Schwannoma pathophysiology: Difference between revisions
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==== Microscopic appearance ==== | ==== Microscopic appearance ==== | ||
*Conventional schwannomas are composed of spindle cells which demonstrate two growth patterns: Antoni type A and Antoni type B 7,8. | *Conventional schwannomas are composed of spindle cells which demonstrate two growth patterns: Antoni type A and Antoni type B 7,8.<ref name="pmid23413263">{{cite journal| author=Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M et al.| title=Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells. | journal=Brain | year= 2013 | volume= 136 | issue= Pt 2 | pages= 549-63 | pmid=23413263 | doi=10.1093/brain/aws353 | pmc=3572932 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23413263 }} </ref><ref name="pmid23031754">{{cite journal| author=Sayed SI, Rane P, Deshmukh A, Chaukar D, Menon S, Arya S et al.| title=Ancient schwannoma of the parapharynx causing dysphagia: a rare entity. | journal=Ann R Coll Surg Engl | year= 2012 | volume= 94 | issue= 7 | pages= e217-20 | pmid=23031754 | doi=10.1308/003588412X13373405385737 | pmc=3954264 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23031754 }} </ref><ref name="pmid24414536">{{cite journal| author=Giovannini M, Bonne NX, Vitte J, Chareyre F, Tanaka K, Adams R et al.| title=mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma. | journal=Neuro Oncol | year= 2014 | volume= 16 | issue= 4 | pages= 493-504 | pmid=24414536 | doi=10.1093/neuonc/not242 | pmc=3956353 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24414536 }} </ref> | ||
*Antoni type A pattern: elongated cells are densely packed and arranged in fascicles. Palisades are sometimes seen; when prominent these form Verocay bodies. | *Antoni type A pattern: elongated cells are densely packed and arranged in fascicles. Palisades are sometimes seen; when prominent these form Verocay bodies. | ||
*Antoni type B pattern cells are less compact and are prone to cystic degeneration. | *Antoni type B pattern cells are less compact and are prone to cystic degeneration. | ||
Revision as of 16:01, 15 October 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Maneesha Nandimandalam, M.B.B.S.[2]
Overview
Pathophysiology
Pathogenesis
Genetics
Associated Conditions
Gross and Microscopic Pathology
Microscopic appearance
- Conventional schwannomas are composed of spindle cells which demonstrate two growth patterns: Antoni type A and Antoni type B 7,8.[1][2][3]
- Antoni type A pattern: elongated cells are densely packed and arranged in fascicles. Palisades are sometimes seen; when prominent these form Verocay bodies.
- Antoni type B pattern cells are less compact and are prone to cystic degeneration.
Variants
Schwannoma variants include 6,8:
- ancient schwannoma
- cellular schwannoma
- predominantly composed of Antoni A tissue
- no Verocay bodies
- most commonly found in a paravertebral location, or trigeminal nerves (CN V)
- melanotic schwannoma: dense melanin pigment
- plexiform schwannoma
- usually arise from skin or subcutaneous tissues
- usually diagnosed at birth or childhood
- usually sporadic, but rarely associated with NF2
- should not be confused with plexiform neurofibromas
- associated with NF1
- may undergo malignant change
Immunohistochemistry
References
- ↑ Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M; et al. (2013). "Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells". Brain. 136 (Pt 2): 549–63. doi:10.1093/brain/aws353. PMC 3572932. PMID 23413263.
- ↑ Sayed SI, Rane P, Deshmukh A, Chaukar D, Menon S, Arya S; et al. (2012). "Ancient schwannoma of the parapharynx causing dysphagia: a rare entity". Ann R Coll Surg Engl. 94 (7): e217–20. doi:10.1308/003588412X13373405385737. PMC 3954264. PMID 23031754.
- ↑ Giovannini M, Bonne NX, Vitte J, Chareyre F, Tanaka K, Adams R; et al. (2014). "mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma". Neuro Oncol. 16 (4): 493–504. doi:10.1093/neuonc/not242. PMC 3956353. PMID 24414536.