Germ cell tumor causes: Difference between revisions
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* Individuals with Differences of Sex Development (DSDs) are predisposed to gonadal germ cell tumor (GCT) | |||
* | |||
* Common causes of seminoma may include:<ref name="pmid23519268">{{cite journal |vauthors=Ferguson L, Agoulnik AI |title=Testicular cancer and cryptorchidism |journal=Front Endocrinol (Lausanne) |volume=4 |issue= |pages=32 |date=2013 |pmid=23519268 |doi=10.3389/fendo.2013.00032 |url=}}</ref><ref name="pmid11061944">{{cite journal |vauthors=Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH |title=Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma? |journal=J. Urol. |volume=164 |issue=6 |pages=2143–4 |date=December 2000 |pmid=11061944 |doi= |url=}}</ref> | * Common causes of seminoma may include:<ref name="pmid23519268">{{cite journal |vauthors=Ferguson L, Agoulnik AI |title=Testicular cancer and cryptorchidism |journal=Front Endocrinol (Lausanne) |volume=4 |issue= |pages=32 |date=2013 |pmid=23519268 |doi=10.3389/fendo.2013.00032 |url=}}</ref><ref name="pmid11061944">{{cite journal |vauthors=Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH |title=Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma? |journal=J. Urol. |volume=164 |issue=6 |pages=2143–4 |date=December 2000 |pmid=11061944 |doi= |url=}}</ref> | ||
* Cryptorchidism | * Cryptorchidism | ||
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* Seminoma is caused by a mutation in the KIT gene. | * Seminoma is caused by a mutation in the KIT gene. | ||
* 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases. | * 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases. | ||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||
Revision as of 19:46, 15 August 2019
- Individuals with Differences of Sex Development (DSDs) are predisposed to gonadal germ cell tumor (GCT)
- Common causes of seminoma may include:[1][2]
- Cryptorchidism
- Undescended testis
- Abdominal testis
- Trauma
- Mumps
- Maternal estrogen exposure
- Genetic Causes
- Seminoma is caused by a mutation in the KIT gene.
- 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.
References
- ↑ Ferguson L, Agoulnik AI (2013). "Testicular cancer and cryptorchidism". Front Endocrinol (Lausanne). 4: 32. doi:10.3389/fendo.2013.00032. PMID 23519268.
- ↑ Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH (December 2000). "Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma?". J. Urol. 164 (6): 2143–4. PMID 11061944.