Cancer of unknown primary origin historical perspective: Difference between revisions
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==Overview== | ==Overview== | ||
Cancer of unknown primary origin was first discovered in the 1980s and was based solely on imaging studies. | Cancer of unknown primary origin was first discovered in the 1980s and was based solely on [[imaging studies]]. | ||
==Historical Perspective== | ==Historical Perspective== | ||
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===Discovery=== | ===Discovery=== | ||
*Cancer of unknown primary origin was discovered in the 1980s. | *Cancer of unknown primary origin was discovered in the 1980s. | ||
*In the beginning, cancer of unknown primary was defined based on imaging results and only few empirical therapy options were available.<ref name="pmid25140961">{{cite journal| author=Varadhachary GR, Raber MN| title=Cancer of unknown primary site. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 8 | pages= 757-65 | pmid=25140961 | doi=10.1056/NEJMra1303917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25140961 }} </ref> | *In the beginning, cancer of unknown primary was defined based on imaging results and only few [[Empiric therapy|empirical therapy]] options were available.<ref name="pmid25140961">{{cite journal| author=Varadhachary GR, Raber MN| title=Cancer of unknown primary site. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 8 | pages= 757-65 | pmid=25140961 | doi=10.1056/NEJMra1303917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25140961 }} </ref> | ||
=== Landmark Events in the Development of Treatment Strategies === | === Landmark Events in the Development of Treatment Strategies === | ||
* Between 1980 and 1990, the definition of cancer of unknown primary origin was based solely on imaging and treatment was limited to few empirical therapies. | * Between 1980 and 1990, the definition of cancer of unknown primary origin was based solely on imaging and [[Therapy|treatment]] was limited to few [[Empiric therapy|empirical therapies]]. | ||
* From 1990 to 2000, improvement in imaging techniques and immunohistochemical testing aided in the diagnosis of CUP. This time range also saw the rise of empirical therapy in treating CUP. | * From 1990 to 2000, improvement in [[imaging]] techniques and [[Immunohistochemical|immunohistochemical testing]] aided in the [[diagnosis]] of CUP. This time range also saw the rise of empirical therapy in treating CUP. | ||
* In 2000, the emergence of tissue-of-origin molecular profiling, provided a more successful site-directed therapy especially when used with | * In 2000, the emergence of tissue-of-origin molecular profiling, provided a more successful site-directed therapy especially when used with [[Immunohistochemical|immunohistochemical testing]] | ||
**Hence, the years 2000-2010 realized an increase in tailored [[therapy]] models.<ref name="pmid20427384">{{cite journal| author=Greco FA, Spigel DR, Yardley DA, Erlander MG, Ma XJ, Hainsworth JD| title=Molecular profiling in unknown primary cancer: accuracy of tissue of origin prediction. | journal=Oncologist | year= 2010 | volume= 15 | issue= 5 | pages= 500-6 | pmid=20427384 | doi=10.1634/theoncologist.2009-0328 | pmc=3227979 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20427384 }}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 15:17, 16 October 2019
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Cancer of unknown primary origin Microchapters |
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Differentiating Cancer of Unknown Primary Origin from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Roukoz A. Karam, M.D.[2]
Overview
Cancer of unknown primary origin was first discovered in the 1980s and was based solely on imaging studies.
Historical Perspective
Discovery
- Cancer of unknown primary origin was discovered in the 1980s.
- In the beginning, cancer of unknown primary was defined based on imaging results and only few empirical therapy options were available.[1]
Landmark Events in the Development of Treatment Strategies
- Between 1980 and 1990, the definition of cancer of unknown primary origin was based solely on imaging and treatment was limited to few empirical therapies.
- From 1990 to 2000, improvement in imaging techniques and immunohistochemical testing aided in the diagnosis of CUP. This time range also saw the rise of empirical therapy in treating CUP.
- In 2000, the emergence of tissue-of-origin molecular profiling, provided a more successful site-directed therapy especially when used with immunohistochemical testing
References
- ↑ Varadhachary GR, Raber MN (2014). "Cancer of unknown primary site". N Engl J Med. 371 (8): 757–65. doi:10.1056/NEJMra1303917. PMID 25140961.
- ↑ Greco FA, Spigel DR, Yardley DA, Erlander MG, Ma XJ, Hainsworth JD (2010). "Molecular profiling in unknown primary cancer: accuracy of tissue of origin prediction". Oncologist. 15 (5): 500–6. doi:10.1634/theoncologist.2009-0328. PMC 3227979. PMID 20427384.