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Sara Mohsin (talk | contribs) (Replaced content with "__NOTOC__ {{CMG}}; {{AE}} {{S.M.}}") Tag: Replaced |
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{{CMG}}; {{AE}} {{S.M.}} | {{CMG}}; {{AE}} {{S.M.}} | ||
[[Microscopic]] [[Features (pattern recognition)|features]] include: | |||
* Non-circumscribed | |||
* Highly cellular with cells having following characteristics: | |||
** Monomorphic | |||
** Thin | |||
** Spindly | |||
** Scant eosinophilic cytoplasm | |||
** Hyperchromatic nuclei (resembling neurofibroma) | |||
* Tight storiform pattern (cells radiating in spokes at right angles around a central point that often contains a vessel) infiltrating deeply into subcutaneous tissue and entraping fat cells to form a characteristic honeycomb pattern | |||
* Areas of fascicular growth (seen in some cases) | |||
* The early plaque stage may lack the particular storiform pattern | |||
* Many non-atypical mitotic figures may be present | |||
* Non-polarized, thin collagen | |||
* Mild pleomorphism (not significant) | |||
* Focal atypia | |||
* May coexist with giant cell fibroblastoma | |||
* Absent or rare histiocytes | |||
* Following cell types are absent: | |||
** Histiocyte-like cells | |||
** Foam cells | |||
** Giant cells | |||
** Other inflammatory cells | |||
* Different '''variants''' include: | |||
** Atrophic (depressed lesion) | |||
** Collagenous (with central thick collagen bundles) | |||
** Granular cell (S100 negative) | |||
** Myxoid | |||
** Palisading | |||
** Pigmented | |||
** Sclerosing | |||
Revision as of 22:53, 15 August 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Microscopic features include:
- Non-circumscribed
- Highly cellular with cells having following characteristics:
- Monomorphic
- Thin
- Spindly
- Scant eosinophilic cytoplasm
- Hyperchromatic nuclei (resembling neurofibroma)
- Tight storiform pattern (cells radiating in spokes at right angles around a central point that often contains a vessel) infiltrating deeply into subcutaneous tissue and entraping fat cells to form a characteristic honeycomb pattern
- Areas of fascicular growth (seen in some cases)
- The early plaque stage may lack the particular storiform pattern
- Many non-atypical mitotic figures may be present
- Non-polarized, thin collagen
- Mild pleomorphism (not significant)
- Focal atypia
- May coexist with giant cell fibroblastoma
- Absent or rare histiocytes
- Following cell types are absent:
- Histiocyte-like cells
- Foam cells
- Giant cells
- Other inflammatory cells
- Different variants include:
- Atrophic (depressed lesion)
- Collagenous (with central thick collagen bundles)
- Granular cell (S100 negative)
- Myxoid
- Palisading
- Pigmented
- Sclerosing