Schwannoma pathophysiology: Difference between revisions
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==Gross and Microscopic Pathology== | ==Gross and Microscopic Pathology== | ||
==== Microscopic appearance ==== | |||
*Conventional schwannomas are composed of spindle cells which demonstrate two growth patterns: Antoni type A and Antoni type B 7,8. | |||
*Antoni type A pattern: elongated cells are densely packed and arranged in fascicles. Palisades are sometimes seen; when prominent these form Verocay bodies. | |||
*Antoni type B pattern cells are less compact and are prone to cystic degeneration. | |||
===== Variants ===== | |||
Schwannoma variants include 6,8: | |||
* ancient schwannoma | |||
* cellular schwannoma | |||
** predominantly composed of Antoni A tissue | |||
** no Verocay bodies | |||
** most commonly found in a paravertebral location, or trigeminal nerves (CN V) | |||
* melanotic schwannoma: dense melanin pigment | |||
* plexiform schwannoma | |||
** usually arise from skin or subcutaneous tissues | |||
** usually diagnosed at birth or childhood | |||
** usually sporadic, but rarely associated with NF2 | |||
** should not be confused with plexiform neurofibromas | |||
*** associated with NF1 | |||
*** may undergo malignant change | |||
==Immunohistochemistry== | ==Immunohistochemistry== | ||
Revision as of 15:55, 15 October 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Maneesha Nandimandalam, M.B.B.S.[2]
Overview
Pathophysiology
Pathogenesis
Genetics
Associated Conditions
Gross and Microscopic Pathology
Microscopic appearance
- Conventional schwannomas are composed of spindle cells which demonstrate two growth patterns: Antoni type A and Antoni type B 7,8.
- Antoni type A pattern: elongated cells are densely packed and arranged in fascicles. Palisades are sometimes seen; when prominent these form Verocay bodies.
- Antoni type B pattern cells are less compact and are prone to cystic degeneration.
Variants
Schwannoma variants include 6,8:
- ancient schwannoma
- cellular schwannoma
- predominantly composed of Antoni A tissue
- no Verocay bodies
- most commonly found in a paravertebral location, or trigeminal nerves (CN V)
- melanotic schwannoma: dense melanin pigment
- plexiform schwannoma
- usually arise from skin or subcutaneous tissues
- usually diagnosed at birth or childhood
- usually sporadic, but rarely associated with NF2
- should not be confused with plexiform neurofibromas
- associated with NF1
- may undergo malignant change