Extranodal NK-T-cell lymphoma medical therapy: Difference between revisions

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Revision as of 14:23, 30 August 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD [2]

Overview

The predominant therapy for extranodal NK-T-cell lymphoma is radiation therapy. Adjudicative chemotherapy and stem cell transplant may be required.

Medical Therapy

The predominant therapy for extranodal NK-T-cell lymphoma is radiation therapy. Adjudicative chemotherapy and stem cell transplant may be required.^[1]
Therapy of extranodal NK/T cell lymphoma depends on staging of the tumor:^[2]^[3]^[4]^[5]

**Favored treatment of extranodal NK/T cell lymphoma** based on staging
Stage	Involvement	Common involvement place	Preferred therapy method	Radiation dosage	Chemotherapy regimen	Alternative therapy	Over 69 /severe organ damage/low lymphocyte
I(E)	Single extranodal involvement	upper aerodigestive tract	Combined modality therapy‡	50 Gy RT	DeVIC∞	40 Gy RT + weekly Cisplatin	-
II(E)	Stage I(E) +One or more of † involvements	upper aerodigestive tract	Combined modality therapy	50 Gy RT	DeVIC	40 Gy RT + weekly Cisplatin	-
III(E)•	Stage I (E) + Cervical lymph node involvement + infra diaphragmatic lymph node / Involvement of spleen	Systemic / Disseminated	SMILE៛	-	-		Less intensive L-asparaginase-containing chemotherapy
IV	Stage I(E) +isolated distant involvement	Systemic / Disseminated	SMILE	-	-		Less intensive L-asparaginase-containing chemotherapy

†: Cervical lymph node involvement / Involvement of other supradiaphragmatic lymph node regions / Isolated involvement of additional sites in the head and neck

•: Rare

‡: Combined modality therapy is radiation therapy with concurrent chemotherapy

∞: Dexamethasone, Etoposide, Ifosfamide, Carboplatin.

៛: Dexamethasone. Methotrexate, Ifosfamide, L-asparaginase, Etoposide

**Treatment of extranodal NK-T-cell lymphoma^[1]**
Therapy	Description
Radiation therapy	If extranodal NK-T-cell lymphoma is confined to the nose or nasal passages, external beam radiation therapy is used
Chemotherapy	Chemotherapy is often added to radiation therapy to treat extranodal NK/T-cell lymphoma If extranodal NK-T-cell lymphoma is more widespread, then chemotherapy may be more intense and higher doses may be used Drug regimen: (CHOP) Cyclophosphamide AND Doxorubicin AND Vincristine AND Prednisone CNS Prophylaxis: Methotrexate
Stem cell transplant	May be offered to some people with extranodal NK-T-cell lymphoma who relapse after initial treatment

References

↑ ^1.0 ^1.1 Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 02, 2016
↑ Dreyling, M.; Thieblemont, C.; Gallamini, A.; Arcaini, L.; Campo, E.; Hermine, O.; Kluin-Nelemans, J. C.; Ladetto, M.; Le Gouill, S.; Iannitto, E.; Pileri, S.; Rodriguez, J.; Schmitz, N.; Wotherspoon, A.; Zinzani, P.; Zucca, E. (2013). "ESMO Consensus conferences: guidelines on malignant lymphoma. part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma". Annals of Oncology. 24 (4): 857–877. doi:10.1093/annonc/mds643. ISSN 1569-8041.
↑ Isobe, Koichi; Uno, Takashi; Tamaru, Jun-ichi; Kawakami, Hiroyuki; Ueno, Naoyuki; Wakita, Hisashi; Okada, Jun-ichi; Itami, Jun; Ito, Hisao (2006). "Extranodal natural killer/T-cell lymphoma, nasal type". Cancer. 106 (3): 609–615. doi:10.1002/cncr.21656. ISSN 0008-543X.
↑ Li, Ye-Xiong; Yao, Bo; Jin, Jing; Wang, Wei-Hu; Liu, Yue-Ping; Song, Yong-Wen; Wang, Shu-Lian; Liu, Xin-Fan; Zhou, Li-Qiang; He, Xiao-Hui; Lu, Ning; Yu, Zi-Hao (2006). "Radiotherapy As Primary Treatment for Stage IE and IIE Nasal Natural Killer/T-Cell Lymphoma". Journal of Clinical Oncology. 24 (1): 181–189. doi:10.1200/JCO.2005.03.2573. ISSN 0732-183X.
↑ Kim, Seok Jin; Yang, Deok-Hwan; Kim, Jin Seok; Kwak, Jae-Yong; Eom, Hyeon-Seok; Hong, Dae Sik; Won, Jong Ho; Lee, Jae Hoon; Yoon, Dok Hyun; Cho, Jaeho; Nam, Taek-Keun; Lee, Sang-wook; Ahn, Yong Chan; Suh, Cheolwon; Kim, Won Seog (2014). "Concurrent chemoradiotherapy followed by l-asparaginase-containing chemotherapy, VIDL, for localized nasal extranodal NK/T cell lymphoma: CISL08-01 phase II study". Annals of Hematology. 93 (11): 1895–1901. doi:10.1007/s00277-014-2137-6. ISSN 0939-5555.

