Teratoma pathophysiology: Difference between revisions
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==Associated conditions== | ==Associated conditions== | ||
Conditions associated with teratoma included: | Conditions associated with teratoma included: | ||
*Anti-NMDA receptor encephalitis<ref name="pmid29245365">Liang Z, Yang S, Sun X, Li B, Li W, Liu Z et al. (2017) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=29245365 Teratoma-associated anti-NMDAR encephalitis: Two cases report and literature review.] ''Medicine (Baltimore)'' 96 (49):e9177. [http://dx.doi.org/10.1097/MD.0000000000009177 DOI:10.1097/MD.0000000000009177] PMID: [https://pubmed.gov/29245365 29245365]</ref><ref name="DalmauGleichman2008">{{cite journal|last1=Dalmau|first1=Josep|last2=Gleichman|first2=Amy J|last3=Hughes|first3=Ethan G|last4=Rossi|first4=Jeffrey E|last5=Peng|first5=Xiaoyu|last6=Lai|first6=Meizan|last7=Dessain|first7=Scott K|last8=Rosenfeld|first8=Myrna R|last9=Balice-Gordon|first9=Rita|last10=Lynch|first10=David R|title=Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies|journal=The Lancet Neurology|volume=7|issue=12|year=2008|pages=1091–1098|issn=14744422|doi=10.1016/S1474-4422(08)70224-2}}</ref> | *Anti-NMDA receptor encephalitis<ref name="pmid29245365">Liang Z, Yang S, Sun X, Li B, Li W, Liu Z et al. (2017) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=29245365 Teratoma-associated anti-NMDAR encephalitis: Two cases report and literature review.] ''Medicine (Baltimore)'' 96 (49):e9177. [http://dx.doi.org/10.1097/MD.0000000000009177 DOI:10.1097/MD.0000000000009177] PMID: [https://pubmed.gov/29245365 29245365]</ref><ref name="DalmauGleichman2008">{{cite journal|last1=Dalmau|first1=Josep|last2=Gleichman|first2=Amy J|last3=Hughes|first3=Ethan G|last4=Rossi|first4=Jeffrey E|last5=Peng|first5=Xiaoyu|last6=Lai|first6=Meizan|last7=Dessain|first7=Scott K|last8=Rosenfeld|first8=Myrna R|last9=Balice-Gordon|first9=Rita|last10=Lynch|first10=David R|title=Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies|journal=The Lancet Neurology|volume=7|issue=12|year=2008|pages=1091–1098|issn=14744422|doi=10.1016/S1474-4422(08)70224-2}}</ref><ref name="MalayevAlberts2015">{{cite journal|last1=Malayev|first1=Yuliya|last2=Alberts|first2=Jared|last3=Verardi|first3=Mary Ann|last4=Mattison|first4=Anissa R.|last5=Imlay|first5=Sherwin|title=Immature Teratoma Associated With Anti–N-Methyl-D-Aspartate Receptor Encephalitis|journal=The Journal of the American Osteopathic Association|volume=115|issue=9|year=2015|pages=573|issn=0098-6151|doi=10.7556/jaoa.2015.116}}</ref> | ||
Revision as of 18:43, 1 November 2019
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Teratoma Microchapters |
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Teratoma pathophysiology On the Web |
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Risk calculators and risk factors for Teratoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]
Overview
The histopathology of teratoma depends on the histological subtype.Teratoma is a germ cell tumor due to abnormal development of pluripotent cells.
Pathophysiology
| Germ cell | |||||||||||||||||||||||||||||||||||||||
| Pathogenesis | Malignant transformation | ||||||||||||||||||||||||||||||||||||||
| Mature teratoma | |||||||||||||||||||||||||||||||||||||||
| {{{ }}} | Tumors with primitive embryonic ectoderm, mesoderm, and/or endoderm differentiation | {{{ }}} | |||||||||||||||||||||||||||||||||||||
| {{{ }}} | |||||||||||||||||||||||||||||||||||||||
| Immature teratoma | |||||||||||||||||||||||||||||||||||||||
Pathogenesis
- Mature teratoma arises from a pathological transformation of primordial germ cell during the develompment.[1][2]
- Mature teratoma comes from a single germ cell tumor after first phase of meiosis and failure of meiosis type II.[3][4]
- Mature teratoma contains a well differentiated tumor with all three germ layers (ectoderm, mesoderm and endoderm).[2]
- Mature teratoma may be located in the embryonic fusion midline or paraxial, mediastinum, ovary, retroperitoneum, and sacrococcygeal.[5]
- Immature teratoma may be due to the malignant tranformation of primitive germ cell layers
Genetics
Genes involved in the pathogenesis of teratoma include:[6]
- Gain of part or all chromosomes
- 1p
- 16p
- 19
- 22q
Associated conditions
Conditions associated with teratoma included:
References
- ↑ Vural, F.; Vural, B.; Paksoy, N. (2015). "Vaginal teratoma: A case report and review of the literature". Journal of Obstetrics and Gynaecology. 35 (7): 757–758. doi:10.3109/01443615.2015.1004525. ISSN 0144-3615.
- ↑ 2.0 2.1 El-Maarri, Osman; Rijlaarsdam, Martin A.; Tax, David M. J.; Gillis, Ad J. M.; Dorssers, Lambert C. J.; Koestler, Devin C.; de Ridder, Jeroen; Looijenga, Leendert H. J. (2015). "Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors". PLOS ONE. 10 (4): e0122146. doi:10.1371/journal.pone.0122146. ISSN 1932-6203.
- ↑ Linder, David; McCaw, Barbara Kaiser; Hecht, Frederick (1975). "Parthenogenic Origin of Benign Ovarian Teratomas". New England Journal of Medicine. 292 (2): 63–66. doi:10.1056/NEJM197501092920202. ISSN 0028-4793.
- ↑ Surti U, Hoffner L, Chakravarti A, Ferrell RE (1990). "Genetics and biology of human ovarian teratomas. I. Cytogenetic analysis and mechanism of origin". Am J Hum Genet. 47 (4): 635–43. PMC 1683780. PMID 2220805.
- ↑ Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994). "Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature". Obstet Gynecol. 84 (1): 22–8. PMID 8008317.
- ↑ Kraggerud SM, Szymanska J, Abeler VM, Kaern J, Eknaes M, Heim S et al. (2000) DNA copy number changes in malignant ovarian germ cell tumors. Cancer Res 60 (11):3025-30. PMID: 10850452
- ↑ Liang Z, Yang S, Sun X, Li B, Li W, Liu Z et al. (2017) Teratoma-associated anti-NMDAR encephalitis: Two cases report and literature review. Medicine (Baltimore) 96 (49):e9177. DOI:10.1097/MD.0000000000009177 PMID: 29245365
- ↑ Dalmau, Josep; Gleichman, Amy J; Hughes, Ethan G; Rossi, Jeffrey E; Peng, Xiaoyu; Lai, Meizan; Dessain, Scott K; Rosenfeld, Myrna R; Balice-Gordon, Rita; Lynch, David R (2008). "Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies". The Lancet Neurology. 7 (12): 1091–1098. doi:10.1016/S1474-4422(08)70224-2. ISSN 1474-4422.
- ↑ Malayev, Yuliya; Alberts, Jared; Verardi, Mary Ann; Mattison, Anissa R.; Imlay, Sherwin (2015). "Immature Teratoma Associated With Anti–N-Methyl-D-Aspartate Receptor Encephalitis". The Journal of the American Osteopathic Association. 115 (9): 573. doi:10.7556/jaoa.2015.116. ISSN 0098-6151.