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{{Medullary thyroid cancer}}
{{Medullary thyroid cancer}}
{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
==Gallery==
On biopsy, medullary thyroid cancer is characterized by interstitial edema and coarse calcifications.
==Key Biopsy Findings in Medullary Thyroid Cancer==
===Microscopic Pathology===
* Microscopic features of medullary thyroid cancer is as follows:
====Cytoplasm and Nuclei====
:* Nested with delicate vascular septa
:* Trabecular cells
:* Tubular/glandular, pseudo-papillary cells
:* Polygonal to spindle to small cells
:* Amphophilic, somewhat granular cytoplasm
:* Interstitial edema
:* Vascular stroma may have amyloid deposits with fluffy appearing acellular eosinophilic material in the cytoplasm
:* Stroma can show hemorrhage, hyalinised collagen, oedema or metaplastic bone
:* Coarse calcification and psammoma bodies may be present
:* Nuclei with "neuroendocrine features"
:* Small, round nuclei.
:* Coarse chromatin (salt and pepper nuclei)
====Surrounding Thyroid====
:* +/-C-cell hyperplasia - seen with familial forms of medullary thyroid cancer
:* C cells (AKA parafollicular cell): abundant cytoplasm - clear/pale
==Biopsy Exams of Medullary Thyroid Cancer==
<gallery>
<gallery>
Image:Medullary thyroid carcinoma - low mag.jpg| Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
Image:Medullary thyroid carcinoma - low mag.jpg| Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology

Revision as of 16:24, 21 August 2019

Medullary thyroid cancer Microchapters

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Overview

Historical Perspective

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Causes

Differentiating Medullary thyroid cancer from other Diseases

Epidemiology and Demographics

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Natural History, Complications and Prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Gallery

  • Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
    Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
  • High magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
    High magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
  • High magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
    High magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
  • Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
    Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
  • Medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
    Medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology

References

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