Template:WikiDoc Sources

[canadiancancer-1] 1.0 ^1.1 Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 02, 2016

[DreylingThieblemont2013-2] Dreyling, M.; Thieblemont, C.; Gallamini, A.; Arcaini, L.; Campo, E.; Hermine, O.; Kluin-Nelemans, J. C.; Ladetto, M.; Le Gouill, S.; Iannitto, E.; Pileri, S.; Rodriguez, J.; Schmitz, N.; Wotherspoon, A.; Zinzani, P.; Zucca, E. (2013). "ESMO Consensus conferences: guidelines on malignant lymphoma. part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma". Annals of Oncology. 24 (4): 857–877. doi:10.1093/annonc/mds643. ISSN 1569-8041.

[IsobeUno2006-3] Isobe, Koichi; Uno, Takashi; Tamaru, Jun-ichi; Kawakami, Hiroyuki; Ueno, Naoyuki; Wakita, Hisashi; Okada, Jun-ichi; Itami, Jun; Ito, Hisao (2006). "Extranodal natural killer/T-cell lymphoma, nasal type". Cancer. 106 (3): 609–615. doi:10.1002/cncr.21656. ISSN 0008-543X.

[LiYao2006-4] Li, Ye-Xiong; Yao, Bo; Jin, Jing; Wang, Wei-Hu; Liu, Yue-Ping; Song, Yong-Wen; Wang, Shu-Lian; Liu, Xin-Fan; Zhou, Li-Qiang; He, Xiao-Hui; Lu, Ning; Yu, Zi-Hao (2006). "Radiotherapy As Primary Treatment for Stage IE and IIE Nasal Natural Killer/T-Cell Lymphoma". Journal of Clinical Oncology. 24 (1): 181–189. doi:10.1200/JCO.2005.03.2573. ISSN 0732-183X.

[KimYang2014-5] Kim, Seok Jin; Yang, Deok-Hwan; Kim, Jin Seok; Kwak, Jae-Yong; Eom, Hyeon-Seok; Hong, Dae Sik; Won, Jong Ho; Lee, Jae Hoon; Yoon, Dok Hyun; Cho, Jaeho; Nam, Taek-Keun; Lee, Sang-wook; Ahn, Yong Chan; Suh, Cheolwon; Kim, Won Seog (2014). "Concurrent chemoradiotherapy followed by l-asparaginase-containing chemotherapy, VIDL, for localized nasal extranodal NK/T cell lymphoma: CISL08-01 phase II study". Annals of Hematology. 93 (11): 1895–1901. doi:10.1007/s00277-014-2137-6. ISSN 0939-5555.

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[2]

[3]

[4]

[5]

