Cardiac amyloidosis history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
Cardiac amyloid cab be associated with the following symptoms:<ref name="pmid9578896">{{cite journal |author=Dubrey SW, Cha K, Anderson J, ''et al.'' |title=The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement |journal=[[QJM : Monthly Journal of the Association of Physicians]] |volume=91 |issue=2 |pages=141–57 |year=1998 |month=February |pmid=9578896 |doi= |url=}}</ref> | Cardiac amyloid cab be associated with the following symptoms:<ref name="pmid9578896">{{cite journal |author=Dubrey SW, Cha K, Anderson J, ''et al.'' |title=The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement |journal=[[QJM : Monthly Journal of the Association of Physicians]] |volume=91 |issue=2 |pages=141–57 |year=1998 |month=February |pmid=9578896 |doi= |url=}}</ref> | ||
*[[Congestive heart failure]] such as | *[[Congestive heart failure]] with associated symptoms such as | ||
**[[Fatigue]] | **[[Fatigue]] | ||
** [[Dyspnea]] | ** [[Dyspnea]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]; Cafer Zorkun, M.D., Ph.D. [4]; Lakshmi Gopalakrishnan, M.B.B.S. [5]
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Overview
Amyloidosis is a multi-system disease involving many organs simultaneously. Approximately more than 50% of the patients with amyloidosis present with right heart failure symptoms. The most common symptoms observed in patients with cardiac amyloidosis include fatigue, weight loss, and periorbital purpura.[1]
Symptoms
Cardiac amyloid cab be associated with the following symptoms:[2]
- Congestive heart failure with associated symptoms such as
- Fatigue
- Dyspnea
- Dizziness
- Orthopnea[1]
- Peripheral edema
- Weight loss due to cardiac cachexia
- Ascites
- Arrhythmias such as palpitations
- Syncope and presyncope: Syncope on exertion is an ominous sign of cardiac amyloidosis, as these patients cannot augment their cardiac output due to stiff walls.[3]
- Postural hypotension may be observed in patients with subendothelial amyloid deposition.[4]
- Chest pain or chest discomfort [5][6]
- Non-specific symptoms like:
References
- ↑ 1.0 1.1 Kyle RA, Gertz MA (1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Seminars in Hematology. 32 (1): 45–59. PMID 7878478. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Dubrey SW, Cha K, Anderson J; et al. (1998). "The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement". QJM : Monthly Journal of the Association of Physicians. 91 (2): 141–57. PMID 9578896. Unknown parameter
|month=ignored (help) - ↑ Mugnai G, Cicoira M, Rossi A, Vassanelli C (2011). "Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report". Experimental and Clinical Cardiology. 16 (2): 51–3. PMC 3126684. PMID 21747665.
- ↑ Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A (2006). "Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (3): 143–53. doi:10.1080/13506120600877136. PMID 17062380. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Mueller PS, Edwards WD, Gertz MA (2000). "Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis". The American Journal of Medicine. 109 (3): 181–8. PMID 10974179. Unknown parameter
|month=ignored (help) - ↑ Al Suwaidi J, Velianou JL, Gertz MA; et al. (1999). "Systemic amyloidosis presenting with angina pectoris". Annals of Internal Medicine. 131 (11): 838–41. PMID 10610629. Unknown parameter
|month=ignored (help)