Familial amyloidosis other imaging findings: Difference between revisions
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==Overview== | ==Overview== | ||
[[Scintigraphy|Total body SAP component scintigraphy]] may be used in the workup and follow-up of patients with [[amyloid]] deposition. This method has been observed to have high [[sensitivity]] (90%) and requires a low [[radioactive]] dose which makes it a safe and effective method. The radiolabeled SAP binds to aa [[amyloid]] and localizes its deposition semiquantitatively. | |||
==Other Imaging Findings== | ==Other Imaging Findings== | ||
===Total Body SAP Scintigraphy=== | |||
*[[Scintigraphy|Total body SAP component scintigraphy]] may be used in the workup and follow-up of patients with [[amyloid]] deposition.<ref name="Hawkins2002">{{cite journal|last1=Hawkins|first1=Philip N.|title=Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis|journal=Current Opinion in Nephrology and Hypertension|volume=11|issue=6|year=2002|pages=649–655|issn=1062-4821|doi=10.1097/00041552-200211000-00013}}</ref><ref name="Hazenbergvan Rijswijk2006">{{cite journal|last1=Hazenberg|first1=Bouke P.C.|last2=van Rijswijk|first2=Martin H.|last3=Piers|first3=D. Albertus|last4=Lub-de Hooge|first4=Marjolijn N.|last5=Vellenga|first5=Edo|last6=Haagsma|first6=Elizabeth B.|last7=Hawkins|first7=Philip N.|last8=Jager|first8=Pieter L.|title=Diagnostic Performance of 123I-Labeled Serum Amyloid P Component Scintigraphy in Patients with Amyloidosis|journal=The American Journal of Medicine|volume=119|issue=4|year=2006|pages=355.e15–355.e24|issn=00029343|doi=10.1016/j.amjmed.2005.08.043}}</ref> | |||
* This method has been observed to have high [[sensitivity]] (90%) and requires a low [[radioactive]] dose which makes its usage safe and effective. | |||
* The radio labeled SAP binds to aa [[amyloid]] and localizes its deposition semi quantitatively.<ref name="PapaLachmann2018">{{cite journal|last1=Papa|first1=Riccardo|last2=Lachmann|first2=Helen J.|title=Secondary, AA, Amyloidosis|journal=Rheumatic Disease Clinics of North America|volume=44|issue=4|year=2018|pages=585–603|issn=0889857X|doi=10.1016/j.rdc.2018.06.004}}</ref> | |||
* However, this imaging modality is unable to identify deposits in hollow, diffuse, or small structures, such as the [[gastrointestinal tract]], [[skin]], and [[nerves]]. | |||
*[ | * Also, SAP [[scintigraphy]] is unable to detect cardiac and lung involvement due to movement and blood content of these organs. | ||
*[ | * Given the rarity of cardiac involvement in aa [[amyloidosis]], an staging systems using cardiac imaging or biomarkers is not validated for detection of aa [[amyloid]] deposition in heart. | ||
*[ | * Additionally, uremic cardiomyopathy is not distinguishable from [[amyloid]] deposition and [[cardiac magnetic resonance]] is relatively [[contraindicated]] in [[patients]] with secondary amyloidosis due to [[Renal failure|advanced renal disease]]. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 20:52, 4 November 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Total body SAP component scintigraphy may be used in the workup and follow-up of patients with amyloid deposition. This method has been observed to have high sensitivity (90%) and requires a low radioactive dose which makes it a safe and effective method. The radiolabeled SAP binds to aa amyloid and localizes its deposition semiquantitatively.
Other Imaging Findings
Total Body SAP Scintigraphy
- Total body SAP component scintigraphy may be used in the workup and follow-up of patients with amyloid deposition.[1][2]
- This method has been observed to have high sensitivity (90%) and requires a low radioactive dose which makes its usage safe and effective.
- The radio labeled SAP binds to aa amyloid and localizes its deposition semi quantitatively.[3]
- However, this imaging modality is unable to identify deposits in hollow, diffuse, or small structures, such as the gastrointestinal tract, skin, and nerves.
- Also, SAP scintigraphy is unable to detect cardiac and lung involvement due to movement and blood content of these organs.
- Given the rarity of cardiac involvement in aa amyloidosis, an staging systems using cardiac imaging or biomarkers is not validated for detection of aa amyloid deposition in heart.
- Additionally, uremic cardiomyopathy is not distinguishable from amyloid deposition and cardiac magnetic resonance is relatively contraindicated in patients with secondary amyloidosis due to advanced renal disease.
References
- ↑ Hawkins, Philip N. (2002). "Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis". Current Opinion in Nephrology and Hypertension. 11 (6): 649–655. doi:10.1097/00041552-200211000-00013. ISSN 1062-4821.
- ↑ Hazenberg, Bouke P.C.; van Rijswijk, Martin H.; Piers, D. Albertus; Lub-de Hooge, Marjolijn N.; Vellenga, Edo; Haagsma, Elizabeth B.; Hawkins, Philip N.; Jager, Pieter L. (2006). "Diagnostic Performance of 123I-Labeled Serum Amyloid P Component Scintigraphy in Patients with Amyloidosis". The American Journal of Medicine. 119 (4): 355.e15–355.e24. doi:10.1016/j.amjmed.2005.08.043. ISSN 0002-9343.
- ↑ Papa, Riccardo; Lachmann, Helen J. (2018). "Secondary, AA, Amyloidosis". Rheumatic Disease Clinics of North America. 44 (4): 585–603. doi:10.1016/j.rdc.2018.06.004. ISSN 0889-857X.