Primary cutaneous follicle centre lymphoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Soroush Seifirad, M.D.[3]

Overview

The incidence of primary cutaneous follicle centre lymphoma increases with age; the median age at diagnosis is 51 years. Males are more commonly affected with primary cutaneous follicle centre lymphoma than females.

Epidemiology and Demographics

According to a large population-based study focused on cutaneous lymphomas (CL) in the United States by Bradford et al. on 3884 Cutaneous lymphomas 9CLs) diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjusted incidence rate [IR] = 7.7/1 000 000 person-years), whereas cutaneous B-cell lymphomas(CBCLs) accounted for 29% (IR = 3.1/1 000 000 person-years). Primary cutaneous follicle center lymphoma is the mostcommon primary cutaneous B-cell lymphoma.4,10 It accounts for approximately 10% to 20% of all cutaneous lymphomas and comprises about 50% of primary cutaneous B-cell lymphomas.2–4,10–12 Most commonly, patients are white men, 50 to 60 years old, although younger patients and women may also develop this lymphoma.2,4,10,11,13–18 Patients with PCFCL typically present with one or more localized, erythematous papules, plaques, and/or tumors on the scalp/forehead or trunk (Figure 1, A and B).2–4,10–16,19 Approximately 60% of patients will have more than one lesion; most commonly multiple lesions occur in a localized area (30%–40%), although a few patients have multiple dispersed skin lesions (10%–20%).2

Incidence

• Over the past 25 years, the CL incidence rate increased from 5.0/1 000 000 person-years during 1980-1982 to 14.3 during 2001-2003.
• During 2004-2005, the CL IR was 12.7. This recent apparent change could be incomplete case ascertainment or potential levelling off of incidence rates.
• CLs rates vary markedly by race and sex, supporting the notion that they represent distinct disease entities.

Prevalence

• There is no prevalence report primary cutaneous follicle centre lymphoma

Case-fatality rate/Mortality rate

• In [year], the incidence of primary cutaneous follicle centre lymphoma is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
• The case-fatality rate/mortality rate of primary cutaneous follicle centre lymphoma is approximately [number range].

Age

The incidence of primary cutaneous follicle centre lymphoma increases with age; the median age at diagnosis is 51 years.

Race

• Primary cutaneous follicle centre lymphoma usually affects individuals of the blacks and non-Hispanic whites followed by Hispanic whites and Asian/Pacific Islanders . Whites of European descent individuals are less likely to develop primary cutaneous follicle centre lymphoma.
• According to Bradford et al. CL incidence rate were highest among blacks and non-Hispanic whites (both 11.5/1 000 000 person-years), followed by Hispanic whites (7.9) and Asian/Pacific Islanders (7.1). The CTCL IR was highest among blacks (10.0/1 000 000 person-years), whereas the CBCL IR was highest among non-Hispanic whites (3.5).

Gender

Males are more commonly affected with primary cutaneous follicle centre lymphoma than females.

According to Bradford et al. also, males had a statistically significant higher incidence of CL than females (14.0 vs 8.2/1 000 000 person-years, respectively; male-female IR ratio [M/F IRR] = 1.72; P < .001).

Region

• The majority of primary cutaneous follicle centre lymphoma cases are reported in [geographical region].

• primary cutaneous follicle centre lymphoma is a common/rare disease that tends to affect [patient population 1] and [patient population 2].