Coronavirus Diagnostic Criteria: Difference between revisions
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=== MERS-CoV === | === MERS-CoV === | ||
Criteria for diagnosis of MERS-CoV RNA: a positive result for at least one of the following: | Criteria for diagnosis of MERS-CoV RNA: a positive result for at least one of the following: | ||
* Positivity for at least two MERS-CoV-specific gene targets (''upE'', ''ORF1a'', ''ORF1b'', ''N'') by real-time RT-PCR (recommended) | * Positivity for at least two MERS-CoV-specific gene targets (''upE'', ''ORF1a'', ''ORF1b'', ''N'') by real-time RT-PCR (recommended) | ||
* Positivity on RT-PCR result for at least one MERS-CoV-specific gene target [''ORF1b'' (''RdRp''), ''N''], AND confirmation by base sequence analysis of the PCR product | * Positivity on RT-PCR result for at least one MERS-CoV-specific gene target [''ORF1b'' (''RdRp''), ''N''], AND confirmation by base sequence analysis of the PCR product | ||
* Diagnosis by serological tests: a) Seroconversion using two serum specimens collected at an interval of at least 14 days b) The screening test with ELISA or IFA, and the confirmatory neutralization test <br /> | * Diagnosis by serological tests: a) Seroconversion using two serum specimens collected at an interval of at least 14 days b) The screening test with ELISA or IFA, and the confirmatory neutralization test | ||
=== SARS-CoV === | |||
<br /> | |||
{| class="wikitable" | |||
|+ | |||
!Cinical Criteria | |||
!Laboratory Criteria | |||
!Epidemiological Criteria | |||
|- | |||
|Fever > 38C and respiratory illness | |||
|Antibody to SARS-CoV ( > 28 days or acute) | |||
|Travel history (10 days) to SARS endemic area | |||
|- | |||
|Radiological findings | |||
|Detection of SARS-CoV RNA by RT-PCR and confirmation by PCR assay | |||
|Close contact with SARS infected patient | |||
|- | |||
|Autopsy findings | |||
|Isolation of virus | |||
| | |||
|} | |||
==References== | ==References== | ||
<references /> | |||
Revision as of 16:10, 3 February 2020
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Coronavirus Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Coronavirus Diagnostic Criteria On the Web |
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American Roentgen Ray Society Images of Coronavirus Diagnostic Criteria |
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Risk calculators and risk factors for Coronavirus Diagnostic Criteria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Criteria
2019-nCoV
Patients in the United States who meet the following criteria should be evaluated as in association with the outbreak of 2019-nCoV in Wuhan City, China.
| Clinical Features | & | Epidemiologic Risk |
|---|---|---|
| Fever and symptoms of lower respiratory illness (e.g., cough, difficulty breathing) | and | In the last 14 days before symptom onset, a history of travel from Wuhan City, China.
– or – In the last 14 days before symptom onset, close contact2 with a person who is under investigation for 2019-nCoV while that person was ill. |
| Fever or symptoms of lower respiratory illness (e.g., cough, difficulty breathing) | and | In the last 14 days, close contact2 with an ill laboratory-confirmed 2019-nCoV patient. |
MERS-CoV
Criteria for diagnosis of MERS-CoV RNA: a positive result for at least one of the following:
- Positivity for at least two MERS-CoV-specific gene targets (upE, ORF1a, ORF1b, N) by real-time RT-PCR (recommended)
- Positivity on RT-PCR result for at least one MERS-CoV-specific gene target [ORF1b (RdRp), N], AND confirmation by base sequence analysis of the PCR product
- Diagnosis by serological tests: a) Seroconversion using two serum specimens collected at an interval of at least 14 days b) The screening test with ELISA or IFA, and the confirmatory neutralization test
SARS-CoV
| Cinical Criteria | Laboratory Criteria | Epidemiological Criteria |
|---|---|---|
| Fever > 38C and respiratory illness | Antibody to SARS-CoV ( > 28 days or acute) | Travel history (10 days) to SARS endemic area |
| Radiological findings | Detection of SARS-CoV RNA by RT-PCR and confirmation by PCR assay | Close contact with SARS infected patient |
| Autopsy findings | Isolation of virus |