Extranodal NK-T-cell lymphoma causes: Difference between revisions
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==Overview== | ==Overview== | ||
Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.P53 overexpresion has assosiation with poor prognosis. | |||
==Causes== | ==Causes== | ||
=== Genetic causes: === | |||
* Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.<ref name="AozasaTakakuwa2008">{{cite journal|last1=Aozasa|first1=Katsuyuki|last2=Takakuwa|first2=Tetsuya|last3=Hongyo|first3=Tadashi|last4=Yang|first4=Woo-Ick|title=Nasal NK/T-cell lymphoma: epidemiology and pathogenesis|journal=International Journal of Hematology|volume=87|issue=2|year=2008|pages=110–117|issn=0925-5710|doi=10.1007/s12185-008-0021-7}}</ref> | |||
* Genetic instability of micro satellites was not found in cases with the disease.<ref name="pmid8069852">{{cite journal| author=Greenblatt MS, Bennett WP, Hollstein M, Harris CC| title=Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. | journal=Cancer Res | year= 1994 | volume= 54 | issue= 18 | pages= 4855-78 | pmid=8069852 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8069852 }}</ref> | |||
* P53 overexpresion has assosiation with poor prognosis. | |||
==References== | ==References== | ||
Revision as of 21:10, 23 August 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.P53 overexpresion has assosiation with poor prognosis.
Causes
Genetic causes:
- Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.[1]
- Genetic instability of micro satellites was not found in cases with the disease.[2]
- P53 overexpresion has assosiation with poor prognosis.
References
- ↑ Aozasa, Katsuyuki; Takakuwa, Tetsuya; Hongyo, Tadashi; Yang, Woo-Ick (2008). "Nasal NK/T-cell lymphoma: epidemiology and pathogenesis". International Journal of Hematology. 87 (2): 110–117. doi:10.1007/s12185-008-0021-7. ISSN 0925-5710.
- ↑ Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994). "Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis". Cancer Res. 54 (18): 4855–78. PMID 8069852.