@@ Line 9: / Line 9: @@
 * Therapy of extranodal NK/T cell lymphoma depends on staging of the tumor:<ref name="DreylingThieblemont2013">{{cite journal|last1=Dreyling|first1=M.|last2=Thieblemont|first2=C.|last3=Gallamini|first3=A.|last4=Arcaini|first4=L.|last5=Campo|first5=E.|last6=Hermine|first6=O.|last7=Kluin-Nelemans|first7=J. C.|last8=Ladetto|first8=M.|last9=Le Gouill|first9=S.|last10=Iannitto|first10=E.|last11=Pileri|first11=S.|last12=Rodriguez|first12=J.|last13=Schmitz|first13=N.|last14=Wotherspoon|first14=A.|last15=Zinzani|first15=P.|last16=Zucca|first16=E.|title=ESMO Consensus conferences: guidelines on malignant lymphoma. part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma|journal=Annals of Oncology|volume=24|issue=4|year=2013|pages=857–877|issn=1569-8041|doi=10.1093/annonc/mds643}}</ref><ref name="IsobeUno2006">{{cite journal|last1=Isobe|first1=Koichi|last2=Uno|first2=Takashi|last3=Tamaru|first3=Jun-ichi|last4=Kawakami|first4=Hiroyuki|last5=Ueno|first5=Naoyuki|last6=Wakita|first6=Hisashi|last7=Okada|first7=Jun-ichi|last8=Itami|first8=Jun|last9=Ito|first9=Hisao|title=Extranodal natural killer/T-cell lymphoma, nasal type|journal=Cancer|volume=106|issue=3|year=2006|pages=609–615|issn=0008-543X|doi=10.1002/cncr.21656}}</ref><ref name="LiYao2006">{{cite journal|last1=Li|first1=Ye-Xiong|last2=Yao|first2=Bo|last3=Jin|first3=Jing|last4=Wang|first4=Wei-Hu|last5=Liu|first5=Yue-Ping|last6=Song|first6=Yong-Wen|last7=Wang|first7=Shu-Lian|last8=Liu|first8=Xin-Fan|last9=Zhou|first9=Li-Qiang|last10=He|first10=Xiao-Hui|last11=Lu|first11=Ning|last12=Yu|first12=Zi-Hao|title=Radiotherapy As Primary Treatment for Stage IE and IIE Nasal Natural Killer/T-Cell Lymphoma|journal=Journal of Clinical Oncology|volume=24|issue=1|year=2006|pages=181–189|issn=0732-183X|doi=10.1200/JCO.2005.03.2573}}</ref><ref name="KimYang2014">{{cite journal|last1=Kim|first1=Seok Jin|last2=Yang|first2=Deok-Hwan|last3=Kim|first3=Jin Seok|last4=Kwak|first4=Jae-Yong|last5=Eom|first5=Hyeon-Seok|last6=Hong|first6=Dae Sik|last7=Won|first7=Jong Ho|last8=Lee|first8=Jae Hoon|last9=Yoon|first9=Dok Hyun|last10=Cho|first10=Jaeho|last11=Nam|first11=Taek-Keun|last12=Lee|first12=Sang-wook|last13=Ahn|first13=Yong Chan|last14=Suh|first14=Cheolwon|last15=Kim|first15=Won Seog|title=Concurrent chemoradiotherapy followed by l-asparaginase-containing chemotherapy, VIDL, for localized nasal extranodal NK/T cell lymphoma: CISL08-01 phase II study|journal=Annals of Hematology|volume=93|issue=11|year=2014|pages=1895–1901|issn=0939-5555|doi=10.1007/s00277-014-2137-6}}</ref>
-{| class="wikitable"
+{|  style="border: 0px; font-size: 90%; margin: 3px;" align="center"
 |+'''Favored treatment of extranodal NK/T cell lymphoma''' based on staging
-!Stage
+! style="background: #4479BA; color:#FFF;" | Stage
-!Involvment
+! style="background: #4479BA; color:#FFF;" | Involvement
-!Common involvement place
+! style="background: #4479BA; color:#FFF;" | Common involvement place
-!Preferred therapy method
+! style="background: #4479BA; color:#FFF;" | Preferred therapy method
-!Radiation dosage
+! style="background: #4479BA; color:#FFF;" | Radiation dosage
-!Chemotherapy regimen
+! style="background: #4479BA; color:#FFF;" | Chemotherapy regimen
-!Alternative
+! style="background: #4479BA; color:#FFF;" | Alternative therapy
-!Over 69 /severe organ damage/low lymphocyte
+! style="background: #4479BA; color:#FFF;" | Over 69 /severe organ damage/low lymphocyte
 |-
-|I(E)
+| style="padding: 5px 5px; background: #DCDCDC;" |I(E)
-|Single extranodal involvement
+| style="padding: 5px 5px; background: #F5F5F5;" |Single extranodal involvement
