[itching]] and tenderness can occur.
The majority of [[patients]] with dermatofibroma are [[asymptomatic]]. Dermatofibroma mostly develops as a single slow  growing [[lesion]] on an extremity. Traumatized [[lesion]] may cause [[pain]], [[bleeding]], i[[Itching|tching]], erosive changes,and [[ulceration]].
==Symptoms==
Although typical dermatofibromas cause little or no discomfort, [[itching]] and tenderness can occur.


==Overview==
Multiple dermatofibromas is a [[rare]] variant of [[disease]] which mostly seen in [[patients]] with underlying [[systemic]] [[disorders]].  
The majority of patients with [disease name] are asymptomatic.
 
OR
 
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].


==History and Symptoms==
==History and Symptoms==
*The majority of patients with [disease name] are asymptomatic.
*The majority of [[patients]] with dermatofibroma are [[asymptomatic]]. <ref name="LeeLee2015">{{cite journal|last1=Lee|first1=MiWoo|last2=Lee|first2=WooJin|last3=Jung|first3=JoonMin|last4=Won|first4=ChongHyun|last5=Chang|first5=SungEun|last6=Choi|first6=JeeHo|last7=Moon|first7=KeeChan|title=Clinical and histological patterns of dermatofibroma without gross skin surface change: A comparative study with conventional dermatofibroma|journal=Indian Journal of Dermatology, Venereology, and Leprology|volume=81|issue=3|year=2015|pages=263|issn=0378-6323|doi=10.4103/0378-6323.154795}}</ref>
OR
*Dermatofibroma mostly develops as a single slow  growing [[lesion]] on an extremity.  
*The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
*Traumatized [[lesion]] may cause:<ref name="NaversenTrask1993">{{cite journal|last1=Naversen|first1=Douglas N.|last2=Trask|first2=David M.|last3=Watson|first3=Frank H.|last4=Burket|first4=John M.|title=Painful tumors of the skin: “LEND AN EGG”|journal=Journal of the American Academy of Dermatology|volume=28|issue=2|year=1993|pages=298–300|issn=01909622|doi=10.1016/0190-9622(93)70039-V}}</ref>
*Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. 
**[[Pain]]
Dermatofibromas typically arise slowly and most often occur as a solitary nodule on an extremity, particularly the lower leg, but any cutaneous site is possible. Dermatofibromas are usually asymptomatic, but itching and pain often are noted. They are the most common of all painful skin tumors. [1] Women who shave their legs may be bothered by the razor traumatizing the lesion in that region, causing pain, bleeding, erosive changes, and ulceration. Although cases of unusually rapid growth exist, most dermatofibromas remain static for decades or persist indefinitely. Patients may describe a hard mole or unusual scar and are often concerned about the possibility of skin cancer.
**[[Bleeding]]
 
**[[Itching]]
Several lesions may be present, but rarely are numerous (ie, ≥15) tumors found. This multiple eruptive variant occurs in less than 1% of patients, approximately 60% of whom have an underlying systemic condition, such as HIV infection or systemic lupus erythematosus. [30, 31, 32] However, dermatomyositis, [33] Graves disease, [34] Hashimoto thyroiditis, [35] myasthenia gravis, [35] Down syndrome, [36] leukemia, [37] myelodysplastic syndrome, [38] cutaneous T-cell lymphoma, [39] multiple myeloma, [39] atopic dermatitis, [40] Crohn disease, [41] and ulcerative colitis [42] have all been reported in association with the phenomenon. In addition, antiretroviral agents, [43] the biologic agent efalizumab, [44] antitumor necrosis factor-alpha agents, [45] and the tyrosine kinase inhibitor imatinib [46] have been linked to their appearance.
**Erosive changes
 
**[[Ulceration]]
Both congenital [47] and acquired [48] cases of multiple clustered dermatofibromas have been reported.
*Multiple dermatofibromas is a [[rare]] variant of [[disease]] which mostly seen in [[patients]] with underlying [[systemic]] [[disorders]].
 
Dermatofibromas are slow growing lesions which can affect any part of the body but have a predilection for the extremities. Clinically these lesions are a firm, non-tender cutaneous nodule, with or without overlying skin changes (such as tan-pink to reddish-brown discoloration, depending on the age of the lesion) with a smooth surface. Dermoscopic evaluation of these lesions will most commonly exhibit a central white patch with a peripheral pigmented network. Dermatofibromas are usually less than or equal to one centimeter in diameter. Patients are usually asymptomatic but will relate a history of local trauma at the site of the lesion such as vaccination or an insect bite in approximately one out of five cases. A thorough full body skin exam is important as these lesions may be subtle and are multiple in 10% of cases. The “dimple sign” is a characteristic finding where in lateral inward digital pressure of the skin produces a central dimpling over the lesion. [8] [9]
 
Dermatofibromas typically present as firm, often hyperpigmented, nodules 0.3 to 1 cm in diameter (picture 4A-B), but giant lesions larger than 3 cm in diameter have been described [11,12]. They occur most often in adults and are most commonly located on the lower extremities. Lesions are usually asymptomatic, but may be pruritic. On palpations, dermatofibromas are fixed to the subcutaneous tissues and characteristically dimple when pinched
 
Dermatofibromas usually develop slowly. These small, hard, raised skin growths:
 
Usually, appear on the lower legs, but may appear on the arms or trunk
May be red, pink, purplish, gray or brown and may change color over time
May be as small as a BB pellet but rarely grow larger than a fingernail
Are often painless but may be tender, painful or itchy
Usually, dimple inward when pinched
===History===
Patients with [disease name]] may have a positive history of:
*[History finding 1]
*[History finding 2]
*[History finding 3]
 
===Common Symptoms===
Common symptoms of [disease] include:
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]


===Less Common Symptoms===
Less common symptoms of [disease name] include
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Medicine]]
[[Category:Medicine]]
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[[Category:Up-To-Date]]​
[[Category:Up-To-Date]]
[[Category:Primary care]]
[[Category:Primary care]]
[[Category:Dermatology]]
[[Category:Dermatology]]

Revision as of 13:30, 8 August 2019


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]

Overview

The majority of patients with dermatofibroma are asymptomatic. Dermatofibroma mostly develops as a single slow growing lesion on an extremity. Traumatized lesion may cause pain, bleeding, itching, erosive changes,and ulceration.

Multiple dermatofibromas is a rare variant of disease which mostly seen in patients with underlying systemic disorders.

History and Symptoms

References

  1. ↑ Lee, MiWoo; Lee, WooJin; Jung, JoonMin; Won, ChongHyun; Chang, SungEun; Choi, JeeHo; Moon, KeeChan (2015). "Clinical and histological patterns of dermatofibroma without gross skin surface change: A comparative study with conventional dermatofibroma". Indian Journal of Dermatology, Venereology, and Leprology. 81 (3): 263. doi:10.4103/0378-6323.154795. ISSN 0378-6323.
  2. ↑ Naversen, Douglas N.; Trask, David M.; Watson, Frank H.; Burket, John M. (1993). "Painful tumors of the skin: "LEND AN EGG"". Journal of the American Academy of Dermatology. 28 (2): 298–300. doi:10.1016/0190-9622(93)70039-V. ISSN 0190-9622.
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