Dilated cardiomyopathy differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]

Overview

Dilated cardiomyopathy should be differentiated from other causes of cardiac dysfunction

Differentiating Beriberi from other Diseases

Dilated cardiomyopathy should be differentiated from other causes of cardiac dysfunction

Disorders	Etiology	Clinical Presentation	Laboratory Findings
Acute Coronary Syndrome	Atherosclerosis Coronary thrombosis Plaque rupture	Chest Pain Dyspnea Palpitations Nausea, vomiting, and sweating	Echocardiogram: ST segment and T wave changes, pathological Q waves. Elevated blood troponin levels (after 6 hours of attack onset) Elevated blood CK-MB levels
Acute Pericarditis	Idiopathic Viral infection Connective tissue diseases (e.g. SLE) Dressler's Syndrome (after MI) Familial Mediterranean fever	Sharp chest pain (that increases with breathing/cough, reduced with leaning forward) Pericardial friction rub Fever (for inflammatory causes)	Echocardiogram: Slight ST segment elevation in several leads & diffuse T wave inversion CBC: Increased WBCs count Modest increase in CK-MB Elevated CRP levels.
Amphetamine/Cocaine Cardiomyopathy	Illicit drug use	History of drug use Chest pain Palpitation Other symptoms of amphetamine/cocaine intoxication	Drug and toxicology screen Elevated serum CK (rhabdomyolysis) Impaired electrolytes levels
Arrhythmogenic right ventricular cardiomyopathy (ARVC/D)	Idiopathic (but may be due to resolving myocarditis or genetic alterations in desmosomal proteins as plakoglobin and desmoplakin	Frequently symptomless until sudden cardiac death. Palpitations (Ventricular arrhythmia and conduction abnormalities) Exertional dyspnea Syncope	Diagnostic criteria are based on: Electrocardiogram Imaging modalities as 2D echocardiography and MRI.
Wet Beriberi	Inadequate thiamine intake (rice-based foods, alcoholism, and malnutrition) Increased thiamine loss (protracted vomiting) Inadequate absorption (after bariatric surgery or genetic mutation)
Cardiac Tamponade
Thyrotoxicosis
Hypertrophic Cardiomyopathy
Left ventricular noncompaction
Myocarditis
Restrictive Cardiomyopathy