Extranodal NK-T-cell lymphoma classification: Difference between revisions
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{{CMG}}; {{AE}} {{RG}} {{AS}} | {{CMG}}; {{AE}} {{RG}} {{AS}} | ||
==Overview== | ==Overview== | ||
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial. Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: | In contrast with B-cell lymphoma, classification of such a rare [[neoplasm]] has been controversial. Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: [[Natural killer|NK]] cell-derived [[neoplasms]], namely, aggressive NK cell leukemia and extranodal NK-T-cell lymphoma, nasal type. Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type, and extranodal NK-T-cell lymphoma, extra nasal type which contains two major subclass: [[Enteropathy]] type and [[subcutaneous]] panniculitis-like. | ||
==Classification== | ==Classification== | ||
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar | In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matter, clinical features became handier for classification and somehow even more important than the precise cell of origin.<ref name="BioMedCentral"> Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016 </ref><ref name="Hindawi">Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016, </ref> | ||
Since the majority of [[Cytotoxic T-cells|cytotoxic T-cell]] and NK cell lymphomas are located out of [[lymph nodes]], the gene expressing cytotoxic molecules may predispose to [[apoptosis]] by [[tumor]] cells and by standard cells. | |||
Three major categories of extranodal T/NK cell tumors | Three major categories of extranodal T/NK cell tumors include:<ref name="pmid12876666">{{cite journal| author=Jaffe ES, Krenacs L, Raffeld M| title=Classification of cytotoxic T-cell and natural killer cell lymphomas. | journal=Semin Hematol | year= 2003 | volume= 40 | issue= 3 | pages= 175-84 | pmid=12876666 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12876666 }} </ref> | ||
* Extranodal NK/T , nasal type lymphoma | * Extranodal NK/T-cell lymphoma, nasal type lymphoma | ||
* Extranodal NK/T , | * Extranodal NK/T-cell lymphoma, [[enteropathy]] type lymphoma | ||
* Extranodal NK/T ,subcutaneous panniculitis-like | * Extranodal NK/T-cell lymphoma, [[subcutaneous]] panniculitis-like | ||
Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: | Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: | ||
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! style="background: #4479BA;; color:#FFF;" | Description | ! style="background: #4479BA;; color:#FFF;" | Description | ||
|- | |- | ||
! style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | Extranodal NK-T-cell lymphoma, nasal type | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
* Most commonly affects the nose or nasal passages and [[paranasal sinuses]] | * Most commonly affects the nose or nasal passages and [[paranasal sinuses]] | ||
|- | |- | ||
! style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | Extranodal NK-T-cell lymphoma, extra nasal type | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
* Can affect the: | * Can affect the: | ||
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=== Natural Killer cell neoplasms are classified by the world health organization (WHO) into:<ref name="pmid23816348">{{cite journal| author=Lima M| title=Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis. | journal=Orphanet J Rare Dis | year= 2013 | volume= 8 | issue= | pages= 95 | pmid=23816348 | doi=10.1186/1750-1172-8-95 | pmc=3770456 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23816348 }} </ref> === | === Natural Killer cell neoplasms are classified by the world health organization (WHO) into:<ref name="pmid23816348">{{cite journal| author=Lima M| title=Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis. | journal=Orphanet J Rare Dis | year= 2013 | volume= 8 | issue= | pages= 95 | pmid=23816348 | doi=10.1186/1750-1172-8-95 | pmc=3770456 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23816348 }} </ref> === | ||
* NK/T-cell lymphoma, nasal type (NKTCL) | |||
* Aggressive NK-cell leukemia (ANKCL) | |||
* Chronic lymphoproliferative disorders of [[NK-cells|NK-cell]] <br /> | |||
==References== | ==References== | ||
Revision as of 15:11, 22 August 2019
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Extranodal NK-T-cell lymphoma Microchapters |
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Differentiating Extranodal NK-T-cell lymphoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Extranodal NK-T-cell lymphoma classification On the Web |
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American Roentgen Ray Society Images of Extranodal NK-T-cell lymphoma classification |
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Risk calculators and risk factors for Extranodal NK-T-cell lymphoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial. Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes: NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extranodal NK-T-cell lymphoma, nasal type. Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type, and extranodal NK-T-cell lymphoma, extra nasal type which contains two major subclass: Enteropathy type and subcutaneous panniculitis-like.
Classification
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matter, clinical features became handier for classification and somehow even more important than the precise cell of origin.[1][2]
Since the majority of cytotoxic T-cell and NK cell lymphomas are located out of lymph nodes, the gene expressing cytotoxic molecules may predispose to apoptosis by tumor cells and by standard cells.
Three major categories of extranodal T/NK cell tumors include:[3]
- Extranodal NK/T-cell lymphoma, nasal type lymphoma
- Extranodal NK/T-cell lymphoma, enteropathy type lymphoma
- Extranodal NK/T-cell lymphoma, subcutaneous panniculitis-like
Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes:
- NK cell-derived neoplasms, namely, aggressive NK cell leukemia
- Extranodal NK/T-cell lymphoma, nasal type
Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into:[4][1]
- Extranodal NK-T-cell lymphoma, nasal type
- Extranodal NK-T-cell lymphoma, extra nasal type
| Name | Description |
|---|---|
| Extranodal NK-T-cell lymphoma, nasal type |
|
| Extranodal NK-T-cell lymphoma, extra nasal type |
|
Natural Killer cell neoplasms are classified by the world health organization (WHO) into:[5]
- NK/T-cell lymphoma, nasal type (NKTCL)
- Aggressive NK-cell leukemia (ANKCL)
- Chronic lymphoproliferative disorders of NK-cell
References
- ↑ 1.0 1.1 Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016
- ↑ Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016,
- ↑ Jaffe ES, Krenacs L, Raffeld M (2003). "Classification of cytotoxic T-cell and natural killer cell lymphomas". Semin Hematol. 40 (3): 175–84. PMID 12876666.
- ↑ Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016
- ↑ Lima M (2013). "Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis". Orphanet J Rare Dis. 8: 95. doi:10.1186/1750-1172-8-95. PMC 3770456. PMID 23816348.