-|upper aerodigestive tract
+| style="padding: 5px 5px; background: #F5F5F5;" |upper aerodigestive tract
-|Combined modality therapy‡
+| style="padding: 5px 5px; background: #F5F5F5;" |Combined modality therapy‡
-|50 Gy RT
+| style="padding: 5px 5px; background: #F5F5F5;" |50 Gy RT
-|DeVIC∞
+| style="padding: 5px 5px; background: #F5F5F5;" |DeVIC∞
-|40 Gy RT + weekly Cisplatin
+| style="padding: 5px 5px; background: #F5F5F5;" |40 Gy RT + weekly Cisplatin
-| -
+| style="padding: 5px 5px; background: #F5F5F5;" | -
 |-
-|II(E)
+| style="padding: 5px 5px; background: #DCDCDC;" |II(E)
-|Stage I(E) +One or more of  † involvments
+| style="padding: 5px 5px; background: #F5F5F5;" |Stage I(E) +One or more of  † involvements
-|upper aerodigestive tract
+| style="padding: 5px 5px; background: #F5F5F5;" |upper aerodigestive tract
-|Combined modality therapy
+| style="padding: 5px 5px; background: #F5F5F5;" |Combined modality therapy
-|50 Gy RT
+| style="padding: 5px 5px; background: #F5F5F5;" |50 Gy RT
-|DeVIC
+| style="padding: 5px 5px; background: #F5F5F5;" |DeVIC
-|40 Gy RT + weekly Cisplatin
+| style="padding: 5px 5px; background: #F5F5F5;" |40 Gy RT + weekly Cisplatin
-| -
+| style="padding: 5px 5px; background: #F5F5F5;" | -
 |-
-|III(E)•
+| style="padding: 5px 5px; background: #DCDCDC;" |III(E)•
-|Stage I (E) + Cervical lymph node involvment + infradiaphragmatic lymph node / Involvment of spleen
+| style="padding: 5px 5px; background: #F5F5F5;" |Stage I (E) + Cervical lymph node involvement + infra diaphragmatic lymph node / Involvement of spleen
-|Systemic /
+| style="padding: 5px 5px; background: #F5F5F5;" |Systemic /
 Disseminated
-|SMILE៛
+| style="padding: 5px 5px; background: #F5F5F5;" |SMILE៛
-|<nowiki>-</nowiki>
+| style="padding: 5px 5px; background: #F5F5F5;" |<nowiki>-</nowiki>
-|<nowiki>-</nowiki>
+| style="padding: 5px 5px; background: #F5F5F5;" |<nowiki>-</nowiki>
 |
-|Less intensive L-asparaginase-containing chemotherapy
+| style="padding: 5px 5px; background: #F5F5F5;" |Less intensive L-asparaginase-containing chemotherapy
 |-
-|IV
+| style="padding: 5px 5px; background: #DCDCDC;" |IV
-|Stage I(E) +isolated distant involvment
+| style="padding: 5px 5px; background: #F5F5F5;" |Stage I(E) +isolated distant involvement
-|Systemic /
+| style="padding: 5px 5px; background: #F5F5F5;" |Systemic /
 Disseminated
-|SMILE
+| style="padding: 5px 5px; background: #F5F5F5;" |SMILE
-|<nowiki>-</nowiki>
+| style="padding: 5px 5px; background: #F5F5F5;" |<nowiki>-</nowiki>
-|<nowiki>-</nowiki>
+| style="padding: 5px 5px; background: #F5F5F5;" |<nowiki>-</nowiki>
 |
-|Less intensive L-asparaginase-containing chemotherapy
+| style="padding: 5px 5px; background: #F5F5F5;" |Less intensive L-asparaginase-containing chemotherapy
 |}
-†: Cervical lymph node involvement / Involvment of other superdiaphragmatic lymph node regions / Isolated involvment of additional sites in the head and neck
+†: Cervical lymph node involvement / Involvement of other supradiaphragmatic lymph node regions / Isolated involvement of additional sites in the head and neck
 •: Rare
@@ Line 64: / Line 64: @@
 ‡: Combined modality therapy is radiation therapy with concurrent chemotherapy
-∞:Dexamethasone, Etoposide, Ifosfamide, Carboplatin.
+∞: Dexamethasone, Etoposide, Ifosfamide, Carboplatin.
 ៛: Dexamethasone. Methotrexate, Ifosfamide, L-asparaginase, Etoposide

Extranodal NK-T-cell lymphoma medical therapy: Difference between revisions

Revision as of 14:23, 30 August 2019

Overview

Medical Therapy

References

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