Adenomatoid tumor: Difference between revisions

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**Solid (plexiform): cells have a more epithelial appearance
**Solid (plexiform): cells have a more epithelial appearance
**Cystic (mixed): rare; tumor is in form of cystic spaces lined by cuboidal to flattened lining epithelium
**Cystic (mixed): rare; tumor is in form of cystic spaces lined by cuboidal to flattened lining epithelium
===Cytology==
*Smears are moderately cellular with sheets of monotonous round to oval cells showing indistinct cell borders and moderate to abundant pale cytoplasm with vacuolations
*Nuclei are eccentric in location but regular with inconspicuous nucleoli
===Immunostaining===
*Adenomatoid tumor stains positive for:
**Calretinin
**Pan cytokeratins (EMA, AE1 / AE3, Cam5.2)
**CK5 / 6
**CK7 (variable, focal to diffuse)
*Adenomatoid tumor stains negative for:
**Vascular / endothelial markers (CD31, CD34)
**CEA
**HBME1
**Factor VIII Ag
**MOC31 / BerEP4
**B72.3
**CD15
**Ulex europeus agglutinin I
**Germ cell markers including:
***OCT3 / 4
***SOX2
***AFP
***PLAP
***CD117
***CD30
***NANOG


==Diagnosis==
==Diagnosis==

Revision as of 16:08, 19 August 2019

Adenomatoid tumor
ICD-O: 9054/0
MeSH D018254

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

Adenomatoid tumor is a mesothelial tumor. It generally presents in the genital tract, in regions such as the testis and epididymis.However, it also has been found in the pancreas.

Pathophysiology

  • Adenomatoid tumors are benign, solid extratesticular lesions that can originate from the epididymis, tunica vaginalis, or spermatic cord.[1][2][3]
  • They are the most common tumor of the epididymis.[4][5]
  • They occur more often in the lower pole than in the upper pole by a ratio of 4:1.[6][7][8]
  • Usually an incidental finding, adenomatoid tumors manifest as a painless scrotal mass, with the majority diagnosed in patients aged 20–50 years.[9][10][11]
  • They are typically unilateral and occur more frequently on the left side. When they grow noninvasively into the testicular parenchyma, they can simulate intratesticular disease.[12][13][14][15]

Gross pathology

  • 1 - 5 cm, well circumscribed solid tumor, adherent to testis / testicular adnexa
  • Cut surface may have small cystic spaces

Histopathology

  • No distinct growth pattern
  • Unencapsulated, cuboidal to flat cells forming cords that are either epithelial-like or form channels with dilated lumina simulating vessels
  • Cells have acidophilic cytoplasm with cytoplasmic vacuoles
  • Nuclei lack nucleoli
  • Mitoses and necrosis are usually absent
  • Intervening stroma may have smooth muscle and elastic fibers, desmoplastic quality and inflammatory cells
  • Rarely, tumor may extend into testicular parenchyma or even rarer, be totally inside the testis[5][13]
  • Patterns have been described but most tumors show a mixture of:[16][17][18][19][20]
    • Adenomatoid (tubular): glandular pattern with cytoplasmic vacuoles giving a signet ring appearance
    • Angiomatoid (canalicular): cells have a more endothelial appearance
    • Solid (plexiform): cells have a more epithelial appearance
    • Cystic (mixed): rare; tumor is in form of cystic spaces lined by cuboidal to flattened lining epithelium

=Cytology

  • Smears are moderately cellular with sheets of monotonous round to oval cells showing indistinct cell borders and moderate to abundant pale cytoplasm with vacuolations
  • Nuclei are eccentric in location but regular with inconspicuous nucleoli

Immunostaining

  • Adenomatoid tumor stains positive for:
    • Calretinin
    • Pan cytokeratins (EMA, AE1 / AE3, Cam5.2)
    • CK5 / 6
    • CK7 (variable, focal to diffuse)
  • Adenomatoid tumor stains negative for:
    • Vascular / endothelial markers (CD31, CD34)
    • CEA
    • HBME1
    • Factor VIII Ag
    • MOC31 / BerEP4
    • B72.3
    • CD15
    • Ulex europeus agglutinin I
    • Germ cell markers including:
      • OCT3 / 4
      • SOX2
      • AFP
      • PLAP
      • CD117
      • CD30
      • NANOG

Diagnosis

Ultrasound findings

  • On an ultrasound, they appear as a solid extratesticular mass with variable echogenicity.[21]

MRI

  • Commonly, MRI demonstrates low signal intensity relative to the testicular parenchyma on T2-weighted images.
  • MRI can aid in determining the paratesticular origin of the lesion.
  • Adenomatoid tumors enhance after administration of gadolinium contrast material.


T2
T2
STIR
T1 pre contrast
T1 post GAD

Treatment

  • Complete excision
  • Frozen section examination may prevent unnecessary radical orchiectomy[22][23]

Differentiating Adenomatoid tumor from other diseases

  • Adenomatoid tumor must be differentiated from:
    • Malignant mesothelioma (HBME1+, mitoses and necrosis)
    • Metastatic adenocarcinoma (positive for one or more of CEA, PSA, MOC31 / BerEP4 and CD15 are useful)
    • Papillary cystadenoma of epididymis

