Andersen-Tawil syndrome electrocardiogram

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]; Raviteja Guddeti, M.B.B.S. [3]

Overview

An ECG may be very helpful in the diagnosis of Andersen-Tawil Syndrome. Findings on an ECG diagnostic of Andersen-Tawil Syndrome include a long QTc (LQT) interval, U waves, wide T-U junction and T-waves.

Electrocardiogram

An ECG may be helpful in the diagnosis of Andersen-Tawil Syndrome. Findings on an ECG diagnostic of Andersen-Tawil Syndrome include:

• A long QTc (LQT) interval
• T-U patterns which are very characteristic to the syndrome.
• Prominent U-wave enlargement which are biphasic in limb leads
• A wide T-U junction
• Prolonged terminal T-wave
• Premature ventricular contractions (PVC) especially at "rest" in Andersen - Tawil syndrome (ATS) patients
• Polymorphic ventricular tachycardia (PMVT) which is called bidirectional ventricular tachycardia (BiVT)

Electrocardiogram

Although polymorphic ventricular tachycardia is a common arrhythmia in patients with Anderson syndrome, decompensation into a hemodynamically compromising rhythm, or ventricular fibrillation, is rare. The following EKG findings are seen in patients with Andersen-Tawil syndrome:

• Biphasic U waves in limb leads
• Widened T-U junction
• Large U waves
• Prolonged terminal T wave downslope
• Prolonged Q-U intervals

References

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