References

  1. ↑ Amin W, Parwani AV (2009). "Adenomatoid tumor of testis". Clin Med Pathol. 2: 17–22. PMC 2990235. PMID 21151545.
  2. ↑ Williams SB, Han M, Jones R, Andrawis R (2004). "Adenomatoid tumor of the testes". Urology. 63 (4): 779–81. doi:10.1016/j.urology.2003.11.035. PMID 15072910.
  3. ↑ Alam K, Maheshwari V, Varshney M, Aziz M, Shahid M, Basha M; et al. (2011). "Adenomatoid tumour of testis". BMJ Case Rep. 2011. doi:10.1136/bcr.01.2011.3790. PMC 3063256. PMID 22707658.
  4. ↑ "Adenomatoid tumor of the epididymis". Retrieved 2007-12-15.
  5. ↑ 5.0 5.1 Migliorini F, Baldassarre R, Artibani W, Martignoni G, Brunelli M (2014). "Rare case of intra-testicular adenomatoid tumour". Arch Ital Urol Androl. 86 (1): 44–5. doi:10.4081/aiua.2014.1.44. PMID 24704932.
  6. ↑ Oyama H, Ogawa M, Mikuriya H, Kido A, Hayashi H (2001). "[Adenomatoid tumor of testicular tunica albuginea: a case report]". Hinyokika Kiyo. 47 (9): 661–3. PMID 11692607.
  7. ↑ Shima M, Takahashi S, Maeda T, Masumori N, Itoh N, Tsukamoto T (2009). "[Adenomatoid tumor of the testis with testicular pain: a case report]". Hinyokika Kiyo. 55 (5): 285–6. PMID 19507549.
  8. ↑ Kalyani R, Das S (2009). "Adenomatatoid tumor: Cytological diagnosis of two cases". J Cytol. 26 (1): 30–2. doi:10.4103/0970-9371.54865. PMC 3167987. PMID 21938146.
  9. ↑ Barry P, Chan KG, Hsu J, Quek ML (2005). "Adenomatoid tumor of the tunica albuginea". Int J Urol. 12 (5): 516–8. doi:10.1111/j.1442-2042.2005.01091.x. PMID 15948758.
  10. ↑ Chen D, Yu Z, Ni L, Gui Y, Yang S, Shi B; et al. (2014). "Adenomatoid tumors of the testis: A report of two cases and review of the literature". Oncol Lett. 7 (5): 1718–1720. doi:10.3892/ol.2014.1938. PMC 3997688. PMID 24765207.
  11. ↑ Alexiev BA, Xu LF, Heath JE, Twaddell WS, Phelan MW (2011). "Adenomatoid tumor of the testis with intratesticular growth: a case report and review of the literature". Int J Surg Pathol. 19 (6): 838–42. doi:10.1177/1066896911398656. PMID 21427102.
  12. ↑ "Modern Pathology - Adenomatoid Tumor of the Pancreas: A Case Report with Comparison of Histology and Aspiration Cytology". Retrieved 2007-12-15.
  13. ↑ 13.0 13.1 Samad AA, Pereiro B, Badiola A, Gallego C, Zungri E (1996). "Adenomatoid tumor of intratesticular localization". Eur Urol. 30 (1): 127–8. PMID 8854081.
  14. ↑ Pichler R, Tulchiner G, Steinkohl F, Soleiman A, Horninger W, Heidegger IM; et al. (2018). "Adenomatoid tumor of the testis mimicking malignant testicular cancer on multiparametric ultrasound". Eur J Med Res. 23 (1): 3. doi:10.1186/s40001-018-0301-5. PMC 5765709. PMID 29325584.
  15. ↑ Makkar M, Dayal P, Gupta C, Mahajan N (2013). "Adenomatoid tumor of testis: A rare cytological diagnosis". J Cytol. 30 (1): 65–7. doi:10.4103/0970-9371.107519. PMC 3643368. PMID 23661947.
  16. ↑ Taxy JB, Battifora H, Oyasu R (1974). "Adenomatoid tumors: a light microscopic, histochemical, and ultrastructural study". Cancer. 34 (2): 306–16. doi:10.1002/1097-0142(197408)34:2<306::aid-cncr2820340214>3.0.co;2-g. PMID 4277347.
  17. ↑ Quigley JC, Hart WR (1981). "Adenomatoid tumors of the uterus". Am J Clin Pathol. 76 (5): 627–35. doi:10.1093/ajcp/76.5.627. PMID 7293978.
  18. ↑ Yo H, Mori O, Ohaki Y, Kawamura T, Asano G (1996). "[Three cases of adenomatoid tumor of the uterus]". Nihon Ika Daigaku Zasshi. 63 (4): 294–8. PMID 8810558.
  19. ↑ Cheng CL, Wee A (2003). "Diffuse uterine adenomatoid tumor in an immunosuppressed renal transplant recipient". Int J Gynecol Pathol. 22 (2): 198–201. PMID 12649678.
  20. ↑ Otis CN (1996). "Uterine adenomatoid tumors: immunohistochemical characteristics with emphasis on Ber-EP4 immunoreactivity and distinction from adenocarcinoma". Int J Gynecol Pathol. 15 (2): 146–51. PMID 8786204.
  21. ↑ Urkmez A, Akan S, Ozsoy E, Sahin A, Koca O, Ozturk MI (2018). "Diagnosis and Treatment of Paratesticular Adenomatoid Tumors". J Coll Physicians Surg Pak. 28 (9): S217–S219. doi:10.29271/jcpsp.2018.09.S217. PMID 30173704.
  22. ↑ Goel A, Jain A, Dalela D (2011). "Can radical orchiectomy be avoided for paratesticular adenomatoid tumor?". Indian J Urol. 27 (4): 556–7. doi:10.4103/0970-1591.91454. PMC 3263233. PMID 22279331.
  23. ↑ Subik MK, Gordetsky J, Yao JL, di Sant'Agnese PA, Miyamoto H (2012). "Frozen section assessment in testicular and paratesticular lesions suspicious for malignancy: its role in preventing unnecessary orchiectomy". Hum Pathol. 43 (9): 1514–9. doi:10.1016/j.humpath.2011.11.013. PMID 22406369.



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